Abstract: Compositions, e.g., pharmaceutical compositions, nutritional compositions, medical foods, and food ingredients, as well as their methods of use, are provided, for treating diseases associated with hyperammonemia, e.g., urea cycle disorders (UCD) and hepatic encephalopathy (HE), e.g., minimal HE (MHE) and overt HE (OHE), and modulating enzyme activities and levels of microbes and taxa, and metabolites (e.g., ammonia) in the microbiome of a subject.

Abstract: In some aspects, fusosome compositions and methods are described herein that comprise membrane enclosed preparations, comprising a fusogen. In some embodiments, the fusosome can fuse to the target cell, thereby delivering complex biologic agents to the target cell cytoplasm.

Abstract: The present disclosure relates generally to compositions of synthetic bifunctional molecules comprising a first domain that specifically binds to a target ribonucleic acid sequence and a second domain that specifically binds to a target protein, and uses thereof.

Abstract: Processes, as well as associated systems and computer program (software) products, are disclosed for the biological conversion of CO into desired end products such as ethanol. The control methodologies used for these processes can advantageously result in a reduced time required for a batch operation or other initial operating period, prior to achieving a continuous operation, which may be demarcated either by the addition of fresh culture medium at a defined flow rate or by another process initiation target. The control methodologies may alternatively, or in combination, improve a process performance parameter, such as productivity of the desired end product or bacterial growth rate, during this batch operation or other initial operating period.

Abstract: The present disclosure relates generally to compositions of synthetic bifunctional molecules comprising a first domain that specifically binds to a target ribonucleic acid and a second domain that specifically binds to a target protein, and uses thereof.

Abstract: The present disclosure relates generally to compositions of synthetic bifunctional molecules comprising a first domain that specifically binds to a target ribonucleic acid and a second domain that specifically binds to a target polypeptide, and uses thereof.

Abstract: In some aspects, fusosome compositions and methods are described herein that comprise membrane enclosed preparations, comprising a fusogen. In some embodiments, the fusosome can the target cell, thereby delivering complex biologic agents to the target cell cytoplasm.

Abstract: A vehicle component such as an axle spindle or suspension beam (3) is connected to a tubular vehicle axle (1) by fitting a connector sleeve (2) onto the axle and subjecting the assembly to a crimping operation in which plural depressions (206,2018) are formed by indentation in the connector sleeve and the axle wall at the connection region (11,12) to fix the connector sleeve on the tubular axle. In the described proposals a solid lubricant (4) such as molybdenum disulphide is applied at the connection region between the connector sleeve (2) and axle (1), before crimping. The further vehicle component (3) is then connected to the connector sleeve (2) by welding.

Abstract: Compositions, e.g., pharmaceutical compositions, nutritional compositions, medical foods, and food ingredients, as well as their methods of use, are provided, for treating diseases associated with hyperammonemia, e.g., urea cycle disorders (UCD) and hepatic encephalopathy (HE), e.g., minimal HE (MHE) and overt HE (OHE), and modulating enzyme activities and levels of microbes and taxa, and metabolites (e.g., ammonia) in the microbiome of a subject.

Abstract: This disclosure provides, e.g., cytobiologic compositions and methods of use thereof. The cytobiologics can be used, e.g., to deliver a protein or nucleic acid to a target cell.

Abstract: An axle/suspension system (1) has an axle (5) supported from the frame of the vehicle by a pair of rigid longitudinal beams (4) pivoted to frame hangers (3). Air springs (7) and shock absorbers (8) connect between the rigid beams (4) and the frame above to control suspension movement. The axle/suspension system is particularly suited as a mid-lift axle on the tractor of a tractor-trailer vehicle. A characteristic feature is the pivotal connection (21) between each hanger (3) and beam (4), which is through a resilient bush (6) having a compliance ratio—being a ratio of the longitudinal spring rate to the vertical spring rate—of at least 10:1.

Abstract: A vehicle component such as an axle spindle or suspension beam (3) is connected to a tubular vehicle axle (1) by fitting a connector sleeve (2) onto the axle and subjecting the assembly to a crimping operation in which plural depressions (206,2018) are formed by indentation in the connector sleeve and the axle wall at the connection region (11,12) to fix the connector sleeve on the tubular axle. In the described proposals a solid lubricant (4) such as molybdenum disulphide is applied at the connection region between the connector sleeve (2) and axle (1), before crimping. The further vehicle component (3) is then connected to the connector sleeve (2) by welding.

Abstract: In some aspects, fusosome compositions and methods are described herein that comprise membrane enclosed preparations, comprising a fusogen. In some embodiments, the fusosome can the target cell, thereby delivering complex biologic agents to the target cell cytoplasm.

Abstract: The present invention provides, among other things, systems (e.g., comprising compositions and/or methods) for diagnosis, prophylaxis, treatment, prevention, and/or characterization of influenza transmission and/or infection. The present invention also provides methods for monitoring influenza variants for their potential to present a pandemic risk to humans.

Abstract: An axle/suspension system (1) has an axle (5) supported from the frame of the vehicle by a pair of rigid longitudinal beams (4) pivoted to frame hangers (3). Air springs (7) and shock absorbers (8) connect between the rigid beams (4) and the frame above to control suspension movement. The axle/suspension system is particularly suited as a mid-lift axle on the tractor of a tractor-trailer vehicle. A characteristic feature is the pivotal connection (21) between each hanger (3) and beam (4), which is through a resilient bush (6) having a compliance ratio—being a ratio of the longitudinal spring rate to the vertical spring rate—of at least 10:1.

Abstract: Processes, as well as associated systems and computer program (software) products, are disclosed for the biological conversion of CO into desired end products such as ethanol. The control methodologies used for these processes can advantageously result in a reduced time required for a batch operation or other initial operating period, prior to achieving a continuous operation, which may be demarcated either by the addition of fresh culture medium at a defined flow rate or by another process initiation target. The control methodologies may alternatively, or in combination, improve a process performance parameter, such as productivity of the desired end product or bacterial growth rate, during this batch operation or other initial operating period.

Abstract: Processes, as well as associated systems and computer program (software) products, are disclosed for the biological conversion of CO into desired end products such as ethanol. The control methodologies used for these processes can advantageously result in a reduced time required for a batch operation or other initial operating period, prior to achieving a continuous operation, which may be demarcated either by the addition of fresh culture medium at a defined flow rate or by another process initiation target. The control methodologies may alternatively, or in combination, improve a process performance parameter, such as productivity of the desired end product or bacterial growth rate, during this batch operation or other initial operating period.

Abstract: Processes, as well as associated systems and computer program (software) products, are disclosed for the biological conversion of CO into desired end products such as ethanol. The control methodologies used for these processes can advantageously result in a reduced time required for a batch operation or other initial operating period, prior to achieving a continuous operation, which may be demarcated either by the addition of fresh culture medium at a defined flow rate or by another process initiation target. The control methodologies may alternatively, or in combination, improve a process performance parameter, such as productivity of the desired end product or bacterial growth rate, during this batch operation or other initial operating period.

Abstract: The present invention provides, among other things, technologies and methodologies for detection, treatment, and/or prevention of influenza transmission and/or infection. The present invention also provides technologies for monitoring influenza HA variants with particular degrees of susceptibility to mutation for human adaptation.

Abstract: A pipe cleaning assembly includes a main shaft defining an inner bore aligned along a first axis, the inner bore being able to couple in fluid communication with coiled tubing. A slide shaft is disposed around the main shaft, the slide shaft having a forward end, a rear end, and a plurality of fluid pathways. Each of the fluid pathways is in fluid communication between the forward end of the slide shaft and the read end of the slide shaft. Each of the fluid pathways has a forward end able to direct fluid toward an inner surface of a pipe. The slide shaft is able to slide along the main shaft between a first position and a second position, in the direction of the first axis. The first position permits fluid flow through the plurality of fluid pathways, from the rear end of the slide shaft to the forward end of the slide shaft. The second position restricts fluid flow through the plurality of fluid pathways, from the forward end of the slide shaft to the rear end of the slide shaft.