Patents by Inventor Nathan Stasko

Nathan Stasko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210138259
    Abstract: Methods and related devices for impinging light on tissue, for example within a body of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, stimulating enzymatic generation of nitric oxide to increase endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores of nitric oxide, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices and methods for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and targeted tissues with increased efficacy and reduced cytotoxicity.
    Type: Application
    Filed: January 13, 2021
    Publication date: May 13, 2021
    Inventors: Nathan Stasko, David T. Emerson, Adam Cockrell, F. Neal Hunter, Michael John Bergmann, Rebecca McDonald, Nicholas William Medendorp, JR., Gerald H. Negley, Katelyn P. Reighard
  • Publication number: 20210137810
    Abstract: The present invention relates generally to compositions and methods of using the same such as, for example, methods of treating the skin of a subject using a composition as described herein. The composition may comprise a diluent, a solvent, a penetration enhancing agent, a skin brightening agent, a skin renewing agent, a thickening agent, an anti-irritant, a chelating agent, an active pharmaceutical ingredient (API), optionally a pH adjustment agent, and optionally a preservative. The composition may further comprise L-arginine and/or L-citrulline and/or esters and/or derivatives thereof.
    Type: Application
    Filed: June 19, 2018
    Publication date: May 13, 2021
    Inventors: Nathan Stasko, Ryan Doxey
  • Publication number: 20210128938
    Abstract: Methods and related devices for impinging light on tissue, for example within a body of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, stimulating enzymatic generation of nitric oxide to increase endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores of nitric oxide, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices and methods for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and targeted tissues with increased efficacy and reduced cytotoxicity.
    Type: Application
    Filed: January 13, 2021
    Publication date: May 6, 2021
    Inventors: Nathan Stasko, David T. Emerson, Adam Cockrell, F. Neal Hunter, Michael John Bergmann, Rebecca McDonald, Nicholas William Medendorp, JR., Gerald H. Negley, Katelyn P. Reighard
  • Publication number: 20210128936
    Abstract: Methods and related devices for impinging light on tissue, for example within a body of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, stimulating enzymatic generation of nitric oxide to increase endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores of nitric oxide, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices and methods for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and targeted tissues with increased efficacy and reduced cytotoxicity.
    Type: Application
    Filed: January 13, 2021
    Publication date: May 6, 2021
    Inventors: Nathan Stasko, David T. Emerson, Adam Cockrell, F. Neal Hunter, Michael John Bergmann, Rebecca McDonald, Nicholas William Medendorp, JR., Gerald H. Negley, Katelyn P. Reighard
  • Publication number: 20210128937
    Abstract: Methods and related devices for impinging light on tissue, for example within a body of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, stimulating enzymatic generation of nitric oxide to increase endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores of nitric oxide, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices and methods for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and targeted tissues with increased efficacy and reduced cytotoxicity.
    Type: Application
    Filed: January 13, 2021
    Publication date: May 6, 2021
    Inventors: Nathan Stasko, David T. Emerson, Adam Cockrell, F. Neal Hunter, Michael John Bergmann, Rebecca McDonald, Nicholas William Medendorp, JR., Gerald H. Negley, Katelyn P. Reighard
  • Publication number: 20210128935
    Abstract: Methods and related devices for impinging light on tissue, for example within a body of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, stimulating enzymatic generation of nitric oxide to increase endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores of nitric oxide, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices and methods for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and targeted tissues with increased efficacy and reduced cytotoxicity.
    Type: Application
    Filed: December 10, 2020
    Publication date: May 6, 2021
    Inventors: Nathan Stasko, David T. Emerson, Adam Cockrell, F. Neal Hunter, Michael John Bergmann, Rebecca McDonald, Nicholas William Medendorp, JR., Gerald H. Negley, Katelyn P. Reighard
  • Patent number: 10912743
    Abstract: Provided herein are compositions useful for treating inflammation in a subject and methods of decreasing inflammation in the skin, mucosa, and/or eye of a subject comprising applying a pharmaceutical composition that includes an NO-releasing compound to the skin, mucosa, and/or eye of the subject in an amount sufficient to decrease inflammation.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: February 9, 2021
    Assignee: Novan, Inc.
    Inventors: Nathan Stasko, Ryan Doxey, Kimberly McHale, Stanley J. Hollenbach
  • Patent number: 10849864
    Abstract: Provided are combinations comprising terbinafine or a pharmaceutically acceptable salt thereof and a NO source. The combination may be a synergistic combination. Also provided are methods of treating and/or preventing a fungal infection in a subject comprising administering terbinafine or a pharmaceutically acceptable salt thereof to the subject; and administering a NO source to the subject, thereby treating and/or preventing the fungal infection in the subject. The dose of terbinafine or a pharmaceutically acceptable salt thereof and the dose of the NO source administered to the subject may achieve a synergistic effect.
    Type: Grant
    Filed: July 25, 2016
    Date of Patent: December 1, 2020
    Assignee: Novan, Inc.
    Inventors: Kimberly McHale, Nathan Stasko
  • Publication number: 20200298014
    Abstract: Systems and methods for phototherapeutic modulation of nitric oxide in mammalian tissue include use of a first wavelength and first radiant flux of light to stimulate enzymatic generation of nitric oxide, and use of a second wavelength and second radiant flux of light to stimulate release of nitric oxide from endogenous stores of nitric oxide. Pulsed light and/or partially non-overlapping light impingement windows may be used. Non-coherent light impinged on tissue may include a peak wavelength in a range of from 410 nm to 440 nm in the absence of light emissions having a peak wavelength of from 600 nm to 900 nm.
    Type: Application
    Filed: June 10, 2020
    Publication date: September 24, 2020
    Inventors: Nathan Stasko, Nicholas William Medendorp, JR., Gerald H. Negley, Katelyn P. Reighard
  • Patent number: 10736839
    Abstract: The present invention relates generally to topical antiviral compositions, delivery systems, and methods of using the same.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: August 11, 2020
    Assignee: Novan, Inc.
    Inventors: Kimberly McHale, Ryan Doxey, Nathan Stasko
  • Publication number: 20200230048
    Abstract: The present invention relates generally to topical antiviral compositions, delivery systems, and methods of using the same.
    Type: Application
    Filed: April 6, 2020
    Publication date: July 23, 2020
    Inventors: Kimberly McHale, Ryan Doxey, Nathan Stasko
  • Publication number: 20200222714
    Abstract: Systems and methods for phototherapeutic modulation of nitric oxide in mammalian tissue include use of a first wavelength and first radiant flux of light to stimulate enzymatic generation of nitric oxide, and use of a second wavelength and second radiant flux of light to stimulate release of nitric oxide from endogenous stores of nitric oxide. Pulsed light and/or partially non-overlapping light impingement windows may be used. Non-coherent light impinged on tissue may include a peak wavelength in a range of from 410 nm to 440 nm in the absence of light emissions having a peak wavelength of from 600 nm to 900 nm.
    Type: Application
    Filed: December 10, 2019
    Publication date: July 16, 2020
    Inventors: Nathan Stasko, Nicholas William Medendorp, JR., Gerald H. Negley, Katelyn P. Reighard
  • Publication number: 20200188261
    Abstract: The present invention relates generally to compositions and methods of using the same such as, for example, methods of treating the skin of a subject using a composition as described herein. The composition may comprise a diluent, a surfactant, a thickening agent, a humectant, a cooling agent, a chelating agent, optionally a pH adjustment agent, and optionally a preservative. The composition may further comprise L-arginine and/or L-citrulline and/or esters and/or derivatives thereof.
    Type: Application
    Filed: June 19, 2018
    Publication date: June 18, 2020
    Inventors: Nathan Stasko, Ryan Doxey
  • Publication number: 20200061089
    Abstract: Provided herein are anhydrous compositions that include at least one viscosity increasing agent, at least one organic solvent and at least one humectant. Such compositions may also include at least one active pharmaceutical ingredient (API) and/or at least one water repellant. Related compositions, methods and kits are also provided.
    Type: Application
    Filed: November 4, 2019
    Publication date: February 27, 2020
    Inventors: Ryan Doxey, Nathan Stasko
  • Patent number: 10569097
    Abstract: Systems and methods for phototherapeutic modulation of nitric oxide in mammalian tissue include use of a first wavelength and first radiant flux of light to stimulate enzymatic generation of nitric oxide, and use of a second wavelength and second radiant flux of light to stimulate release of nitric oxide from endogenous stores of nitric oxide. Pulsed light and/or partially non-overlapping light impingement windows may be used. Non-coherent light impinged on tissue may include a peak wavelength in a range of from 410 nm to 440 nm in the absence of light emissions having a peak wavelength of from 600 nm to 900 nm.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: February 25, 2020
    Assignee: PhotonMD, Inc.
    Inventors: Nicholas William Medendorp, Jr., Katelyn P. Reighard, Gerald H. Negley, Nathan Stasko
  • Publication number: 20200055815
    Abstract: Provided here are nitric oxide-releasing compounds that include at least two different NO donor functional groups of the same class. In some embodiments, such nitric oxide-releasing compounds are macromolecules such as dendrimer and co-condensed silica. Pharmaceutical compositions, wound dressings, kits and methods of treatments are also provided herein.
    Type: Application
    Filed: August 29, 2019
    Publication date: February 20, 2020
    Inventors: Mark Schoenfisch, Yuan Lu, Nathan Stasko, Jian Bao
  • Patent number: 10525275
    Abstract: Systems and methods for phototherapeutic modulation of nitric oxide in mammalian tissue include use of a first wavelength and first radiant flux of light to stimulate enzymatic generation of nitric oxide, and use of a second wavelength and second radiant flux of light to stimulate release of nitric oxide from endogenous stores of nitric oxide. Pulsed light and/or partially non-overlapping light impingement windows may be used. Non-coherent light impinged on tissue may include a peak wavelength in a range of from 410 nm to 440 nm in the absence of light emissions having a peak wavelength of from 600 nm to 900 nm.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: January 7, 2020
    Assignee: PhotonMD, Inc.
    Inventors: Nathan Stasko, Nicholas William Medendorp, Jr., Gerald H. Negley, Katelyn P. Reighard
  • Patent number: 10500220
    Abstract: Provided herein are anhydrous compositions that include at least one viscosity increasing agent, at least one organic solvent and at least one humectant. Such compositions may also include at least one active pharmaceutical ingredient (API) and/or at least one water repellant. Related compositions, methods and kits are also provided.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: December 10, 2019
    Assignee: Novan, Inc.
    Inventors: Ryan Doxey, Nathan Stasko
  • Patent number: 10435357
    Abstract: Provided here are nitric oxide-releasing compounds that include at least two different NO donor functional groups of the same class. In some embodiments, such nitric oxide-releasing compounds are macromolecules such as dendrimer and co-condensed silica. Pharmaceutical compositions, wound dressings, kits and methods of treatments are also provided herein.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: October 8, 2019
    Assignees: The University of North Carolina at Chapel Hill, Novan, Inc.
    Inventors: Mark Schoenfisch, Yuan Lu, Nathan Stasko, Jian Bao
  • Publication number: 20190290681
    Abstract: Provided herein are compositions, systems, kits, and methods for treating a viral, bacterial, protozoan, and/or fungal (e.g., onychomycosis and/or tinea pedis) infection.
    Type: Application
    Filed: April 13, 2017
    Publication date: September 26, 2019
    Applicant: Novan, Inc.
    Inventors: Ryan DOXEY, Nathan STASKO, Megan MARTIN