Patents by Inventor Nathaniel Butlin

Nathaniel Butlin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Macrocyclic ligands with pendant chelating moieties and complexes thereof
    Patent number: 11951188
    Abstract: The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.
    Type: Grant
    Filed: March 7, 2019
    Date of Patent: April 9, 2024
    Assignee: LUMIPHORE, INC.
    Inventors: David Tatum, Jide Xu, Darren Magda, Nathaniel Butlin
  • MACROCYCLIC LIGANDS WITH PENDANT CHELATING MOIETIES AND COMPLEXES THEREOF
    Publication number: 20240067650
    Abstract: The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.
    Type: Application
    Filed: March 10, 2023
    Publication date: February 29, 2024
    Inventors: David Tatum, Jide Xu, Darren Magda, Nathaniel Butlin
  • Macrocyclic ligands with pendant chelating moieties and complexes thereof
    Patent number: 11603371
    Abstract: The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: March 14, 2023
    Assignee: LUMIPHORE, INC.
    Inventors: David Tatum, Jide Xu, Darren Magda, Nathaniel Butlin
  • MACROCYCLIC LIGANDS WITH PENDANT CHELATING MOIETIES AND COMPLEXES THEREOF
    Publication number: 20200405887
    Abstract: The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.
    Type: Application
    Filed: March 7, 2019
    Publication date: December 31, 2020
    Inventors: David TATUM, Jide XU, Darren MAGDA, Nathaniel BUTLIN
  • MACROCYCLIC LIGANDS WITH PENDANT CHELATING MOIETIES AND COMPLEXES THEREOF
    Publication number: 20200062757
    Abstract: The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.
    Type: Application
    Filed: March 25, 2019
    Publication date: February 27, 2020
    Inventors: David Tatum, Jide Xu, Darren Magda, Nathaniel Butlin
  • RADIOPHARMACEUTICAL COMPLEXES
    Publication number: 20200024234
    Abstract: The invention provides compounds such as chelating agents useful in chelating metal ions, particularly radionuclides, to provide metal ion complexes. The invention also provides methods of using the compounds and complexes of the invention, such as in therapeutic and diagnostic applications.
    Type: Application
    Filed: January 7, 2019
    Publication date: January 23, 2020
    Inventors: Jide Xu, Nathaniel Butlin, Darren Magda
  • Macrocyclic ligands with pendant chelating moieties and complexes thereof
    Patent number: 10239878
    Abstract: The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: March 26, 2019
    Assignee: LUMIPHORE, INC.
    Inventors: David Tatum, Jide Xu, Darren Magda, Nathaniel Butlin
  • MACROCYCLIC LIGANDS WITH PENDANT CHELATING MOIETIES AND COMPLEXES THEREOF
    Publication number: 20180194766
    Abstract: The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.
    Type: Application
    Filed: March 7, 2018
    Publication date: July 12, 2018
    Inventors: David Tatum, Jide Xu, Darren Magda, Nathaniel Butlin
  • Engineered antibody fragment that irreversibly binds an antigen
    Publication number: 20060063209
    Abstract: The present invention provides mutant antibodies with infinite affinity for a target antigen. The antibodies comprise a mutant amino acid at a position within or proximate to a complimentarity determining region of the antibody and a linker covalently bound to the mutant amino acid, the linker comprising a reactive functional group. Subsequent to binding an antigen, the reactive functional group is converted to a covalent bond by reaction with a group of complementary reactivity on the bound antigen. The invention also provides bispecific antibodies with infinite binding affinity that comprise a second domain that specifically binds a metal chelate. The invention further provides methods of using such antibodies to diagnose and treat diseases and conditions.
    Type: Application
    Filed: August 22, 2005
    Publication date: March 23, 2006
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Claude Meares, Nathaniel Butlin
  • Element-coded affinity tags
    Publication number: 20050059100
    Abstract: The present invention provides compositions and methods for detecting, analyzing, and identifying biomolecules. More particularly, the invention provides Element Coded Affinity Tags comprising a metal chelate and a metal ion and methods of using the tags to detect, analyze, and identify biomolecules including polypeptides, nucleic acids, lipids, and polysaccharides.
    Type: Application
    Filed: April 28, 2004
    Publication date: March 17, 2005
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Claude Meares, Paul Whetstone, Todd Corneillie, Nathaniel Butlin
  • Element-coded affinity tags
    Publication number: 20050042695
    Abstract: The present invention provides compositions and methods for detecting, analyzing, and identifying biomolecules. More particularly, the invention provides Element Coded Affinity Tags comprising a metal chelate and a metal ion and methods of using the tags to detect, analyze, and identify biomolecules including polypeptides, nucleic acids, lipids, and polysaccharides.
    Type: Application
    Filed: May 24, 2004
    Publication date: February 24, 2005
    Applicant: The Regents of the University of California
    Inventors: Claude Meares, Carlito Lebrilla, Nathaniel Butlin, Sarah Cheal, Todd Corneillie, Susan Lee, Paul Whetstone, Nicolas Young