Abstract: Techniques described herein may enable implementation of systems and devices (e.g. user computers, server devices, clusters of servers, etc.) that determine, create, execute, monitor, and manage coupled and customized transactions involving indefinite, yield- and risk-based instruments with optionality to enhance organizational value and create incentive alignment between transacting entities (e.g. individuals, organizations, and other types of entities) not otherwise disposed to collaboration.

Abstract: A method for profiling extracellular vesicles (EV) is provided.

Abstract: An apparatus and method for advancement of a spinal rod in a spinal implant, wherein the apparatus includes a body and a handle attached to the body. A shaft is slidably attached to the body, the shaft is coupled to the handle and has a first end adapted to engage the spinal rod. At least one retractor blade is attached to the body and the spinal implant. The operation of the handle results in the shaft persuading the spinal rod in the spinal implant. The force exerted by the shaft on the spinal rod is limited to a pre-selected force. The apparatus can also be operated in a non-limiting mode when a reduction retractor blade is used.

Abstract: A revisable intervertebral implant may include two end plates designed to detachably receive a variety of intermediate components including articulating bearing inserts, elastic inserts, and fusion blocks. Each intermediate component may be secured to a snap insert that snaps into engagement with the corresponding end plate in response to pressure urging the intermediate component toward the end plate along a cephalad-caudal direction. The end plates may first be secured to the corresponding vertebral bodies, and then the intermediate component(s) may be snapped into locking engagement with the implanted end plates to complete in-situ assembly of the intervertebral implant. The implant may easily be revised by snapping the intermediate component(s) out of engagement with the end plates, removing the intermediate component(s), inserting the new intermediate component(s) into the space between the end plates, and snapping the new intermediate component(s) into engagement with the end plates.

Abstract: A revisable intervertebral implant may include two end plates designed to detachably receive a variety of intermediate components including articulating bearing inserts, elastic inserts, and fusion blocks. Each intermediate component may be secured to a snap insert that snaps into engagement with the corresponding end plate in response to pressure urging the intermediate component toward the end plate along a cephalad-caudal direction. The end plates may first be secured to the corresponding vertebral bodies, and then the intermediate component(s) may be snapped into locking engagement with the implanted end plates to complete in-situ assembly of the intervertebral implant. The implant may easily be revised by snapping the intermediate component(s) out of engagement with the end plates, removing the intermediate component(s), inserting the new intermediate component(s) into the space between the end plates, and snapping the new intermediate component(s) into engagement with the end plates.

Abstract: An apparatus and method for advancement of a spinal rod in a spinal implant, wherein the apparatus includes a body and a handle attached to the body. A shaft is slidably attached to the body, the shaft is coupled to the handle and has a first end adapted to engage the spinal rod. At least one retractor blade is attached to the body and the spinal implant. The operation of the handle results in the shaft persuading the spinal rod in the spinal implant. The force exerted by the shaft on the spinal rod is limited to a pre-selected force. The apparatus can also be operated in a non-limiting mode when a reduction retractor blade is used.

Abstract: The present invention provides an intervertebral implant for replacing intervertebral disc material and controlling relative motion between adjacent vertebral bodies. The intervertebral implant may have at least one end plate and an intermediate component which slides into engagement with the end plate. The intermediate component may be engageable with the end plate from an anterior approach, or a right or left lateral approach. The intermediate component can be a set of bearing surfaces which articulate to provide relative motion between two vertebral bodies, an elastic insert which deforms to provide motion between two vertebral bodies, or a rigid insert which prevents relative motion between two vertebral bodies. The intermediate component is replaceable with a different intermediate component which provides a different function. The present invention also provides one or more retaining members which snap into engagement with the end plate and secure the intermediate component to the end plate.

Abstract: A revisable intervertebral implant may include two end plates designed to detachably receive a variety of intermediate components including articulating bearing inserts, elastic inserts, and fusion blocks. Each intermediate component may be secured to a snap insert that snaps into engagement with the corresponding end plate in response to pressure urging the intermediate component toward the end plate along a cephalad-caudal direction. The end plates may first be secured to the corresponding vertebral bodies, and then the intermediate component(s) may be snapped into locking engagement with the implanted end plates to complete in-situ assembly of the intervertebral implant. The implant may easily be revised by snapping the intermediate component(s) out of engagement with the end plates, removing the intermediate component(s), inserting the new intermediate component(s) into the space between the end plates, and snapping the new intermediate component(s) into engagement with the end plates.