Patents by Inventor Nathaniel A. Hathaway

Nathaniel A. Hathaway has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for enhancing proteasome activity
    Patent number: 9201073
    Abstract: This invention relates to methods and compositions for enhancing proteasome activity in a cell. The methods and compositions for enhancing the activity of the proteasome in cells modulate the activity of Ubp6 (yeast) or Usp14 (human), an endogenous inhibitor of the proteasome. The methods and compositions partially or completely reduce the inhibitory activity of Usp14 on a proteasome, thereby specifically enhancing the protein-degradation activity of the proteasome. The invention also provides methods of screening to identify inhibitors of Ubp6, Usp14, and/or both Ubp6 and Usp14.
    Type: Grant
    Filed: September 10, 2013
    Date of Patent: December 1, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: Daniel J. Finley, John W. Hanna, Nathaniel A. Hathaway, Randall W. King, Byung-Hoon Lee
  • Methods and Compositions for Enhancing Proteasome Activity
    Publication number: 20140199706
    Abstract: This invention relates to methods and compositions for enhancing proteasome activity in a cell. The methods and compositions for enhancing the activity of the proteasome in cells modulate the activity of Ubp6 (yeast) or Usp14 (human), an endogenous inhibitor of the proteasome. The methods and compositions partially or completely reduce the inhibitory activity of Usp14 on a proteasome, thereby specifically enhancing the protein-degradation activity of the proteasome. The invention also provides methods of screening to identify inhibitors of Ubp6, Usp14, and/or both Ubp6 and Usp14.
    Type: Application
    Filed: September 10, 2013
    Publication date: July 17, 2014
    Applicant: President and Fellows of Harvard College
    Inventors: Daniel J. Finley, John W. Hanna, Nathaniel A. Hathaway, Randall W. King, Byung-Hoon Lee