Abstract: Embodiments provided herein, provide for variant IgG Fc polypeptides, dimeric molecules, pharmaceutical compositions, and methods that can be used to target at cells to modulate the activity of the same to treat disorders, such as autoimmune disorders or cancers.

Abstract: The present application provides for IL-2 muteins, compositions comprising the same, and methods of using the same.

Abstract: Systems and methods may provide recommendations for a circuit design based on components of the circuit and machine-learning techniques. For example, a system may include a processor-based device storing or accessing a computer-aided design application for an integrated circuit, where the computer-aided design application, when executed by the processor-based device, causes acts to be performed including receiving an indication of a first selected component from a library for a design for the integrated circuit, retrieving one or more suggested components from the library based at least in part on the first selected component, and populating a user interface with the first selected component and a first suggested component of the one or more suggested components for display on the processor-based device.

Abstract: Artificial intelligence (AI) technology can be used in combination with composable communication goal statements to facilitate a user's ability to quickly structure story outlines using “explanation” communication goals in a manner usable by an NLG narrative generation system without any need for the user to directly author computer code. This AI technology permits NLG systems to determine the appropriate content for inclusion in a narrative story about a data set in a manner that will satisfy a desired explanation communication goal such that the narratives will express various ideas that are deemed relevant to a given explanation communication goal.

Abstract: The present application provides for IL-2 muteins, compositions comprising the same, and methods of using the same.

Abstract: Disclosed herein are methods of producing glyco-modified viral antigens that provide a shift of the glycosylation profile of recombinant produced viral antigens (e.g. glycoproteins) towards the naturally occurring viral antigens (e.g. glycoproteins). Disclosed are methods of producing a modified viral antigen comprising expressing a viral antigen in a recombinant mammalian cell line having one or more of the endogenous genes Mgat2, Mgat4A, Mgat4B, Mgat5, St3Gal3, St3Gal4, B4galt1, B4galt2, B4galt3, B4galt4, B4galt5, B3gnt2, St3Gal6, SPPL3, and/or FUT8 inactivated and/or downregulated; and optionally a gene ST6Gall inserted. Disclosed are glyco-modified viral antigens produced by the method of using a recombinant mammalian cell line. Disclosed are methods of treating a subject in need thereof comprising administering a composition comprising a therapeutically effective amount of one or more of the glyco-modified viral antigens.

Abstract: Densified textile aggregates are co-fed with a fuel into a partial oxidation gasifier. High solids concentrations in the feedstock composition can be obtained without significant impact on the feedstock composition stability and pumpability. A consistent quality of densified textile derived syngas can be continuously produced, including generation of carbon dioxide and a carbon monoxide/hydrogen ratio while stably operating the gasifier and avoiding the high tar generation of fluidized bed or fixed bed waste gasifiers and without impacting the operations of the gasifier. The densified textile derived syngas quality, composition, and throughput are suitable for produce a wide range of chemicals and polymers, including methanol, acetic acid, methyl acetate, acetic anhydride, and cellulose esters through a variety of reaction schemes in which at least a portion of the chemical or polymer originates with densified textile derived syngas.

Abstract: Pre-ground plastics of small particle size not more than 2 mm are co-fed into a solid fossil fuel fed entrained flow partial oxidation gasifier. High solids concentrations in the feedstock stream can be obtained without significant impact on the feedstock stream stability and pumpability. A consistent quality of syngas can be continuously produced, including generation of carbon dioxide and a carbon monoxide/hydrogen ratio while stably operating the gasifier and avoiding the high tar generation of fluidized bed or fixed bed waste gasifiers and without impacting the operations of the gasifier. The subsequent syngas produced from this material can be used to produce a wide range of chemicals.

Abstract: Pre-ground plastics of small particle size not more than 2 mm are co-fed into a solid fossil fuel fed entrained flow partial oxidation gasifier. High solids concentrations in the feedstock stream can be obtained without significant impact on the feedstock stream stability and pumpability. A consistent quality of syngas can be continuously produced, including generation of carbon dioxide and a carbon monoxide/hydrogen ratio while stably operating the gasifier and avoiding the high tar generation of fluidized bed or fixed bed waste gasifiers and without impacting the operations of the gasifier. The subsequent syngas produced from this material can be used to produce a wide range of chemicals.

Abstract: An insert for supplying a fluid to splines of a drive shaft, the insert comprising an insert wall extending between a first end and a second end of the insert, a chamber surrounding the insert wall for storing a fluid, a piston having a surface configured to be exposed to the fluid, the piston configured to move between a first position and a second position within the chamber, and the piston biased toward the first position, and wherein an increase in supply of the fluid in the chamber causes the piston to move toward the second position and a decrease in supply of the fluid in the chamber causes the piston to move toward the first position.

Abstract: An insert for supplying a fluid to splines of a drive shaft, the insert extending along an axis of rotation, and the insert comprising an insert wall extending along the axis of rotation, a reservoir defined by the insert wall for storing a fluid, an elastically deformable portion, the elastically deformable portion capable of transitioning between an expanded state and an unexpanded state, and wherein the elastically deformable portion is configured to expand to the expanded state in a radial direction with respect to the axis of rotation when the fluid is supplied to the reservoir during rotation of the insert and to contract to the unexpanded state when rotation of the insert and supply of the fluid to the reservoir are ceased.

Abstract: There is provided a method for authenticating the proximity of at least two devices, the method comprising: generating at least one packet; emitting at least one acoustic wave from at least one emitting device, each acoustic wave corresponding to a generated packet, at least one acoustic wave being emitted for all the generated packets, all the emitted acoustic waves forming an acoustic wave superposition. The superposition is received with at least one receiving device; assessing the similarity of the received superposition and a comparator; and authenticating proximity of each emitting device and each receiving device when the received superposition and the comparator fulfil a predetermined similarity requirement, wherein the comparator corresponds to a combination of all the generated packets.

Abstract: Disclosed are toric accommodating intraocular lenses. In one embodiment, a toric accommodating intraocular lens comprises an anterior element and a posterior element. The anterior element can comprise an anterior optical surface. The posterior element can comprise a posterior optical surface. A fluid-filled optic fluid chamber can be defined in between the anterior element and the posterior element. The toric accommodating intraocular lens can be configured to correct for corneal astigmatism, spherical aberration, or a combination thereof.

Abstract: A transformative method to profile the glycome in individual cells by leveraging computational biology tools with lectin or similar profiling technologies. Robust and accurate reconstruction glycomes with high-resolution glycan structure information for biological samples, including at the single cell level. Tools such as single-clone analysis andjoint-clone analysis, which may be used to assist researchers in analyzing single cell glycoprofiled samples, which identify how glycosylation variation across cells impact the cellular phenotypes. Single cell glycoprofiling using lectins is practically implemented to provide high resolution of the glycan structure information. Glycan profiling techniques having a wide range of biological applications from embryonic development to cancer and infectious disease due to high throughput, low cost, and robust reliability.

Abstract: Methods and compositions for diagnosing, preventing or treating a viral infection in a subject comprising administering to a subject in need thereof an effective amount of a glycosidase or a sulfatase to degrade a glycan, such as heparan sulfate, to inhibit viral infection, such as COVID-19. Methods for identifying a glycosidase, a sulfatase, or a microbe associated with increased susceptibility to viral infection in a subject.

Abstract: Disclosed are toric accommodating intraocular lenses. In one embodiment, a toric accommodating intraocular lens comprises an anterior element and a posterior element. The anterior element can comprise an anterior optical surface. The posterior element can comprise a posterior optical surface. A fluid-filled optic fluid chamber can be defined in between the anterior element and the posterior element. The toric accommodating intraocular lens can be configured to correct for corneal astigmatism, spherical aberration, or a combination thereof.

Abstract: An insert for supplying a fluid within a drive shaft, the insert extending along an axis of rotation and comprising an insert wall having a rigid inner insert wall portion and an elastically deformable outer insert wall portion a reservoir defined by the insert wall for storing a fluid, a nozzle positioned at the first end of the insert wall, and wherein the elastically deformable outer insert wall portion is configured to move between an expanded state, when the fluid is supplied to the reservoir, and an unexpanded state, when rotation of the insert and supply of fluid to the reservoir are ceased, and movement of the elastically deformable outer insert wall portion to the unexpanded state forces the fluid to be discharged through the nozzle.

Abstract: Disclosed are adjustable accommodating intraocular lenses and methods of adjusting accommodating intraocular lenses post-operatively. In one embodiment, an adjustable accommodating intraocular lens comprises an optic portion and a peripheral portion. At least one of the optic portion and the peripheral portion can be made in part of a composite material comprising an energy absorbing constituent and a plurality of expandable components. At least one of a base power and a cylindricity of the optic portion can be configured to change in response to an external energy directed at the composite material.

Abstract: Disclosed are adjustable accommodating intraocular lenses and methods of adjusting accommodating intraocular lenses post-operatively. In one embodiment, an adjustable accommodating intraocular lens comprises an optic portion and a peripheral portion. At least one of the optic portion and the peripheral portion can be made in part of a composite material comprising an energy absorbing constituent and a plurality of expandable components. At least one of a base power and a cylindricity of the optic portion can be configured to change in response to an external energy directed at the composite material.

Abstract: An intraocular lens is disclosed that includes an optic body with a projection extending radially outwards from a peripheral surface of the optic body. The projection comprises a haptic contact surface facing radially outward, wherein the entire haptic contact surface is a flat surface. A haptic having a free distal end and a proximal portion is secured to the projection along the haptic contact surface, wherein the projection and the proximal portion interface at a butt joint without the haptic extending into the projection and without the projection extending into the haptic. The haptic also includes a haptic fluid chamber.