Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein.

Abstract: The devices and systems can allow for safe and cost-effective administration intravenous medication, for example, in psychiatric settings by mitigating ligature, disassembly, and weaponization risks associated with intravenous administration. The system may include a fluid connection device. The fluid connection device may include an internal conduit configured to deliver a medical fluid and a housing disposed in which the internal conduit is disposed. The housing may include a first rigid segment and a second rigid segment spaced from the first rigid segment. The housing may also include a first joint segment disposed between the first rigid segment and the second rigid segment and configured to bend to the predetermined bending angle with respect to the first rigid segment.

Abstract: A drone pod may receive, stow, and launch a drone. The drone pod may include a housing, a canopy movably coupled to the housing, a platform movably coupled to the housing, and a drone bay. The drone pod may be configured to move the canopy to expose the drone bay and raise the platform relative to a floor of the drone bay to receive the drone, lower the platform toward the floor of the drone bay and move the canopy to enclose the drone bay to stow the drone, move the canopy to expose the drone bay and raise the platform relative to the floor of the drone bay to launch the drone. The drone pod may be mounted on a vehicle. A system may include a drone pod and a drone, wherein the drone pod is configured to receive, stow, and launch the drone.

Abstract: Methods and related systems for charging a refrigerant into a climate control system. In an embodiment, the method includes (a) coupling a storage tank to a refrigerant loop of the climate control system through a charging valve; (b) opening and closing the charging valve in a plurality of cycles; and (c) flowing refrigerant from the storage tank to the refrigerant loop through the charging valve when the charging valve is open, during (b). In addition, the method includes (d) determining a detected saturated temperature of the refrigerant within the refrigerant loop after each cycle of the plurality of cycles; and (e) adjusting an amount of time that the charging valve is open during each cycle of the plurality of cycles during (b) as a function of the detected saturated temperature from a previous cycle of the plurality of cycles.

Abstract: A gaming system includes a processor and a memory storing instructions and a persistence counter. The instructions cause the processor to cause display of an initial game outcome by displaying symbols from a plurality of reels in a plurality of columns, the plurality of reels including a plurality of symbol types and increment the persistence counter based on the initial game outcome. The instructions further cause the processor to determine, based on a value of the persistence counter, at least one symbol type of the plurality of symbol types, change the at least one symbol type in the initial game outcome to a second symbol type, and determine, based on changing the at least one symbol type, an upgraded game outcome.

Abstract: Methods and related systems for controlling an indoor air temperature for a heat pump system are disclosed. The method includes (a) determining an outdoor coil temperature of an outdoor heat exchanger and a speed of a compressor of a heat pump system, (b) determining a target indoor coil temperature of the indoor coil based on the outdoor coil temperature and the speed of the compressor, and (c) adjusting a speed of air flowing across the indoor coil based on a difference between a current indoor coil temperature and the target indoor coil temperature to reduce the difference between the current indoor coil temperature and the target indoor coil temperature.

Abstract: An electronic gaming system including a memory and a processor is described. The processor is configured to cause display of a first display area including a plurality of symbol positions for an electronic game, determine a respective symbol for each symbol position of the plurality of symbol positions, and cause at least one bonus symbol to advance at least one symbol position of the plurality of symbol positions toward an edge of the plurality of symbol positions. The processor is also configured to cause display of at least a portion of the at least one bonus symbol in a second display area wherein display of at least the portion of the at least one bonus symbol indicates that an output amount will be provided and cause the output amount associated with the at least one bonus symbol to be provided.

Abstract: Methods and related systems for controlling indoor relative humidity include (a) determining a target dew point temperature based on desired indoor conditions for the indoor space, and (b) determining an initial dew point temperature based on an initial set of current indoor conditions of the indoor space. The method includes (c) determining a target coil temperature of a coil of an indoor heat exchanger of the climate control system based on the target dew point temperature and the initial dew point temperature, and (d) adjusting a speed of air flowing across the coil or a speed of a compressor of the climate control system after (c) based on the target coil temperature to reduce a difference between a coil temperature of the coil and the target coil temperature.

Abstract: Electronic gaming machines and systems are disclosed that provide for a symbol-based main game that features an array of symbol positions that may if an array growth condition is met, increase in size. Determining whether the array growth condition is met may involve determining how many array growth symbols are shown in association with a game play. A further determination may be made as to whether a feature game trigger condition is met and, if so, a feature game may be presented that utilizes the same array of symbol positions that were present in the main game when the feature game was triggered. Additional array growth may occur in the feature game if the array growth condition is met again.

Abstract: A washing machine appliance and methods of operating a washing machine appliance are provided. The washing machine appliance includes a motor and a rotatable basket. The motor is operated to rotate the basket. While operating the motor to rotate the basket, a power consumption and a balance condition of a load of articles in the basket are determined. A size of the load of articles in the basket of the washing machine appliance is determined based on the power consumption and the balance condition. Based on the determined size of the load, one or more operating parameters of the washing machine appliance are selected and an operation of the washing machine appliance is performed according to the one or more selected operating parameters.

Abstract: A graphical user interface for providing a game of chance with upgradeable feature symbols and meters reflecting progress towards satisfaction of goals that cause such a feature symbol upgrade.

Abstract: Techniques for discovering primary, unique, and/or foreign keys for relational datasets are described. The techniques include profiling the relational datasets to obtain respective data profiles; identifying one or more primary key candidates for a first relational dataset using a first data profile of the first relational dataset and a first trained machine learning model; identifying one or more foreign key proposals for a second relational dataset using the one or more primary key candidates by performing a subset analysis of the second relational dataset with respect to the first relational dataset; identifying one or more foreign key candidates for the second relational dataset using the first data profile, a second data profile of the second relational dataset, and a second trained machine learning model different from the first trained machine learning model; and outputting the at primary key candidate(s) and the foreign key candidate(s).

Abstract: Techniques and systems for providing games of chance with multiple levels of persistent features are disclosed. Some example systems include scatter prize indicators that are each associated with different symbol positions of a game of chance. When a scatter symbol is selected for a given symbol position, the scatter prize indicator associated therewith may be upgraded; selection of a sufficient number of symbol positions may result in a feature game mode being activated. During feature game mode play, scatter symbols are retained after each play of the game until either sufficient consecutive plays occur without any scatter symbols being obtained or until all symbol positions have scatter symbols. In the latter case, the scatter prize indicators are upgraded and play continues. In the former case, the feature game mode concludes. Various enhancements may be triggered based on the number of times that the feature game mode has been activated.

Abstract: An elastic bladder that is filled with water. The water adds weight to the line for casting, allowing a lure to be cast farther. The bladder has an arrangement of tubes that are inserted into each other. One long rigid tube has a folding hinge at the base. A leader is secured to the bladder with a bridle. The remainder of the leader can be coiled and attached in the “v” of a lower valve that retains the water in the bladder. This coiling allows the bladder to be positioned far above the hook, allowing the hook to be placed deeper than when using an ordinary float. After casting, the hinge is released, and the bladder empties, becoming a float.

Abstract: Methods and systems for shifting a transmission of an electric vehicle are described. The methods and systems may be applied to fully electric or hybrid vehicles. The methods and systems may allow a transmission to be shifted within an acceptable time frame without supplying excess charge to an electric energy storage device.

Abstract: A nuclear reactor is constructed in sub-modules and super modules which are manufactured, packaged, and shipped to a construction site. At least some of the modules are packaged in suitable shielding containers or portions of containers, which may be steel. The modules are assembled on-site, and some of the modules remain within their respective shipping containers after assembly. One or more of the shipping containers may be used as concrete forms to support the pouring of concrete in between selected modules. The concrete may be used for structural support, shielding, or both.

Abstract: An in-vessel fuel transfer machine may be permanently affixed to a nuclear reactor and remain in place during power operations. The in-vessel fuel transfer machine may include a pantograph machine that positions a grapple in order to access any fuel socket location within the core and move any of the core assemblies between the core, an in-vessel fuel storage area, and a fuel elevator. The grapple may be positioned through a combination of movements, such as, rotating a rotating plug assembly, rotating the in-vessel fuel transfer machine, extending the pantograph arms, and shuttling the grapple along a leg. The grapple may be compliant to accommodate deformed core assemblies and may be configured to pivot to more closely align to an eccentric core assembly handling socket or be moveable in a horizontal plane to accommodate a deformed core assembly during insertion or withdrawal.

Abstract: Methods, apparatus, and systems for performing an ophthalmic diagnostic test are disclosed. In one aspect, a head-wearable device for administering an ophthalmic test to a subject can comprise a head-wearable frame for mounting the device onto the subject's head, and a light seal configured for coupling to the frame so as to isolate at least one eye of the subject from ambient light when the device is worn by the subject.

Abstract: A system for providing network services is provided. The system includes a device configured to interface with the network to receive a container, where the container is configured to interface with an operating system of the device and a plurality of applications operating on the device. The container is further configured to interface with a network services provider of one or more network services and one or more third party service providers.