Patents by Inventor Nathan Wilson Stebbins

Nathan Wilson Stebbins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS FOR FACILITATING MEMBRANE FUSION AND USES THEREOF
    Publication number: 20240033227
    Abstract: In some aspects, fusosome compositions and methods are described herein that comprise membrane enclosed preparations, comprising a fusogen. In some embodiments, the fusosome can fuse to the target cell, thereby delivering complex biologic agents to the target cell cytoplasm.
    Type: Application
    Filed: January 13, 2023
    Publication date: February 1, 2024
    Inventors: Geoffrey A. von Maltzahn, John Miles Milwid, Michael Travis Mee, Jacob Rosenblum Rubens, Nathan Wilson Stebbins, Molly Krisann Gibson, Neal Francis Gordon, Bo Zhang, Kyle Marvin Trudeau, Brigham Jay Hartley, Tamar Rose Putiri, Kiana Mahdaviani, Matthew Milnes Dobbin
  • BIFUNCTIONAL MOLECULES AND METHODS OF USING THEREOF
    Publication number: 20230332145
    Abstract: The present disclosure relates generally to compositions of synthetic bifunctional molecules comprising a first domain that specifically binds to a target ribonucleic acid sequence and a second domain that specifically binds to a target protein, and uses thereof.
    Type: Application
    Filed: March 24, 2021
    Publication date: October 19, 2023
    Applicant: Flagship Pioneering, Inc.
    Inventors: Nathan Wilson STEBBINS, Benjamin Andrew PORTNEY, Eric Bruno VALEUR, Chih-Chi Yuan, Mitchell Guttman
  • BIFUNCTIONAL MOLECULES AND METHODS OF USING THEREOF
    Publication number: 20230167450
    Abstract: The present disclosure relates generally to compositions of synthetic bifunctional molecules comprising a first domain that specifically binds to a target ribonucleic acid and a second domain that specifically binds to a target protein, and uses thereof.
    Type: Application
    Filed: April 21, 2021
    Publication date: June 1, 2023
    Applicant: Flagship Pioneering, Inc.
    Inventors: Nathan Wilson STEBBINS, Benjamin Andrew PORTNEY, Eric Bruno VALEUR, Jacob Rosenblum RUBENS, Kaveh DANESHVAR, Alexandra Rachael SNEIDER, Mitchell GUTTMAN
  • BIFUNCTIONAL MOLECULES AND METHODS OF USING THEREOF
    Publication number: 20230158156
    Abstract: The present disclosure relates generally to compositions of synthetic bifunctional molecules comprising a first domain that specifically binds to a target ribonucleic acid and a second domain that specifically binds to a target polypeptide, and uses thereof.
    Type: Application
    Filed: April 21, 2021
    Publication date: May 25, 2023
    Applicant: Flagship Pioneering, Inc.
    Inventors: Nathan Wilson STEBBINS, Benjamin Andrew PORTNEY, Eric Bruno VALEUR, Jacob Rosenblum RUBENS, Kaveh DANESHVAR, Alexandra Rachael SNEIDER
  • Compositions for facilitating membrane fusion and uses thereof
    Patent number: 11576872
    Abstract: In some aspects, fusosome compositions and methods are described herein that comprise membrane enclosed preparations, comprising a fusogen. In some embodiments, the fusosome can the target cell, thereby delivering complex biologic agents to the target cell cytoplasm.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: February 14, 2023
    Assignee: FLAGSHIP PIONEERING INNOVATIONS V, INC.
    Inventors: Geoffrey A. von Maltzahn, John Miles Milwid, Michael Travis Mee, Jacob Rosenblum Rubens, Nathan Wilson Stebbins, Molly Krisann Gibson, Neal Francis Gordon, Bo Zhang, Kyle Marvin Trudeau, Brigham Jay Hartley, Tamar Rose Putiri, Kiana Mahdaviani, Matthew Milnes Dobbin
  • GLYCAN PREPARATIONS AND METHODS OF USE FOR HYPERAMMONEMIA
    Publication number: 20220233577
    Abstract: Compositions, e.g., pharmaceutical compositions, nutritional compositions, medical foods, and food ingredients, as well as their methods of use, are provided, for treating diseases associated with hyperammonemia, e.g., urea cycle disorders (UCD) and hepatic encephalopathy (HE), e.g., minimal HE (MHE) and overt HE (OHE), and modulating enzyme activities and levels of microbes and taxa, and metabolites (e.g., ammonia) in the microbiome of a subject.
    Type: Application
    Filed: November 3, 2018
    Publication date: July 28, 2022
    Inventors: Molly Krisann Gibson, Nathan Wilson Stebbins, Ruth Thieroff-Ekerdt, Geoffrey A. von Maltzahn
  • CYTOBIOLOGICS AND THERAPEUTIC USES THEREOF
    Publication number: 20210187018
    Abstract: This disclosure provides, e.g., cytobiologic compositions and methods of use thereof. The cytobiologics can be used, e.g., to deliver a protein or nucleic acid to a target cell.
    Type: Application
    Filed: December 7, 2018
    Publication date: June 24, 2021
    Applicant: FLAGSHIP PIONEERING INNOVATIONS V, INC.
    Inventors: Geoffrey A. von Maltzahn, John Miles Milwid, Jacob Rosenblum Rubens, Michael Travis Mee, Nathan Wilson Stebbins, Molly Krisann Gibson, Neal Francis Gordon, Bo Zhang, Kyle Marvin Trudeau, Brigham Jay Hartley, Tamar Rose Putiri, Kiana Mahdaviani, Jagesh Vijaykumar Shah, Michael Connor, Peter Anthony Jones
  • COMPOSITIONS FOR FACILITATING MEMBRANE FUSION AND USES THEREOF
    Publication number: 20200060980
    Abstract: In some aspects, fusosome compositions and methods are described herein that comprise membrane enclosed preparations, comprising a fusogen. In some embodiments, the fusosome can the target cell, thereby delivering complex biologic agents to the target cell cytoplasm.
    Type: Application
    Filed: May 8, 2018
    Publication date: February 27, 2020
    Inventors: Geoffrey A. von Maltzahn, John Miles Milwid, Michael Travis Mee, Jacob Rosenblum Rubens, Nathan Wilson Stebbins, Molly Krisann Gibson, Neal Francis Gordon, Bo Zhang, Kyle Marvin Trudeau, Brigham Jay Hartley, Tamar Rose Putiri, Kiana Mahdaviani, Matthew Milnes Dobbin
  • Human Adaptation of H7 HA
    Patent number: 10526375
    Abstract: The present invention provides, among other things, systems (e.g., comprising compositions and/or methods) for diagnosis, prophylaxis, treatment, prevention, and/or characterization of influenza transmission and/or infection. The present invention also provides methods for monitoring influenza variants for their potential to present a pandemic risk to humans.
    Type: Grant
    Filed: June 5, 2014
    Date of Patent: January 7, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Kannan Tharakaraman, Rahul Raman, Akila Jayaraman, Nathan Wilson Stebbins, Ram Sasisekharan
  • HUMAN ADAPTATION OF H5 INFLUENZA
    Publication number: 20140335504
    Abstract: The present invention provides, among other things, technologies and methodologies for detection, treatment, and/or prevention of influenza transmission and/or infection. The present invention also provides technologies for monitoring influenza HA variants with particular degrees of susceptibility to mutation for human adaptation.
    Type: Application
    Filed: February 7, 2014
    Publication date: November 13, 2014
    Applicant: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Rahul Raman, Kannan Tharakaraman, Karthik Viswanathan, Nathan Wilson Stebbins