Patents by Inventor Nathan S. Bryan

Nathan S. Bryan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR PROMOTING NITRIC OXIDE PRODUCTION THROUGH AN ORAL DELIVERY SYSTEM
    Publication number: 20240100102
    Abstract: Probiotic compositions, particularly oral compositions, comprising one or more bacteria that are capable of producing nitrite and/or nitric oxide in a subject are provided. Some compositions further comprise nitrate/nitrate, such as a botanical source of nitrate. Some compositions further comprise botanical sources of nitrate reductase. Also, provided are methods of improving the oral and/or vascular health of a subject by orally administering a composition comprising one or more bacteria capable of producing nitric oxide. Methods of repopulating the nitric oxide producing microflora and bacterial environment in the oral cavity of a subject are also provided.
    Type: Application
    Filed: November 30, 2023
    Publication date: March 28, 2024
    Inventor: Nathan S. BRYAN
  • COMPOSITIONS AND METHODS FOR PROMOTING NITRIC OXIDE PRODUCTION THROUGH AN ORAL DELIVERY SYSTEM
    Publication number: 20230310520
    Abstract: Probiotic compositions, particularly oral compositions, comprising one or more bacteria that are capable of producing nitrite and/or nitric oxide in a subject are provided. Some compositions further comprise nitrate/nitrate, such as a botanical source of nitrate. Some compositions further comprise botanical sources of nitrate reductase. Also, provided are methods of improving the oral and/or vascular health of a subject by orally administering a composition comprising one or more bacteria capable of producing nitric oxide. Methods of repopulating the nitric oxide producing microflora and bacterial environment in the oral cavity of a subject are also provided.
    Type: Application
    Filed: April 20, 2023
    Publication date: October 5, 2023
    Inventor: Nathan S. BRYAN
  • COMPOSITIONS AND METHODS FOR PROMOTING NITRIC OXIDE PRODUCTION THROUGH AN ORAL DELIVERY SYSTEM
    Publication number: 20220160792
    Abstract: Probiotic compositions, particularly oral compositions, comprising one or more bacteria that are capable of producing nitrite and/or nitric oxide in a subject are provided. Some compositions further comprise nitrate/nitrate, such as a botanical source of nitrate. Some compositions further comprise botanical sources of nitrate reductase. Also, provided are methods of improving the oral and/or vascular health of a subject by orally administering a composition comprising one or more bacteria capable of producing nitric oxide. Methods of repopulating the nitric oxide producing microflora and bacterial environment in the oral cavity of a subject are also provided.
    Type: Application
    Filed: February 14, 2022
    Publication date: May 26, 2022
    Inventor: Nathan S. Bryan
  • NITRITE FORMULATIONS AND THEIR USE AS NITRIC OXIDE PRODRUGS
    Publication number: 20210290663
    Abstract: Compositions comprising from about 40 weight parts to about 1000 weight parts of a botanical nitrate source; from about 20 weight parts to about 500 weight parts of a botanical source of nitrite reduction activity; and from about 4 weight parts to about 100 weight parts of a nitrite salt. Use of said composition in methods of reducing triglycerides or reducing C-reactive protein levels are also provided.
    Type: Application
    Filed: June 1, 2021
    Publication date: September 23, 2021
    Inventors: Nathan S. Bryan, Janet Zand
  • METHOD OF PRODUCING PHYSIOLOGICAL AND THERAPEUTIC LEVELS OF NITRIC OXIDE THROUGH AN ORAL DELIVERY SYSTEM
    Publication number: 20210023126
    Abstract: A composition and method of providing nitric oxide and nitrite therapy to patients whereby a therapeutic amount is bioavailable within approximately 30 minutes of administration. In embodiments of the invention, nitric oxide is produced in the oral cavity.
    Type: Application
    Filed: October 14, 2020
    Publication date: January 28, 2021
    Inventors: Nathan S. Bryan, Jose G. Rocca
  • NITRITE FORMULATIONS AND THEIR USE AS NITRIC OXIDE PRODRUGS
    Publication number: 20200237808
    Abstract: Compositions comprising from about 40 weight parts to about 1000 weight parts of a botanical nitrate source; from about 20 weight parts to about 500 weight parts of a botanical source of nitrite reduction activity; and from about 4 weight parts to about 100 weight parts of a nitrite salt. Use of said composition in methods of reducing triglycerides or reducing C-reactive protein levels are also provided.
    Type: Application
    Filed: April 7, 2020
    Publication date: July 30, 2020
    Inventors: Nathan S. Bryan, Janet Zand
  • COMPOSITIONS AND METHODS FOR PROMOTING NITRIC OXIDE PRODUCTION THROUGH AN ORAL DELIVERY SYSTEM
    Publication number: 20200038458
    Abstract: Probiotic compositions, particularly oral compositions, comprising one or more bacteria that are capable of producing nitrite and/or nitric oxide in a subject are provided. Some compositions further comprise nitrate/nitrate, such as a botanical source of nitrate. Some compositions further comprise botanical sources of nitrate reductase. Also, provided are methods of improving the oral and/or vascular health of a subject by orally administering a composition comprising one or more bacteria capable of producing nitric oxide. Methods of repopulating the nitric oxide producing microflora and bacterial environment in the oral cavity of a subject are also provided.
    Type: Application
    Filed: October 10, 2019
    Publication date: February 6, 2020
    Inventor: Nathan S. Bryan
  • Compositions and methods for promoting nitric oxide production through an oral delivery system
    Patent number: 10471109
    Abstract: Probiotic compositions, particularly oral compositions, comprising one or more bacteria that are capable of producing nitrite and/or nitric oxide in a subject are provided. Some compositions further comprise nitrate/nitrate, such as a botanical source of nitrate. Some compositions further comprise botanical sources of nitrate reductase. Also, provided are methods of improving the oral and/or vascular health of a subject by orally administering a composition comprising one or more bacteria capable of producing nitric oxide. Methods of repopulating the nitric oxide producing microflora and bacterial environment in the oral cavity of a subject are also provided.
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: November 12, 2019
    Assignee: The Board of Regents of The University of Texas System
    Inventor: Nathan S. Bryan
  • METHOD OF PRODUCING PHYSIOLOGICAL AND THERAPEUTIC LEVELS OF NITRIC OXIDE THROUGH AN ORAL DELIVERY SYSTEM
    Publication number: 20190314404
    Abstract: A composition and method of providing nitric oxide and nitrite therapy to patients whereby a therapeutic amount is bioavailable within approximately 30 minutes of administration. In embodiments of the invention, nitric oxide is produced in the oral cavity.
    Type: Application
    Filed: May 29, 2019
    Publication date: October 17, 2019
    Inventors: Nathan S. Bryan, Jose G. Rocca
  • Method of producing physiological and therapeutic levels of nitric oxide through an oral delivery system
    Patent number: 10342822
    Abstract: A composition and method of providing nitric oxide and nitrite therapy to patients whereby a therapeutic amount is bioavailable within approximately 30 minutes of administration. In embodiments of the invention, nitric oxide is produced in the oral cavity.
    Type: Grant
    Filed: October 19, 2017
    Date of Patent: July 9, 2019
    Assignees: Board of Regents of the University of Texas System, Neogenis Labs, Inc.
    Inventors: Nathan S. Bryan, Jose G. Rocca
  • NITRITE FORMULATIONS AND THEIR USE AS NITRIC OXIDE PRODRUGS
    Publication number: 20190083528
    Abstract: Compositions comprising from about 40 weight parts to about 1000 weight parts of a botanical nitrate source; from about 20 weight parts to about 500 weight parts of a botanical source of nitrite reduction activity; and from about 4 weight parts to about 100 weight parts of a nitrite salt. Use of said composition in methods of reducing triglycerides or reducing C-reactive protein levels are also provided.
    Type: Application
    Filed: October 2, 2018
    Publication date: March 21, 2019
    Inventors: Nathan S. Bryan, Janet Zand
  • METHOD OF PRODUCING PHYSIOLOGICAL AND THERAPEUTIC LEVELS OF NITRIC OXIDE THROUGH AN ORAL DELIVERY SYSTEM
    Publication number: 20180153929
    Abstract: A composition and method of providing nitric oxide and nitrite therapy to patients whereby a therapeutic amount is bioavailable within approximately 30 minutes of administration. In embodiments of the invention, nitric oxide is produced in the oral cavity.
    Type: Application
    Filed: October 19, 2017
    Publication date: June 7, 2018
    Inventors: Nathan S. Bryan, Jose G. Rocca
  • Method of producing physiological and therapeutic levels of nitric oxide through an oral delivery system
    Patent number: 9821006
    Abstract: A composition and method of providing nitric oxide and nitrite therapy to patients whereby a therapeutic amount is bioavailable within approximately 30 minutes of administration. In embodiments of the invention, nitric oxide is produced in the oral cavity.
    Type: Grant
    Filed: January 6, 2016
    Date of Patent: November 21, 2017
    Assignees: Board of Regents of the University of Texas System, Neogenis Labs, Inc.
    Inventors: Nathan S. Bryan, Jose G. Rocca
  • METHOD OF PRODUCING PHYSIOLOGICAL AND THERAPEUTIC LEVELS OF NITRIC OXIDE THROUGH AN ORAL DELIVERY SYSTEM
    Publication number: 20160287628
    Abstract: A composition and method of providing nitric oxide and nitrite therapy to patients whereby a therapeutic amount is bioavailable within approximately 30 minutes of administration. In embodiments of the invention, nitric oxide is produced in the oral cavity.
    Type: Application
    Filed: January 6, 2016
    Publication date: October 6, 2016
    Inventors: Nathan S. Bryan, Jose G. Rocca
  • COMPOSITIONS AND METHODS FOR PROMOTING NITRIC OXIDE PRODUCTION THROUGH AN ORAL DELIVERY SYSTEM
    Publication number: 20160151428
    Abstract: Probiotic compositions, particularly oral compositions, comprising one or more bacteria that are capable of producing nitrite and/or nitric oxide in a subject are provided. Some compositions further comprise nitrate/nitrate, such as a botanical source of nitrate. Some compositions further comprise botanical sources of nitrate reductase. Also, provided are methods of improving the oral and/or vascular health of a subject by orally administering a composition comprising one or more bacteria capable of producing nitric oxide. Methods of repopulating the nitric oxide producing microflora and bacterial environment in the oral cavity of a subject are also provided.
    Type: Application
    Filed: May 5, 2014
    Publication date: June 2, 2016
    Inventor: Nathan S. BRYAN
  • NITRITE FORMULATIONS AND THEIR USE AS NITRIC OXIDE PRODRUGS
    Publication number: 20160038533
    Abstract: Compositions comprising from about 40 weight parts to about 1000 weight parts of a botanical nitrate source; from about 20 weight parts to about 500 weight parts of a botanical source of nitrite reduction activity; and from about 4 weight parts to about 100 weight parts of a nitrite salt. Use of said composition in methods of reducing triglycerides or reducing C-reactive protein levels are also provided.
    Type: Application
    Filed: August 14, 2015
    Publication date: February 11, 2016
    Inventors: Nathan S. Bryan, Janet Zand
  • Method of producing physiological and therapeutic levels of nitric oxide through an oral delivery system
    Patent number: 9241999
    Abstract: A composition and method of providing nitric oxide and nitrite therapy to patients whereby a therapeutic amount is bioavailable within approximately 30 minutes of administration. In embodiments of the invention, nitric oxide is produced in the oral cavity.
    Type: Grant
    Filed: August 17, 2012
    Date of Patent: January 26, 2016
    Assignees: Board of Regents of the University of Texas System, Neogenis Labs, Inc.
    Inventors: Nathan S. Bryan, Jose G. Rocca
  • Nitrite formulations and their use as nitric oxide prodrugs
    Patent number: 9119823
    Abstract: Compositions comprising from about 40 weight parts to about 1000 weight parts of a botanical nitrate source; from about 20 weight parts to about 500 weight parts of a botanical source of nitrite reduction activity; and from about 4 weight parts to about 100 weight parts of a nitrite salt. Use of said composition in methods of reducing triglycerides or reducing C-reactive protein levels are also provided.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: September 1, 2015
    Assignees: Board of Regents, The University of Texas System, Neogenis Labs, Inc.
    Inventors: Nathan S. Bryan, Janet Zand
  • NITRITE FORMULATIONS AND THEIR USE AS NITRIC OXIDE PRODRUGS
    Publication number: 20150164839
    Abstract: Compositions comprising from about 40 weight parts to about 1000 weight parts of a botanical nitrate source; from about 20 weight parts to about 500 weight parts of a botanical source of nitrite reduction activity; and from about 4 weight parts to about 100 weight parts of a nitrite salt. Use of said composition in methods of reducing triglycerides or reducing C-reactive protein levels are also provided.
    Type: Application
    Filed: January 30, 2015
    Publication date: June 18, 2015
    Inventors: Nathan S. Bryan, Janet Zand
  • Nitrite formulations and their use as nitric oxide prodrugs
    Patent number: 8962038
    Abstract: Compositions comprising from about 40 weight parts to about 1000 weight parts of a botanical nitrate source; from about 20 weight parts to about 500 weight parts of a botanical source of nitrite reduction activity; and from about 4 weight parts to about 100 weight parts of a nitrite salt. Use of the composition in methods of reducing triglycerides or reducing C-reactive protein levels are also provided.
    Type: Grant
    Filed: November 5, 2012
    Date of Patent: February 24, 2015
    Assignees: Board of Regents, The University of Texas System, Neogenis Labs, Inc.
    Inventors: Nathan S. Bryan, Janet Zand