Patents by Inventor Nathan W. Levin
Nathan W. Levin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11234609Abstract: Techniques and apparatuses for determining fluid volumes of a patient are described. In one embodiment, for example, an apparatus may include at least one memory, and logic coupled to the at least one memory. The logic may be configured to receive baseline bioimpedance information for at least a portion of a human body at a baseline pressure, receive pressurized bioimpedance information of the portion of the human body at a pressurized pressure, the pressurized pressure greater than the baseline pressure and configured to substantially remove blood volume from the portion at the pressurized pressure, and determine at least one of interstitial fluid volume (VIT) or peripheral blood volume (BVP) based on the baseline bioimpedance information and the pressurized bioimpedance information. Other embodiments are described.Type: GrantFiled: July 10, 2018Date of Patent: February 1, 2022Assignee: Fresenius Medical Care Holdings, Inc.Inventors: Fansan Zhu, Peter Kotanko, Nathan W. Levin
-
Publication number: 20210178042Abstract: A peritoneal dialysis (PD) system for infusing a volume of PD solution into a patient's peritoneal cavity in order to perform peritoneal dialysis on the patient includes a peritoneal cavity monitor (PCM) that measures this volume of fluid in the patient's peritoneal cavity by segmental bioimpedance spectroscopy (SBIS), to thereby determine an ultrafiltration volume of fluid in the patient's peritoneal cavity, and a switch, controlled by the PCM, for filling the patient's peritoneal cavity and draining the patient's peritoneal cavity when the ultrafiltration volume is unchanged over time, significantly decreased, or decreasing at a significant rate.Type: ApplicationFiled: February 26, 2021Publication date: June 17, 2021Inventors: Fansan Zhu, Nathan W. Levin
-
Patent number: 10960122Abstract: A peritoneal dialysis (PD) system for infusing a volume of PD solution into a patient's peritoneal cavity in order to perform peritoneal dialysis on the patient includes a peritoneal cavity monitor (PCM) that measures this volume of fluid in the patient's peritoneal cavity by segmental bioimpedance spectroscopy (SBIS), to thereby determine an ultrafiltration volume of fluid in the patient's peritoneal cavity, and a switch, controlled by the PCM, for filling the patient's peritoneal cavity and draining the patient's peritoneal cavity when the ultrafiltration volume is unchanged over time, significantly decreased, or decreasing at a significant rate.Type: GrantFiled: June 7, 2013Date of Patent: March 30, 2021Assignee: Fresenius Medical Care Holdings, Inc.Inventors: Fansan Zhu, Nathan W. Levin
-
Patent number: 10953147Abstract: In an embodiment, the invention relates to methods, apparatus, computer programs and computer program products for estimating a dry weight of a dialysis patient comprising the steps of determining a first fluid status of the patient between treatment sessions in a first stage, determining a second fluid status of the patient during treatment sessions in a second stage and estimating the dry weight based on the second fluid status.Type: GrantFiled: May 10, 2017Date of Patent: March 23, 2021Assignee: Fresenius Medical Care Holdings, Inc.Inventors: Nathan W. Levin, Fansan Zhu, Peter Kotanko, Peter Wabel, Ciro Tetta
-
Patent number: 10952643Abstract: Apparatus is disclosed for measuring the circumference of a limb of an individual, e.g., the individual's arm and/or calf. The apparatus uses one or more magnetic strips which surround the limb and contain magnetic coding of length information. Tension is applied to the magnetic strip by a tensioning assembly, which can be a pressure cuff or a stepping motor, and a magnetic read head reads the magnetic coding of length information from the strip. When used in a bioimpedance analysis procedure, the length information can be used to convert measured voltage differences into normalized bioimpedance values, e.g., resistivity values.Type: GrantFiled: June 26, 2018Date of Patent: March 23, 2021Assignee: Fresenius Medical Care Holdings, Inc.Inventors: Fansan Zhu, Nathan W. Levin
-
Publication number: 20210015397Abstract: Methods and apparatus for predicting/estimating the dry weight of an individual, e.g., a patient undergoing dialysis treatment, are provided. The techniques employ a bioimpedance measurement (303) on the individual's calf (101) to obtain information regarding the extracellular fluid volume of the calf Using a measurement of the calfs circumference (309), a resistivity value is calculated, normalized by the individual's body mass index (BMI), and then offset by a reference value to obtain a new variable, ?nRho, which is shown, by comparison with a “gold standard” (FIGS. 5-9), to be highly effective in predicting/estimating dry weight (FIGS. 10-13 and 15-16). The techniques are easy to use and provide accurate dry weight predictions/estimations without substantially adding to the complexity or cost of dialysis procedures. The techniques can also be used for individuals who are not renal patients, e.g.Type: ApplicationFiled: September 25, 2020Publication date: January 21, 2021Inventors: Nathan W. Levin, Fansan Zhu
-
Patent number: 10820827Abstract: Methods and apparatus for predicting/estimating the dry weight of an individual, e.g., a patient undergoing dialysis treatment, are provided. The techniques employ a bioimpedance measurement (303) on the individual's calf (101) to obtain information regarding the extracellular fluid volume of the calf. Using a measurement of the calf's circumference (309), a resistivity value is calculated, normalized by the individual's body mass index (BMI), and then offset by a reference value to obtain a new variable, ?nRho, which is shown, by comparison with a “gold standard” (FIGS. 5-9), to be highly effective in predicting/estimating dry weight (FIGS. 10-13 and 15-16). The techniques are easy to use and provide accurate dry weight predictions/estimations without substantially adding to the complexity or cost of dialysis procedures. The techniques can also be used for individuals who are not renal patients, e.g.Type: GrantFiled: October 12, 2011Date of Patent: November 3, 2020Assignee: Fresenius Medical Care Holdings, Inc.Inventors: Nathan W. Levin, Fansan Zhu
-
Patent number: 10525186Abstract: A method of performing regional citrate anticoagulant dialysis of a patient's blood includes flowing blood from and back to the patient through an extracorporeal circuit including a dialyzer having semi-permeable dialysis membranes and a dialysate chamber surrounding the membranes. The method further includes flowing a dialysate containing calcium and citrate through the dialysate chamber of the dialyzer and introducing citrate into the patient's blood upstream of the dialyzer, whereby the patient's blood is dialyzed. The method can further include predicting the concentration of systemic ionized calcium in the blood of the patient at any point in the dialysis treatment or post-dialysis, such as by a mathematical model. The method can further include statistically correcting the preliminary predicted post-dialysis concentration of systemic ionized calcium in the patient's blood to provide a final predicted post-dialysis systemic ionized calcium concentration.Type: GrantFiled: August 19, 2014Date of Patent: January 7, 2020Assignee: Fresenius Medical Care Holdings, Inc.Inventors: Peter Kotanko, Stephan Thijssen, Nathan W. Levin
-
Patent number: 10362968Abstract: Apparatus is disclosed for measuring the circumference of a limb of an individual, e.g., the individual's arm and/or calf. The apparatus uses one or more magnetic strips which surround the limb and contain magnetic coding of length information. Tension is applied to the magnetic strip by a tensioning assembly, which can be a pressure cuff or a stepping motor, and a magnetic read head reads the magnetic coding of length information from the strip. When used in a bioimpedance analysis procedure, the length information can be used to convert measured voltage differences into normalized bioimpedance values, e.g., resistivity values.Type: GrantFiled: April 17, 2013Date of Patent: July 30, 2019Assignee: FRESENIUS MEDICAL CARE HOLDINGS, INC.Inventors: Fansan Zhu, Nathan W. Levin
-
Publication number: 20190183385Abstract: Apparatus is disclosed for measuring the circumference of a limb of an individual, e.g., the individual's arm and/or calf. The apparatus uses one or more magnetic strips which surround the limb and contain magnetic coding of length information. Tension is applied to the magnetic strip by a tensioning assembly, which can be a pressure cuff or a stepping motor, and a magnetic read head reads the magnetic coding of length information from the strip. When used in a bioimpedance analysis procedure, the length information can be used to convert measured voltage differences into normalized bioimpedance values, e.g., resistivity values.Type: ApplicationFiled: April 17, 2013Publication date: June 20, 2019Inventors: Fansan ZHU, Nathan W. LEVIN
-
Patent number: 10319478Abstract: A method of adjusting a patient's undesired hematocrit and/or hemoglobin concentration to a value within a desired range at a predetermined time with an erythropoiesis stimulating agent (ESA) regimen includes obtaining patient parameters required for input into a model for predicting the patient's hematocrit and/or hemoglobin concentration at a predetermined time with a selected ESA administration regimen, and employing the patient parameters and an initially selected EPO administration regimen in the model to predict the patient's hematocrit and/or hemoglobin concentration at the predetermined time with the initially selected ESA administration regimen.Type: GrantFiled: September 7, 2012Date of Patent: June 11, 2019Assignee: Fresenius Medical Care Holdings, Inc.Inventors: Doris Helene Fuertinger, Franz Kappel, Peter Kotanko, Nathan W. Levin, Stephan Thijssen
-
Patent number: 10203321Abstract: The invention is directed to a method of identifying a patient undergoing periodic hemodialysis treatments at increased risk for death that includes determining at least one of the patient's clinical or biochemical parameters, consisting of serum bicarbonate concentration level, serum potassium concentration level, serum calcium concentration level, hemoglobin concentration level, serum phosphorus concentration level, neutrophil to lymphocyte ratio, equilibrated normalized protein catabolic rate (enPCR), equilibrated fractional clearance of total body water by dialysis and residual kidney function (eKdrt/V), EPO resistance index, transferrin saturation index, serum ferritin concentration level, serum creatinine concentration level, platelet count, Aspartat-Aminotransferase level, and Alanin-Aminotransferase level at periodic hemodialysis treatments, and identifying a patient as having an increased risk for death if the patient has a significant change in the rate of change of at least one of the patient's cliType: GrantFiled: December 1, 2011Date of Patent: February 12, 2019Assignee: Fresenius Medical Care Holdings, Inc.Inventors: Peter Kotanko, Stephan Thijssen, Len Usvyat, Nathan W. Levin
-
Publication number: 20190015013Abstract: Techniques and apparatuses for determining fluid volumes of a patient are described. In one embodiment, for example, an apparatus may include at least one memory, and logic coupled to the at least one memory. The logic may be configured to receive baseline bioimpedance information for at least a portion of a human body at a baseline pressure, receive pressurized bioimpedance information of the portion of the human body at a pressurized pressure, the pressurized pressure greater than the baseline pressure and configured to substantially remove blood volume from the portion at the pressurized pressure, and determine at least one of interstitial fluid volume (VIT) or peripheral blood volume (BVP) based on the baseline bioimpedance information and the pressurized bioimpedance information. Other embodiments are described.Type: ApplicationFiled: July 10, 2018Publication date: January 17, 2019Inventors: Fansan Zhu, Peter Kotanko, Nathan W. Levin
-
Publication number: 20180303380Abstract: Apparatus is disclosed for measuring the circumference of a limb of an individual, e.g., the individual's arm and/or calf. The apparatus uses one or more magnetic strips which surround the limb and contain magnetic coding of length information. Tension is applied to the magnetic strip by a tensioning assembly, which can be a pressure cuff or a stepping motor, and a magnetic read head reads the magnetic coding of length information from the strip. When used in a bioimpedance analysis procedure, the length information can be used to convert measured voltage differences into normalized bioimpedance values, e.g., resistivity values.Type: ApplicationFiled: June 26, 2018Publication date: October 25, 2018Inventors: Fansan ZHU, Nathan W. LEVIN
-
Patent number: 9974491Abstract: A method of detecting an indication of a potential intradialytic morbid event (IME) by monitoring a patient's condition during excess fluid removal by ultrafiltration during a hemodialysis treatment includes determining the patient's relative blood volume (RBV), and removing a portion of the volume of excess fluid from blood of the patient at an initial ultrafiltration rate while periodically monitoring a second derivative over time of the relative blood volume (SDRBV). The method then includes continuing to remove excess fluid from blood of the patient at the same ultrafilration rate, or, optionally, incrementally increasing the ultrafiltration rate. The method further includes triggering an alarm for an IME for the patient if the SDRBV is in a range of between a low SDRBV alarm level and a high SDRBV alarm level, and, alternatively or additionally monitoring the patient's normalized blood pressure ratio, and taking a remedial action if the alarm is triggered.Type: GrantFiled: August 27, 2013Date of Patent: May 22, 2018Assignee: FRESENIUS MEDICAL CARE HOLDINGS, INC.Inventors: Fansan Zhu, Peter Kotanko, Stephan Thijssen, Nathan W. Levin
-
Patent number: 9883799Abstract: The invention is directed to a method of identifying a patient undergoing periodic hemodialysis treatments at increased risk for death that includes determining at least one of the patient's clinical or biochemical parameters, including systolic blood pressure, serum albumin concentration level, body weight, body temperature, serum bicarbonate concentration level, serum potassium concentration level, serum calcium concentration level, hemoglobin concentration level, serum phosphorus concentration level, neutrophil to lymphocyte ratio, equilibrated normalized protein catabolic rate (enPCR), equilibrated fractional clearance of total body water by dialysis and residual kidney function (eKdrt/V), EPO resistance index, transferrin saturation index, serum ferritin concentration level, serum creatinine concentration level, platelet count, Aspartat-Aminotransferase level, and Alanin-Aminotransferase level at periodic hemodialysis treatments, and identifying a patient as having an increased risk for death if the patiType: GrantFiled: December 2, 2010Date of Patent: February 6, 2018Assignee: Fresenius Medical Care Holdings, Inc.Inventors: Peter Kotanko, Stephan Thijssen, Len Usvyat, Nathan W. Levin
-
Publication number: 20170239408Abstract: In an embodiment, the invention relates to methods, apparatus, computer programs and computer program products for estimating a dry weight of a dialysis patient comprising the steps of determining a first fluid status of the patient between treatment sessions in a first stage, determining a second fluid status of the patient during treatment sessions in a second stage and estimating the dry weight based on the second fluid status.Type: ApplicationFiled: May 10, 2017Publication date: August 24, 2017Inventors: Nathan W. Levin, Fansan Zhu, Peter Kotanko, Peter Wabel, Ciro Tetta
-
Patent number: 9675294Abstract: In an embodiment, the invention relates to methods, apparatus, computer programs and computer program products for estimating a dry weight of a dialysis patient comprising the steps of determining a first fluid status of the patient between treatment sessions in a first stage, determining a second fluid status of the patient during treatment sessions in a second stage and estimating the dry weight based on the second fluid status.Type: GrantFiled: September 18, 2012Date of Patent: June 13, 2017Assignees: FRESENIUS MEDICAL CARE HOLDINGS, INC., FRESENIUS MEDICAL CARE DEUTSCHLAND, GMBHInventors: Nathan W. Levin, Fansan Zhu, Peter Kotanko, Peter Wabel, Ciro Tetta
-
Patent number: 9679111Abstract: A method of adjusting a patient's undesired hematocrit and/or hemoglobin concentration to a value within a desired range at a predetermined time with an erythropoiesis stimulating agent (ESA) regimen includes obtaining patient parameters required for input into a model for predicting the patient's hematocrit and/or hemoglobin concentration at a predetermined time with a selected ESA administration regimen, the model including iron homeostasis, and employing the patient parameters and an initially selected ESA administration regimen in the model to predict the patient's hematocrit and/or hemoglobin concentration at the predetermined time with the initially selected ESA administration regimen. The method then includes administering ESA to the patient with an ESA administration regimen predicted to adjust the patient's hematocrit and/or hemoglobin concentration to the desired range at the predetermined time. The method can be implemented in a hemodialysis system.Type: GrantFiled: November 5, 2013Date of Patent: June 13, 2017Assignee: Fresenius Medical Care Holdings, Inc.Inventors: Doris Helene Fuertinger, Franz Kappel, Peter Kotanko, Nathan W. Levin, Stephan Thijssen
-
Publication number: 20160007884Abstract: Apparatus is disclosed for measuring the circumference of a limb of an individual, e.g., the individual's arm and/or calf. The apparatus uses one or more magnetic strips which surround the limb and contain magnetic coding of length information. Tension is applied to the magnetic strip by a tensioning assembly, which can be a pressure cuff or a stepping motor, and a magnetic read head reads the magnetic coding of length information from the strip. When used in a bioimpedance analysis procedure, the length information can be used to convert measured voltage differences into normalized bioimpedance values, e.g., resistivity values.Type: ApplicationFiled: April 17, 2013Publication date: January 14, 2016Inventors: Fansan ZHU, Nathan W. LEVIN