Abstract: A method for loading a stack of interfolded paper units into a dispenser includes inserting a stack of interfolded paper units into an interior volume of the dispenser through a dispenser opening. The dispenser has a lid having a dispensing aperture, as well as a movable platen that has a paper-engaging surface, and which is urged upwardly toward the dispenser opening. A bottom wall of the dispenser is disposed opposite the dispenser opening, and a lock of the dispenser is selectively engageable with the platen. The stack is placed on the platen and a downward force is exerted on the top surface of the stack to thereby push the platen downward until the platen has been engaged by the lock and has reached a locked position in which the paper-engaging surface has an oblique orientation relative to the bottom wall of the dispenser.

Abstract: Embodiments provided herein, provide for polypeptides and molecules comprising a polypeptide having protease activity and a variant Fc molecule, pharmaceutical compositions comprising the same, and methods that can be used to treat disorders, such as IgG mediated disorders.

Abstract: Embodiments provided herein, provide for polypeptides and molecules comprising a polypeptide having protease activity and a variant Fc molecule, pharmaceutical compositions comprising the same, and methods that can be used to treat disorders, such as IgG mediated disorders.

Abstract: The present disclosure relates to systems, non-transitory computer-readable media, and methods for utilizing machine learning and digital embedding processes to generate digital maps of biology and user interfaces for evaluating map efficacy. In particular, in one or more embodiments, the disclosed systems receive perturbation data for a plurality of perturbation experiment units corresponding to a plurality of perturbation classes. Further, the systems generate, utilizing a machine learning model, a plurality of perturbation experiment unit embeddings from the perturbation data. Additionally, the systems align, utilizing an alignment model, the plurality of perturbation experiment unit embeddings to generate aligned perturbation unit embeddings. Moreover, the systems aggregate the aligned perturbation unit embeddings to generate aggregated embeddings. Furthermore, the systems generate perturbation comparisons utilizing the perturbation-level embeddings.

Abstract: The present disclosure relates to systems, non-transitory computer-readable media, and methods for utilizing machine learning and digital embedding processes to generate digital maps of biology and user interfaces for evaluating map efficacy. In particular, in one or more embodiments, the disclosed systems receive perturbation data for a plurality of perturbation experiment units corresponding to a plurality of perturbation classes. Further, the systems generate, utilizing a machine learning model, a plurality of perturbation experiment unit embeddings from the perturbation data. Additionally, the systems align, utilizing an alignment model, the plurality of perturbation experiment unit embeddings to generate aligned perturbation unit embeddings. Moreover, the systems aggregate the aligned perturbation unit embeddings to generate aggregated embeddings. Furthermore, the systems generate perturbation comparisons utilizing the perturbation-level embeddings.

Abstract: Embodiments provided herein, provide for polypeptides and molecules comprising a polypeptide having protease activity and a variant Fc molecule, pharmaceutical compositions comprising the same, and methods that can be used to treat disorders, such as IgG mediated disorders.

Abstract: Embodiments provided herein, provide for polypeptides and molecules comprising a polypeptide having protease activity and a variant Fc molecule, pharmaceutical compositions comprising the same, and methods that can be used to treat disorders, such as IgG mediated disorders.

Abstract: An injector includes a push rod, a magazine tube, a gate, a cannula and an actuator. The magazine tube has a lumen extending from an inlet to an outlet thereof. The magazine tube slidingly receives at least one implant therein. The gate has a closed configuration in which it covers the outlet of the magazine tube and an open configuration in which it does not cover the outlet of the magazine tube. The cannula has a distal end configured to be inserted into an eye. A lumen of the cannula is in fluid communication with the lumen of the magazine tube when the gate is in the open configuration. Actuation of the actuator moves the gate from the closed configuration to the open configuration and causes translation of the pushrod through the magazine tube and the cannula.

Abstract: A needling device may be used for needling of a subject's skin, and a drug applicator device may be used for applying a drug to a subject's skin. For example, a needling device may be applied to a subject's skin for hair growth applications, or may be used for wrinkle, scar, or tattoo removal. A drug applicator device may be used for multiple drug application purposes such as applying a hair growth compound to the skin of a subject.

Abstract: A needling device may be used for needling of a subject's skin, and a drug applicator device may be used for applying a drug to a subject's skin. For example, a needling device may be applied to a subject's skin for hair growth applications, or may be used for wrinkle, scar, or tattoo removal. A drug applicator device may be used for multiple drug application purposes such as applying a hair growth compound to the skin of a subject.

Abstract: A method for loading a stack of interfolded paper units into a dispenser includes inserting a stack of interfolded paper units into an interior volume of the dispenser through a dispenser opening. The dispenser has a lid having a dispensing aperture, as well as a movable platen that has a paper-engaging surface, and which is urged upwardly toward the dispenser opening. A bottom wall of the dispenser is disposed opposite the dispenser opening, and a lock of the dispenser is selectively engageable with the platen. The stack is placed on the platen and a downward force is exerted on the top surface of the stack to thereby push the platen downward until the platen has been engaged by the lock and has reached a locked position in which the paper-engaging surface has an oblique orientation relative to the bottom wall of the dispenser.

Abstract: A method for loading a stack of interfolded paper units into a dispenser includes inserting a stack of interfolded paper units into an interior volume of the dispenser through a dispenser opening. The dispenser has a lid having a dispensing aperture, as well as a movable platen that has a paper-engaging surface, and which is urged upwardly toward the dispenser opening. A bottom wall of the dispenser is disposed opposite the dispenser opening, and a lock of the dispenser is selectively engageable with the platen. The stack is placed on the platen and a downward force is exerted on the top surface of the stack to thereby push the platen downward until the platen has been engaged by the lock and has reached a locked position in which the paper-engaging surface has an oblique orientation relative to the bottom wall of the dispenser.

Abstract: A needling device may be used for needling of a subject's skin, and a drug applicator device may be used for applying a drug to a subject's skin. For example, a needling device may be applied to a subject's skin for hair growth applications, or may be used for wrinkle, scar, or tattoo removal. A drug applicator device may be used for multiple drug application purposes such as applying a hair growth compound to the skin of a subject.

Abstract: A system and method for teaching a user to discriminate and match musical pitch is disclosed. A pitch module generates a first melodic sequence for a user. The pitch module generates at least two symbolically depicted sequences including a first symbolic sequence that represents a pitch frequency that, when played, matches the first melodic sequence. A tracking module receives a selection of the first symbolic sequence and advances to a next level in response to receiving the selection of the first symbolic sequence.

Abstract: A strip dispenser (70) for dispensing one strip (S) from a plurality of strips (S). The strip dispenser (70) includes a container (2) that is constructed and arranged to hold a number of strips (S). There is a first structure (3) that defines one or more thin slots (8) that are generally parallel to the perimeter of the container (2), and that have a smallest dimension that is greater than the smallest dimension of a strip (S), where the slots (8) are configured and arranged to inhibit two strips that are stuck together back to back from passing through the slot (8) together. There is also a strip sorting structure (4) that inhibits a strip (S) that has at least partially passed through a slot (8) from fully leaving the container (2) until the strip (S) is pulled out of the container (2) by the user.

Abstract: A dispensing apparatus includes a container having an opening, and a doser coupled with the container about the container opening. The doser includes a housing forming a chamber with an interior wall, an inlet, and an outlet. The inlet is diametrically offset from the outlet, and substantially aligned with the opening of the container. The doser also includes a covering member to alternatively cover and open the inlet and the outlet. The covering member is movable about a range of positions to substantially completely cover at least one of the inlet and outlet at all positions in the range. The covering member covers no more than a portion of the chamber interior wall when the covering member completely opens the outlet.

Abstract: Disclosed herein is a hydraulic tool user interface. The hydraulic tool user interface includes a rocker section, a drain trigger section, and an activation trigger section. The rocker section includes a first end, a second end, and a first contact portion. The first contact portion is between the first end and the second end. The first contact portion is configured to contact a drain pin. The drain trigger section is at the first end. The activation trigger section is between the first end and the second end. The activation trigger section is configured to contact the second end. The activation trigger section is configured to contact an electrical switch.

Abstract: Disclosed herein is a hydraulic tool user interface. The hydraulic tool user interface includes a rocker section, a drain trigger section, and an activation trigger section. The rocker section includes a first end, a second end, and a first contact portion. The first contact portion is between the first end and the second end. The first contact portion is configured to contact a drain pin. The drain trigger section is at the first end. The activation trigger section is between the first end and the second end. The activation trigger section is configured to contact the second end. The activation trigger section is configured to contact an electrical switch.

Abstract: Disclosed herein is a hydraulic tool user interface. The hydraulic tool user interface includes a rocker section, a drain trigger section, and an activation trigger section. The rocker section includes a first end, a second end, and a first contact portion. The first contact portion is between the first end and the second end. The first contact portion is configured to contact a drain pin. The drain trigger section is at the first end. The activation trigger section is between the first end and the second end. The activation trigger section is configured to contact the second end. The activation trigger section is configured to contact an electrical switch.

Abstract: An injection device for use with a pre-filled syringe. The device features a track and track follower engagement which facilitates locking a protective needle guard over the tip of the needle at the conclusion of the injection. The device further includes a tamper evidence overcap which, once removed from the device cannot be readily reinstalled. The injection device features a tubular handle which is grasped by the hand and moved towards the injection site to administer the injection. The device is suitable for self-administration of injections. Use of the device is not technique dependent. Its design, including tubular handle which is grasped in one hand, is easy to use even by the elderly and persons with limited dexterity.