Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: Systems and methods for radial gesture navigation are provided. In example embodiments, user input data is received from a user device. The user input data indicates a continuous physical user interaction associated with a display screen of the user device. An initial point and a current point are detected from the user input data. A radius distance for a circle that includes the current point and is centered about the initial point is determined. An action is selected from among multiple actions based on the radius distance being within a particular range among successive ranges along a straight line that starts at the initial point and extends through the circle. Each range among the successive ranges corresponds to a particular action among the multiple actions. The selected action is performed in response to detecting a completion of the continuous physical user interaction.

Abstract: One or more servers can implement a method including generating an information resource comprising a content package including first content, metadata of a content extension, and a script for displaying the first content, and transmitting the information resource to a client device to cause the client device to: display the first content within an inline frame; identify an interaction with a user interface feature; transmit, responsive to identifying the interaction, a content extension request based on the metadata of the content extension; receive, responsive to the content extension request, a second content item; responsive to identifying the interaction, expand the inline frame from the first size to a second size; and display, in the expanded inline frame, the second content item, the second content item different from the first content item.