Abstract: The present disclosure provides various medical devices, electronic devices, systems, and related methods. In various embodiments, an electronic device may be selectively coupled to, and removable from, a medical device. The coupling may include physical coupling, electrical coupling, or both. In one embodiment, an electronic device is configured for coupling with a hemostasis valve. The electronic device may provide power and/or data connections for an elongated flexible instrument passing through the hemostasis valve, for a sensor associated with the valve, or both. In another embodiment, the electronic device may be selectively and directly coupled with an elongated flexible instrument for power and/or communication with associated electrical components.