Abstract: A gas spring-powered fastener driver includes a cylinder, a moveable piston positioned within the cylinder, a driver blade attached to the piston and movable therewith between a ready position and a driven position, a lifter to move the driver blade from the driven position to the ready position, and a transmission including an output shaft operatively coupled to the lifter to provide torque to the lifter. The fastener driver also includes an input to provide torque to the transmission and a clutch positioned downstream of the input and operably coupled to the output shaft to limit an amount of torque transferred to the output shaft and the lifter. In response to an application of a reaction torque to the output shaft above a predetermined threshold, torque from the input is diverted from the output shaft via the clutch.

Abstract: The invention provides recombinant Roundabout Receptor 2 (ROBO2) proteins designed to bind SLIT ligands and prevent their binding to ROBO2 cell surface receptors. Also provided are methods for use of these recombinant ROBO2 proteins.

Abstract: A gas spring-powered fastener driver includes a cylinder, a moveable piston positioned within the cylinder, a driver blade attached to the piston and movable therewith between a ready position and a driven position, a lifter to move the driver blade from the driven position to the ready position, and a transmission including an output shaft operatively coupled to the lifter to provide torque to the lifter. The fastener driver also includes an input to provide torque to the transmission and a clutch positioned downstream of the input and operably coupled to the output shaft to limit an amount of torque transferred to the output shaft and the lifter. In response to an application of a reaction torque to the output shaft above a predetermined threshold, torque from the input is diverted from the output shaft via the clutch.

Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto.