Abstract: Provided are chimeric antigen receptors (CARs) having antigen specificity for B-cell Maturation Antigen (BCMA). Also provided are related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CARs. Methods of treating or preventing cancer in a mammal are also provided.

Abstract: Systems and methods are provided for enhancing techniques for provisioning optical channels to allow optical networks to operate in an optimal fashion. A method, according to one implementation, includes receiving measured optical performance parameters of a plurality of optical channels transmitted over an optical spectrum between two network elements in an optical line system; determining a performance profile of the optical spectrum based on the measured optical performance parameters; translating the performance profile into configuration information for the two network elements; and causing provisioning of the two network elements based on the configuration information. The measured optical performance parameters are for one or more unassigned optical channels on the optical spectrum, with the measured optical performance parameters being made on one or more optical modems.

Abstract: Systems and methods are provided for enhancing techniques for provisioning optical channels to allow optical networks to operate in an optimal fashion. A method, according to one implementation, includes utilizing a plurality of modems to measure optical performance parameters of a plurality of optical channels of an optical spectrum. Each optical channel is previously unassigned in an unknown optical link system to be commissioned. The modems are arranged within a group for communicating optical signals within the optical spectrum across the unknown optical link system to an unknown far-end network element. The method also includes provisioning the plurality of optical channels based on the measured optical performance parameters to enable data communication between the near-end network element and the far-end network element. Before commissioning, the unknown optical link system does not allow data communication between the near-end network element and the far-end network element.

Abstract: Systems and methods are provided for enhancing techniques for provisioning optical channels to allow optical networks to operate in an optimal fashion. A method, according to one implementation, includes utilizing a plurality of modems to measure optical performance parameters of a plurality of optical channels of an optical spectrum. Each optical channel is previously unassigned in an unknown optical link system to be commissioned. The modems are arranged within a group for communicating optical signals within the optical spectrum across the unknown optical link system to an unknown far-end network element. The method also includes provisioning the plurality of optical channels based on the measured optical performance parameters to enable data communication between the near-end network element and the far-end network element. Before commissioning, the unknown optical link system does not allow data communication between the near-end network element and the far-end network element.

Abstract: The present invention provides a wearable device, a system for manufacturing a wearable device and a method of neural activity control. The device for temporal interference simulation includes a pair of electrodes at penalizable location. The electrodes each send out a high frequency electromagnetic fields with a very slight difference in the two frequencies. The fields superimpose at a specified region of the brain, which is customized depending on the location of neural activity control, to create a low frequency refractory wave envelope. The low frequency wave inhibits or stimulates local neurons to control electrical activity within that region.

Abstract: The present invention provides a wearable device, a system for manufacturing a wearable device and a method of neural activity control. The device for temporal interference simulation includes a pair of electrodes at penalizable location. The electrodes each send out a high frequency electromagnetic fields with a very slight difference in the two frequencies. The fields superimpose at a specified region of the brain, which is customized depending on the location of neural activity control, to create a low frequency refractory wave envelope. The low frequency wave inhibits or stimulates local neurons to control electrical activity within that region.