Abstract: The present disclosure provides methods, kits, and therapeutic molecules for evaluating and treating patients with IPF and subtypes of IPF. Specifically, the present disclosure provides a method for diagnosing a patient with IPF and subtypes of IPF based on the expression profile of small, non-coding RNA biomarkers. The present disclosure also provides therapeutic molecules that target the dysregulated sRNAs of the expression profile. In some aspects and embodiments, the disclosure provides miR-92a-3p isoforms and compounds that mimic the action of miR-92a-3p or its isoforms for use in therapy, including but not limited to therapy for IPF.

Abstract: Cell deposition and staining apparatuses and methods are disclosed herein. In particular, the deposition and staining apparatuses disclosed herein provide low-volume, automated bench top systems for depositing and staining cellular samples on a cytological slide. An example deposition and staining apparatus includes a housing having an access door; a substrate processing holder located within the housing configured to hold one or more substrates and/or one or more substrate cartridges, wherein the substrate processing holder is accessible when the access door is in an open configuration; at least one opening located at least partially above at least a portion of the substrate processing holder; a spray nozzle configured to dispense a gaseous substance into the substrate processing area; a user interface configured receive an input from a user, and in response to receiving the input, cause execution of a pre-programmed protocol; and a waste and/or reagent holder element.

Abstract: Cell deposition and staining apparatuses and methods are disclosed herein. In particular, the deposition and staining apparatuses disclosed herein provide low-volume, automated bench top systems for depositing and staining cellular samples on a cytological slide. An example deposition and staining apparatus includes a housing having an access door; a substrate processing holder located within the housing configured to hold one or more substrates and/or one or more substrate cartridges, wherein the substrate processing holder is accessible when the access door is in an open configuration; at least one opening located at least partially above at least a portion of the substrate processing holder; a spray nozzle configured to dispense a gaseous substance into the substrate processing area; a user interface configured receive an input from a user, and in response to receiving the input, cause execution of a pre-programmed protocol; and a waste and/or reagent holder element.

Abstract: Cell deposition and staining apparatuses and methods are disclosed herein. In particular, the deposition and staining apparatuses disclosed herein provide low-volume, automated bench top systems for depositing and staining cellular samples on a cytological slide. An example deposition and staining apparatus includes a housing having an access door; a substrate processing holder located within the housing configured to hold one or more substrates and/or one or more substrate cartridges, wherein the substrate processing holder is accessible when the access door is in an open configuration; at least one opening located at least partially above at least a portion of the substrate processing holder; a spray nozzle configured to dispense a gaseous substance into the substrate processing area; a user interface configured receive an input from a user, and in response to receiving the input, cause execution of a pre-programmed protocol; and a waste and/or reagent holder element.

Abstract: Cell deposition and staining apparatuses and methods are disclosed herein. In particular, the deposition and staining apparatuses disclosed herein provide low-volume, automated bench top systems for depositing and staining cellular samples on a cytological slide. An example deposition and staining apparatus includes a housing having an access door; a substrate processing holder located within the housing configured to hold one or more substrates and/or one or more substrate cartridges, wherein the substrate processing holder is accessible when the access door is in an open configuration; at least one opening located at least partially above at least a portion of the substrate processing holder; a spray nozzle configured to dispense a gaseous substance into the substrate processing area; a user interface configured receive an input from a user, and in response to receiving the input, cause execution of a pre-programmed protocol; and a waste and/or reagent holder element.

Abstract: Cell deposition and staining apparatuses and methods are disclosed herein. In particular, the deposition and staining apparatuses disclosed herein provide low-volume, automated bench top systems for depositing and staining cellular samples on a cytological slide. An example deposition and staining apparatus includes a housing having an access door; a substrate processing holder located within the housing configured to hold one or more substrates and/or one or more substrate cartridges, wherein the substrate processing holder is accessible when the access door is in an open configuration; at least one opening located at least partially above at least a portion of the substrate processing holder; a spray nozzle configured to dispense a gaseous substance into the substrate processing area; a user interface configured receive an input from a user, and in response to receiving the input, cause execution of a pre-programmed protocol; and a waste and/or reagent holder element.

Abstract: The present invention provides a device (10) for the extraction of machining dust. The device (10) comprises a body (12) configured to be coupled to a section of a machining machine. The body (12) having a first opening (11) at a first end thereof and a second opening (13) at a second end thereof. The first end is opposite the second end, and the first opening (11) is configured to receive a tool holder therethrough and the second opening (13) configured to receive a cutting tool therethrough. The device also comprises a Venturi mechanism (14) connected to the body (12) and in fluid communication with said second opening (13). The Venturi mechanism (14) is configured to facilitate the suction of machining dust through the second opening (13) and through the Venturi mechanism (14).

Abstract: Cell deposition and staining apparatuses and methods are disclosed herein. In particular, the deposition and staining apparatuses disclosed herein provide low-volume, automated bench top systems for depositing and staining cellular samples on a cytological slide. An example deposition and staining apparatus includes a housing having an access door; a substrate processing holder located within the housing configured to hold one or more substrates and/or one or more substrate cartridges, wherein the substrate processing holder is accessible when the access door is in an open configuration; at least one opening located at least partially above at least a portion of the substrate processing holder; a spray nozzle configured to dispense a gaseous substance into the substrate processing area; a user interface configured receive an input from a user, and in response to receiving the input, cause execution of a pre-programmed protocol; and a waste and/or reagent holder element.

Abstract: A rotary table (10a) for a milling machine, comprising sensing means (30,32) configured to measure and/or calculate a clearance between two mating components of said rotary table (10a), and transmission means configured to transmit said measured/calculated clearance to a central processing unit. The mating components of the rotary table being a worm screw and a worm wheel.

Abstract: The present invention provides a device (10) for the extraction of machining dust. The device (10) comprises a body (12) configured to be coupled to a section of a machining machine. The body (12) having a first opening (11) at a first end thereof and a second opening (13) at a second end thereof. The first end is opposite the second end, and the first opening (11) is configured to receive a tool holder therethrough and the second opening (13) configured to receive a cutting tool therethrough. The device also comprises a Venturi mechanism (14) connected to the body (12) and in fluid communication with said second opening (13). The Venturi mechanism (14) is configured to facilitate the suction of machining dust through the second opening (13) and through the Venturi mechanism (14).

Abstract: A rotary table (10a) for a milling machine, comprising sensing means (30,32) configured to measure and/or calculate a clearance between two mating components of said rotary table (10a), and transmission means configured to transmit said measured/calculated clearance to a central processing unit. The mating components of the rotary table being a worm screw and a worm wheel.

Abstract: An apparatus and method for applying reagents to tissue mounted on slides, in the field of histology is disclosed. The apparatus holds a number of slides, in slide trays, which are loaded onto the apparatus. Each slide tray forms a batch of slides, with all the batched forming a group. The apparatus holds a number of reagents, grouped into a first group comprising bulk type reagents, and a second group comprising antibodies or probes, and detection systems, for identifying elements of the tissue. A group fluid dispenser, in the form of a robot arm, dispense reagents to the group of slides. Each batch of slides has its own batch fluid dispenser to dispense reagents onto the batch of slides. In on embodiment, the group fluid dispenser dispense antibodies, probes, detection reagents to all slides depending on the protocol defined for each slide, and the batch dispensers dispense bulk reagent to each batch, thus freeing the group fluid dispense from dispensing bulk reagents to all slides.