Abstract: Systems and methods for transdermal drug delivery with controlled heat are provided. Such systems can comprise a heating apparatus that includes an exothermic chemical composition, typically in the form of individual heating elements. The heating apparatus can be exposed to ambient oxygen through a cover. The cover can reduce the amount of ambient oxygen capable of contacting the chemical composition compared to when the cover is not present. In some embodiments, the heating apparatus can include more than one heating element. The systems can further include a drug-containing layer that includes a drug. The drug-containing layer can have a surface area of about 50 cm2 to about 400 cm2. The systems of the present invention can be deliver ketoprofen in an amount sufficient to produce a mean blood plasma concentration of ketoprofen in a human subject of at least 45 ng/ml within four hours after initial application of the system to a skin surface.

Abstract: Jaundice, also known as hyperbilirubinemia, is a common condition experienced by newborn babies. In severe cases it is treated by intense phototherapy. Currently, special halogen lights and fiber optics are used to expose the baby's skin to blue light, which transforms bilirubin into more water-soluble forms that can be easily eliminated from the body. The problem is that these phototherapy devices are often cumbersome, uncomfortable, and expensive. They are impractical to own because of their expense and short term of use. The present invention is a phototherapy flashlight device that uses a powerful light-emitting diode (LED), to produce a specific wavelength of blue light. This bilirubin flashlight may be held by hand or positioned within a support structure to shine on a fixed area.