Abstract: A hand-held instrument includes a sample probe for evaluating at least one constituent of a sample; a processor configured with machine executable code stored on machine readable media for controlling the instrument; a display for providing output of the instrument; and, a pointing device for selecting output of the display and providing input to the processor, the pointing device configured for facilitating the selecting while holding the instrument. A method of use, a computer program product and embodiments of sample analyzers are disclosed.