Abstract: Ankle orthoses include a fabric portion having closure flaps, a rigid upright assembly having at least a portion disposed within the fabric portion, and at least one adjustable cuff assembly configured to encircle the lower leg of the wearer above the ankle over the fabric portion and apply medial-lateral force to the lower leg of the wearer, thereby, preventing a tibia and fibula of the wearer from separating. The orthosis includes a first fastener coupled to a side of the orthosis at a position inferior of the ankle joint of the wearer; and a first midfoot strap configured to wrap at least partly around the midfoot of the wearer over the fabric portion and having a first end coupled to the same position on the side of the orthosis as the first fastener, and a second end configured to couple to the first fastener. Additional orthoses and methods are provided.

Abstract: A microfluidic device for modeling a tumor-immune microenvironment can include a multiwell plate defining a plurality of microenvironment units fluidically coupled with a plurality of wells. Each microenvironment unit of the plurality of microenvironment units can include one or more compartments. Each microenvironment unit can include a trapping feature positioned within the one or more compartments. The trapping feature can be defined by a portion of at least one of a sidewall or a floor of the one or more compartments. The trapping feature can restrict movement of a tissue sample introduced into the one or more compartments and to allow fluid to flow past the tissue sample. The microfluidic device can include a plurality of micropumps each coupled with a respective well and configured to control movement of a respective fluid sample through each respective well.

Abstract: A computer-implemented method, that when executed on data processing hardware, causes the data processing hardware to perform operations at a hollow fiber transduction device. The operations include instructing a pump of the hollow fiber transduction device to execute one of the steps of the recipe to provide a first pressure at a first sensor where the first pressure is specified in the recipe. The operations also include receiving, from a first sensor of the hollow fiber transduction device, a fluid flow signal that indicates an operating parameter measured at the first sensor, comparing a first end trigger threshold of the one of the steps of the recipe against the received fluid flow signal, and instructing the pump to complete the one of the steps of the recipe based on the first end trigger threshold comparison.

Abstract: This disclosure describes techniques for fabricating a high-resolution, non-cytotoxic and transparent microfluidic device. A material can be selected based on having an optical property with a predetermined degree of transparency to provide viewability of a biological sample through the microfluidic device and a level of cytotoxicity within a predetermined threshold to provide viability of the biological sample within the microfluidic device. An additive manufacturing technique can be selected from a plurality of additive manufacturing techniques for fabricating the microfluidic device based on the selected material to provide a resolution of dimensions of one or more channels of the microfluidic device higher than a predetermined resolution threshold.

Abstract: This disclosure describes microfluidic tissue biopsy and immune response drug evaluation devices and systems. A microfluidic device can include an inlet channel having a first end configured to receive a fluid sample optionally containing a tissue sample. The microfluidic device can also include a tissue trapping region at the second end of the inlet channel downstream from the first end. The tissue trapping region can include one or more tissue traps configured to catch a tissue sample flowing through the inlet channel such that the fluid sample contacts the tissue trap. The microfluidic device can also include one or more channels providing an outlet.

Abstract: This disclosure describes microfluidic tissue biopsy and immune response drug evaluation devices and systems. A microfluidic device can include an inlet channel having a first end configured to receive a fluid sample optionally containing a tissue sample. The microfluidic device can also include a tissue trapping region at the second end of the inlet channel downstream from the first end. The tissue trapping region can include one or more tissue traps configured to catch a tissue sample flowing through the inlet channel such that the fluid sample contacts the tissue trap. The microfluidic device can also include one or more channels providing an outlet.

Abstract: A system for introducing a vector into includes a filter module defining an intra-capillary space and an extra-capillary space separated from the intra-capillary space by a porous membrane. The system also includes a pair of intra-capillary ports fluidly coupled to opposite ends of the intra-capillary space and each receiving a transduction media, cells, and a vector. The system also includes a pair of extra-capillary ports coupled to opposite ends of the extra-capillary space and in fluid-communication with a source of extra-capillary media and a waste container.

Abstract: The present disclosure relates to a pharmaceutical combination comprising (a) a histone deacetylase 6 inhibitor and (b) a BCL-2 inhibitor, including combined preparations and pharmaceutical compositions thereof; uses of such combination in the treatment or prevention of cancer; and methods of treating or preventing cancer in a subject comprising administering a therapeutically effective amount of such combination.

Abstract: A network outage and redundancy module which provides improved security, platform independence and continuity in information between financial hardware and enterprise applications.

Abstract: A system is provided. The system includes a patient analysis (“PA”) computer device including at least one processor in communication with at least one memory device. The at least one processor is programmed to a) store a patient analysis model, b) receive a patent identifier associated with the patient; c) retrieve a plurality of claim information associated with the patient identifier; d) retrieve a plurality of electronic healthcare records (EHR) associated with the patient identifier; e) execute the patient analysis model to determine a patient risk score based on the plurality of claim information and the plurality of EHR; and f) present information about the patient to a healthcare provider.

Abstract: This disclosure describes techniques for fabricating a high-resolution, non-cytotoxic and transparent microfluidic device. A material can be selected based on having an optical property with a predetermined degree of transparency to provide viewability of a biological sample through the microfluidic device and a level of cytotoxicity within a predetermined threshold to provide viability of the biological sample within the microfluidic device. An additive manufacturing technique can be selected from a plurality of additive manufacturing techniques for fabricating the microfluidic device based on the selected material to provide a resolution of dimensions of one or more channels of the microfluidic device higher than a predetermined resolution threshold.

Abstract: This disclosure describes microfluidic tissue biopsy and immune response drug evaluation devices and systems. A microfluidic device can include an inlet channel having a first end configured to receive a fluid sample optionally containing a tissue sample. The microfluidic device can also include a tissue trapping region at the second end of the inlet channel downstream from the first end. The tissue trapping region can include one or more tissue traps configured to catch a tissue sample flowing through the inlet channel such that the fluid sample contacts the tissue trap. The microfluidic device can also include one or more channels providing an outlet.

Abstract: This disclosure describes techniques for fabricating a high-resolution, non-cytotoxic and transparent microfluidic device. A material can be selected based on having an optical property with a predetermined degree of transparency to provide viewability of a biological sample through the microfluidic device and a level of cytotoxicity within a predetermined threshold to provide viability of the biological sample within the microfluidic device. An additive manufacturing technique can be selected from a plurality of additive manufacturing techniques for fabricating the microfluidic device based on the selected material to provide a resolution of dimensions of one or more channels of the microfluidic device higher than a predetermined resolution threshold.

Abstract: A network outage and redundancy module which provides improved security, platform independence and continuity in information between financial hardware and enterprise applications.

Abstract: A network outage and redundancy module which provides improved security, platform independence and continuity in information between financial hardware and enterprise applications.

Abstract: A system for efficient allocation of resources in a financial services branch includes a branch computer system and a remote solutions server which are in communication with a core banking server. The branch computer system includes various computer, network devices and equipment for branch operations. A plurality of customer devices, such as smartphones and tablet computers, can be connected to a remote solutions server. Each such device can be pre-configured with a remote banking application (“app”) allowing a respective customer to use the device to communicate with the remote solutions server to perform the remote banking. The remote solutions server facilitates remote banking wherein transactions can be completed using in-branch banking equipment. Additionally, the banking customer may schedule time with banking personnel using this application, wherein the meeting can take place at the same branch where the transaction will be completed.

Abstract: A microfluidic device for modeling a tumor-immune microenvironment can include a multiwell plate defining a plurality of microenvironment units fluidically coupled with a plurality of wells. Each microenvironment unit of the plurality of microenvironment units can include one or more compartments. Each microenvironment unit can include a trapping feature positioned within the one or more compartments. The trapping feature can be defined by a portion of at least one of a sidewall or a floor of the one or more compartments. The trapping feature can restrict movement of a tissue sample introduced into the one or more compartments and to allow fluid to flow past the tissue sample. The microfluidic device can include a plurality of micropumps each coupled with a respective well and configured to control movement of a respective fluid sample through each respective well.

Abstract: This disclosure describes microfluidic tissue biopsy and immune response drug evaluation devices and systems. A microfluidic device can include an inlet channel having a first end configured to receive a fluid sample optionally containing a tissue sample. The microfluidic device can also include a tissue trapping region at the second end of the inlet channel downstream from the first end. The tissue trapping region can include one or more tissue traps configured to catch a tissue sample flowing through the inlet channel such that the fluid sample contacts the tissue trap. The microfluidic device can also include one or more channels providing an outlet.

Abstract: This disclosure describes techniques for fabricating a high-resolution, non-cytotoxic and transparent microfluidic device. A material can be selected based on having an optical property with a predetermined degree of transparency to provide viewability of a biological sample through the microfluidic device and a level of cytotoxicity within a predetermined threshold to provide viability of the biological sample within the microfluidic device. An additive manufacturing technique can be selected from a plurality of additive manufacturing techniques for fabricating the microfluidic device based on the selected material to provide a resolution of dimensions of one or more channels of the microfluidic device higher than a predetermined resolution threshold.

Abstract: The present disclosure relates to a system that includes at least one information kiosk, a server connected to the at least one information kiosk, a local network, and a plurality of browser-enabled computing devices connected to the server via the local network; wherein, the server is configured to alert one or more of the browser-enabled computing devices regarding a user of the information kiosk. The information kiosk is navigable, preferably by touch using a touch screen. In an embodiment, the touch screen includes at least one help widget that a user can select so as to be provided with assistance in real time. Browser-enabled computing device users have the opportunity to review assistance requests in the customer alert queue, and either accept or reject the assistance requests. In another embodiment, the system can generate strategic alerts without an express request for assistance from the user of the information kiosk.