Patents by Inventor Nathan Shapiro

Nathan Shapiro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11774444
    Abstract: Methods and apparatus for detecting cell-bound and soluble antigens in a biological sample are described. The method comprises forming complexes of at least one antibody-coated bead and at least one antigen in a solution, placing the solution in a magnetic field such that the formed complexes levitate in the solution at a particular height, and determining at least one characteristic of the antigen in the complexes based, at least in part, on an image of the complexes showing the magnetic levitation height.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: October 3, 2023
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Ionita C. Ghiran, Nathan Shapiro, Anish V. Sharda, Edward J. Felton
  • Publication number: 20230027055
    Abstract: The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.
    Type: Application
    Filed: April 7, 2021
    Publication date: January 26, 2023
    Inventors: Elizabeth M. Bacon, Elbert Chin, Jeromy J. Cottell, Ashley Anne Katana, Darryl Kato, John O. Link, Nathan Shapiro, Teresa Alejandra Trejo Martin, Zheng-Yu Yang
  • Patent number: 11078208
    Abstract: The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.
    Type: Grant
    Filed: March 2, 2020
    Date of Patent: August 3, 2021
    Assignee: Gilead Sciences, Inc.
    Inventors: Elizabeth M. Bacon, Elbert Chin, Jeromy J. Cottell, Ashley Anne Katana, Darryl Kato, John O. Link, Nathan Shapiro, Teresa Alejandra Trejo Martin, Zheng-Yu Yang
  • Patent number: 11052087
    Abstract: The invention provides compounds having Formula (I): or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising the same, processes for their preparation, and methods of treating and preventing HIV infection by their administration.
    Type: Grant
    Filed: July 29, 2019
    Date of Patent: July 6, 2021
    Assignee: Gilead Sciences, Inc.
    Inventors: Elbert Chin, Darryl Kato, John O. Link, Nathan Shapiro, Zheng-Yu Yang
  • Patent number: 10752636
    Abstract: The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: August 25, 2020
    Assignee: Gilead Sciences, Inc.
    Inventors: Elizabeth M. Bacon, Elbert Chin, Jeromy J. Cottell, Ashley Anne Katana, Darryl Kato, John O. Link, Nathan Shapiro, Teresa Alejandra Trejo Martin, Zheng-Yu Yang
  • Publication number: 20200030327
    Abstract: The invention provides compounds having Formula (I): or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising the same, processes for their preparation, and methods of treating and preventing HIV infection by their administration.
    Type: Application
    Filed: July 29, 2019
    Publication date: January 30, 2020
    Applicant: Gilead Sciences, Inc.
    Inventors: Elbert Chin, Darryl Kato, John O. Link, Nathan Shapiro, Zheng-Yu Yang
  • Patent number: 10442804
    Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions which may be used in methods of treating a hepatitis B virus infection.
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: October 15, 2019
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Evangelos Aktoudianakis, Eda Canales, Kevin S. Currie, Darryl Kato, Jiayao Li, John O. Link, Samuel E. Metobo, Roland D. Saito, Scott D. Schroeder, Nathan Shapiro, Winston C. Tse, Qiaoyin Wu, Yunfeng Eric Hu
  • Publication number: 20190308983
    Abstract: The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herin. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.
    Type: Application
    Filed: March 26, 2019
    Publication date: October 10, 2019
    Inventors: Elizabeth M. Bacon, Elbert Chin, Jeromy J. Cottell, Ashley Anne Katana, Darryl Kato, John O. Link, Nathan Shapiro, Teresa Alejandra Trejo Martin, Zheng-Yu Yang
  • Publication number: 20190293639
    Abstract: Methods and apparatus for detecting cell-bound and soluble antigens in a biological sample are described. The method comprises forming complexes of at least one antibody-coated bead and at least one antigen in a solution, placing the solution in a magnetic field such that the formed complexes levitate in the solution at a particular height, and determining at least one characteristic of the antigen in the complexes based, at least in part, on an image of the complexes showing the magnetic levitation height.
    Type: Application
    Filed: November 10, 2017
    Publication date: September 26, 2019
    Applicant: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Ionita C. Ghiran, Nathan Shapiro, Anish V. Sharda, Edward J. Felton
  • Patent number: 10294234
    Abstract: The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: May 21, 2019
    Assignee: Gilead Sciences, Inc.
    Inventors: Elizabeth M. Bacon, Elbert Chin, Jeromy J. Cottell, Ashley Anne Katana, Darryl Kato, John O. Link, Nathan Shapiro, Teresa Alejandra Trejo Martin, Zheng-Yu Yang
  • Publication number: 20180258097
    Abstract: The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.
    Type: Application
    Filed: February 5, 2018
    Publication date: September 13, 2018
    Inventors: Elizabeth M. Bacon, Elbert Chin, Jeromy J. Cottell, Ashley Anne Katana, Darryl Kato, John O. Link, Nathan Shapiro, Teresa Alejandra Trejo Martin, Zheng-Yu Yang
  • Publication number: 20180251460
    Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions which may be used in methods of treating a hepatitis B virus infection.
    Type: Application
    Filed: January 31, 2018
    Publication date: September 6, 2018
    Inventors: Evangelos Aktoudianakis, Eda Canales, Kevin S. Currie, Darryl Kato, Jiayao Li, John O. Link, Samuel E. Metobo, Roland D. Saito, Scott D. Schroeder, Nathan Shapiro, Winston C. Tse, Qiaoyin Wu
  • Patent number: 10030033
    Abstract: The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: July 24, 2018
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Amy Cagulada, Johann Chan, Lina Chan, Denise A. Colby, Kapil Kumar Karki, Darryl Kato, Katie Ann Keaton, Sudha Kondappally, Chris Levins, Adam Littke, Ruben Martinez, Dominika Pcion, Troy Reynolds, Bruce Ross, Michael Sangi, Adam J. Schrier, Pamela Seng, Dustin Siegel, Nathan Shapiro, Donald Tang, James G. Taylor, Jonathan Tripp, Andrew W. Waltman, Lawrence Yu
  • Publication number: 20170210756
    Abstract: The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.
    Type: Application
    Filed: August 3, 2016
    Publication date: July 27, 2017
    Inventors: Amy Cagulada, Johann Chan, Lina Chan, Denise A. Colby, Kapil Kumar Karki, Darryl Kato, Katie Ann Keaton, Sudha Kondapally, Christopher Levins, Adam Littke, Ruben Martinez, Dominika Pcion, Troy Reynolds, Bruce Ross, Michael Sangi, Adam J. Schrier, Pamela Seng, Dustin Siegel, Nathan Shapiro, Donald Tang, James G. Taylor, Jonathan Tripp, Andrew W. Waltman, Lawrence Yu
  • Publication number: 20170126886
    Abstract: Calling parties are provided a system which supplants and replaces their on hold phone signal sent by the phone call receiving party. The on hold signal is monitored and controlled. During the holding time the calling party is allowed to use their own phone to pursue other tasks. Upon its termination the calling party is returned to the phone call.
    Type: Application
    Filed: October 17, 2016
    Publication date: May 4, 2017
    Applicant: MusicRogue
    Inventors: Joel Nathan Shapiro, Jason Wells Davies
  • Patent number: 9440991
    Abstract: The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: September 13, 2016
    Assignee: Gilead Sciences, Inc.
    Inventors: Amy Cagulada, Johann Chan, Lina Chan, Denise A. Colby, Kapil Kumar Karki, Darryl Kato, Katie Ann Keaton, Sudha Kondapally, Chris Levins, Adam Littke, Ruben Martinez, Dominika Pcion, Troy Reynolds, Bruce Ross, Michael Sangi, Adam J. Schrier, Pamela Seng, Dustin Siegel, Nathan Shapiro, Donald Tang, James G. Taylor, Jonathan Tripp, Andrew W. Waltman, Lawrence Yu
  • Publication number: 20150175626
    Abstract: The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.
    Type: Application
    Filed: December 18, 2014
    Publication date: June 25, 2015
    Applicant: GILEAD SCIENCES, INC.
    Inventors: Amy Cagulada, Johann Chan, Lina Chan, Denise A. Colby, Kapil Kumar Karki, Darryl Kato, Katie Ann Keaton, Sudha Kondapally, Chris Levins, Adam Littke, Ruben Martinez, Dominika Pcion, Troy Reynolds, Bruce Ross, Michael Sangi, Adam J. Schrier, Pamela Seng, Dustin Siegel, Nathan Shapiro, Donald Tang, James G. Taylor, Jonathan Tripp, Andrew W. Waltman, Lawrence Yu
  • Patent number: 7975384
    Abstract: Apparatus/systems and methods are disclosed for facilitating installation of conduit systems through construction openings. Exemplary embodiments enable one to form, maintain, and controllably block the openings and incorporate the apparatus/systems into the finished construction. Exemplary apparatus/systems disclosed include (i) a structural member that includes one or more side walls defining an opening, one or more base flaps, and one or more top flaps, and (ii) at least one cover to controllably block said opening. Exemplary methods disclosed include (i) installing said apparatus/system that includes (1) securing the structural member relative to a deck, and (2) introducing cement/concrete relative to structural member covering the base flaps and fixing the structural member with respect to the deck, and (ii) installing a conduit system through an apparatus/system-defined opening that includes encasing the cover(s) together with the installed conduit system.
    Type: Grant
    Filed: July 20, 2007
    Date of Patent: July 12, 2011
    Inventor: Nathan Shapiro
  • Publication number: 20090019699
    Abstract: Apparatus/systems and methods are disclosed for facilitating installation of conduit systems through construction openings. Exemplary embodiments enable one to form, maintain, and controllably block the openings and incorporate the apparatus/systems into the finished construction. Exemplary apparatus/systems disclosed include (i) a structural member that includes one or more side walls defining an opening, one or more base flaps, and one or more top flaps, and (ii) at least one cover to controllably block said opening. Exemplary methods disclosed include (i) installing said apparatus/system that includes (1) securing the structural member relative to a deck, and (2) introducing cement/concrete relative to structural member covering the base flaps and fixing the structural member with respect to the deck, and (ii) installing a conduit system through an apparatus/system-defined opening that includes encasing the cover(s) together with the installed conduit system.
    Type: Application
    Filed: July 20, 2007
    Publication date: January 22, 2009
    Inventor: Nathan Shapiro