Abstract: The present invention is directed to methods for determining the presence or absence of a genetic defect in an IVF embryo prior to transfer comprising performing real-time PCR and 2???CT analyses to determine normalized copy number of at least one invariant locus on at least one chromosome collected from at least one cell of the embryo and selecting a candidate IVF embryo determined to be without genetic defect for transfer.

Abstract: The present invention is directed to methods for determining the presence or absence of a genetic defect in an IVF embryo prior to transfer comprising identifying a set of informative SNPs in the genotype of the embryo's parents; assaying the genotype of two or more informative SNPs from the set of informative SNPs on one or more chromosomes collected from a cell of the embryo; determining the presence or absence of a genetic defect in the embryo based on the genotype of the two or more informative SNPs on one or more chromosomes of the embryo; and selecting a candidate IVF embryo determined to be without genetic defect for transfer.

Abstract: Methods of in vitro fertilization wherein said method includes preimplantation genetic diagnosis of all 24 chromosomes of an IVF embryo comprising whole genome amplification and SNP-based microarray analyses are disclosed.