Patents by Inventor Nathan Stasko

Nathan Stasko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180214392
    Abstract: Provided are combinations comprising terbinafine or a pharmaceutically acceptable salt thereof and a NO source. The combination may be a synergistic combination. Also provided are methods of treating and/or preventing a fungal infection in a subject comprising administering terbinafine or a pharmaceutically acceptable salt thereof to the subject; and administering a NO source to the subject, thereby treating and/or preventing the fungal infection in the subject. The dose of terbinafine or a pharmaceutically acceptable salt thereof and the dose of the NO source administered to the subject may achieve a synergistic effect.
    Type: Application
    Filed: July 25, 2016
    Publication date: August 2, 2018
    Inventors: Kimberly McHale, Nathan Stasko
  • Publication number: 20180214598
    Abstract: Provided according to some embodiments of the invention are wound dressings that include a polymer matrix and nitric oxide-releasing polysiloxane macromolecules within and/or on the polymer matrix. Also provided are wound dressing kits and methods of using and forming such wound dressings.
    Type: Application
    Filed: February 2, 2018
    Publication date: August 2, 2018
    Inventors: Nathan Stasko, Susanne Bauman, Pranav R. Joshi
  • Patent number: 9919072
    Abstract: Provided according to some embodiments of the invention are wound dressings that include a polymer matrix and nitric oxide-releasing polysiloxane macromolecules within and/or on the polymer matrix. Also provided are wound dressing kits and methods of using and forming such wound dressings.
    Type: Grant
    Filed: August 20, 2010
    Date of Patent: March 20, 2018
    Assignee: Novan, Inc.
    Inventors: Nathan Stasko, Susanne Bauman, Pranav R. Joshi
  • Publication number: 20180008533
    Abstract: The present invention relates generally to topical antiviral compositions, delivery systems, and methods of using the same.
    Type: Application
    Filed: September 22, 2017
    Publication date: January 11, 2018
    Inventors: Kimberly McHale, Ryan Doxey, Nathan Stasko
  • Patent number: 9855211
    Abstract: The present invention relates generally to topical compositions and methods of using the same.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: January 2, 2018
    Assignee: Novan, Inc.
    Inventors: Ryan Doxey, Adam Sabouni, Eleftherios Kougoulos, Nathan Stasko
  • Publication number: 20170312307
    Abstract: Provided according to some embodiments of the invention are topical gels that may release nitric oxide. Also provided are methods of using such topical gels in the treatment of wounds and other skin ailments.
    Type: Application
    Filed: July 18, 2017
    Publication date: November 2, 2017
    Inventors: Nathan Stasko, Susanne Bauman, Pranav R. Joshi
  • Patent number: 9757397
    Abstract: Provided according to some embodiments of the invention are methods of manufacturing a pharmaceutical composition. In some embodiments, such methods include homogenizing at a first excipient composition that includes a viscosity agent and at least one solvent to form a first premix composition; separately homogenizing at least one active pharmaceutical ingredient (API) and a second excipient composition to form a second premix composition; and combining the first premix composition and the second premix composition to form the composition. The pre-mixing of constituents may increase the stability of the API and provide uniformity of the dispersion of the constituents throughout the final topical composition.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: September 12, 2017
    Assignee: Novan, Inc.
    Inventors: Eleftherios Kougoulos, Nathan Stasko
  • Publication number: 20170246205
    Abstract: The present invention relates to bath compositions that may release nitric oxide when combined with an aqueous solution, thereby producing a nitric oxide releasing soak and/or bath. The present invention also relates to methods of using nitric oxide releasing bath compositions.
    Type: Application
    Filed: May 3, 2017
    Publication date: August 31, 2017
    Inventors: Nathan Stasko, Ryan Doxey
  • Patent number: 9737561
    Abstract: Provided according to some embodiments of the invention are topical gels that may release nitric oxide. Also provided are methods of using such topical gels in the treatment of wounds and other skin ailments.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: August 22, 2017
    Assignee: Novan, Inc.
    Inventors: Nathan Stasko, Susanne Bauman, Pranav R. Joshi
  • Publication number: 20170216197
    Abstract: The present invention relates generally to topical antiviral compositions and methods of using the same.
    Type: Application
    Filed: July 10, 2015
    Publication date: August 3, 2017
    Inventors: Kimberly McHale, Ryan Doxey, Nathan Stasko
  • Patent number: 9713652
    Abstract: Provided according to some embodiments of the invention are methods of forming co-condensed silica particles. In some embodiments, the methods include reacting a thiol-containing silane and a backbone alkoxysilane in a reaction solution that comprises water to form thiol-functionalized co-condensed silica particles, wherein the thiol-functionalized co-condensed silica particles include a polysiloxane matrix and at least some of thiol groups are present within the polysiloxane matrix; and reacting the thiol-functionalized co-condensed silica particles with a nitrosating agent to provide the S-nitrosothiol-functionalized co-condensed silica particles. In some embodiments, provided are S-nitrosothiol-functionalized co-condensed silica particles.
    Type: Grant
    Filed: August 26, 2013
    Date of Patent: July 25, 2017
    Assignees: The University of North Carolina at Chapel Hill, Novan, Inc.
    Inventors: Mark Schoenfisch, Daniel Riccio, Julia Nugent, Nathan Stasko
  • Patent number: 9669041
    Abstract: The present invention relates to bath compositions that may release nitric oxide when combined with an aqueous solution, thereby producing a nitric oxide releasing soak and/or bath. The present invention also relates to methods of using nitric oxide releasing bath compositions.
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: June 6, 2017
    Assignee: Novan, Inc.
    Inventors: Nathan Stasko, Ryan Doxey
  • Publication number: 20170056437
    Abstract: Provided according to some embodiments of the invention are topical gels that may release nitric oxide. Also provided are methods of using such topical gels in the treatment of wounds and other skin ailments.
    Type: Application
    Filed: November 16, 2016
    Publication date: March 2, 2017
    Inventors: Nathan Stasko, Susanne Baurman, Pranav R. Joshi
  • Publication number: 20170028215
    Abstract: Systems and methods for phototherapeutic modulation of nitric oxide in mammalian tissue include use of a first wavelength and first radiant flux of light to stimulate enzymatic generation of nitric oxide, and use of a second wavelength and second radiant flux of light to stimulate release of nitric oxide from endogenous stores of nitric oxide. Pulsed light and/or partially non-overlapping light impingement windows may be used. Non-coherent light impinged on tissue may include a peak wavelength in a range of from 410 nm to 440 nm in the absence of light emissions having a peak wavelength of from 600 nm to 900 nm.
    Type: Application
    Filed: July 28, 2016
    Publication date: February 2, 2017
    Inventors: Nicholas William Medendorp, JR., Katelyn P. Reighard, Gerald H. Negley, Nathan Stasko
  • Publication number: 20170028214
    Abstract: Systems and methods for phototherapeutic modulation of nitric oxide in mammalian tissue include use of a first wavelength and first radiant flux of light to stimulate enzymatic generation of nitric oxide, and use of a second wavelength and second radiant flux of light to stimulate release of nitric oxide from endogenous stores of nitric oxide. Pulsed light and/or partially non-overlapping light impingement windows may be used. Non-coherent light impinged on tissue may include a peak wavelength in a range of from 410 nm to 440 nm in the absence of light emissions having a peak wavelength of from 600 nm to 900 nm.
    Type: Application
    Filed: July 28, 2016
    Publication date: February 2, 2017
    Inventors: Nathan Stasko, Nicholas William Medendorp, JR., Gerald H. Negley, Katelyn P. Reighard
  • Patent number: 9526738
    Abstract: Provided according to some embodiments of the invention are topical gels that may release nitric oxide. Also provided are methods of using such topical gels in the treatment of wounds and other skin ailments. The topical gels comprise diazeniutndiolate-functionalized polysiloxane macromolecules.
    Type: Grant
    Filed: August 20, 2010
    Date of Patent: December 27, 2016
    Assignee: Novan, Inc.
    Inventors: Nathan Stasko, Susanne Bauman, Pranav R. Joshi
  • Patent number: 9403852
    Abstract: The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.
    Type: Grant
    Filed: February 2, 2015
    Date of Patent: August 2, 2016
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Mark H. Schoenfisch, Jae Ho Shin, Nathan Stasko
  • Patent number: 9403851
    Abstract: The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: August 2, 2016
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Mark H. Schoenfisch, Jae Ho Shin, Nathan Stasko
  • Publication number: 20160083339
    Abstract: Provided here are nitric oxide-releasing compounds that include at least two different NO donor functional groups of the same class. In some embodiments, such nitric oxide-releasing compounds are macromolecules such as dendrimer and co-condensed silica. Pharmaceutical compositions, wound dressings, kits and methods of treatments are also provided herein.
    Type: Application
    Filed: December 7, 2015
    Publication date: March 24, 2016
    Inventors: Mark Schoenfisch, Yuan Lu, Nathan Stasko, Jian Bao
  • Patent number: 9289442
    Abstract: Provided herein are anhydrous compositions that include at least one viscosity increasing agent, at least one organic solvent and at least one humectant. Such compositions may also include at least one active pharmaceutical ingredient (API) and/or at least one water repellant. Related compositions, methods and kits are also provided.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: March 22, 2016
    Assignee: Novan, Inc.
    Inventors: Ryan Doxey, Nathan Stasko