Patents by Inventor Nathaniel C. Gilbert

Nathaniel C. Gilbert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Soluble and stable human 5-lipoxygenase
    Patent number: 8877476
    Abstract: A soluble and stable form of 5-lipoxygenase (5-LOX) has been made, 5-Lox is the enzyme which initiates leukotriene biosynthesis by catalyzing the two-step transformation of arachidomc acid to leukotriene A4 (LTA4). The soluble and stable 5-LOX is suitable for a number of applications, including, but not limited to, high throughput screening of 5-LOX inhibitors, structural analysis of the enzyme's active site, designing inhibitors based on the three-dimensional structure of the enzyme's active site, and synthesis of LTA4. Using Stable-5-LOX, the crystal structure for 5-LOX has been resolved and the amino acids defining the active site determined.
    Type: Grant
    Filed: May 31, 2011
    Date of Patent: November 4, 2014
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Marcia E. Newcomer, Sue G. Bartlett, Nathaniel C. Gilbert
  • A Soluble and Stable Human 5-Lipoxygenase
    Publication number: 20130210052
    Abstract: A soluble and stable form of 5-lipoxygenase (5-LOX) has been made, 5-Lox is the enzyme which initiates leukotriene biosynthesis by catalyzing the two-step transformation of arachidomc acid to leukotriene A4 (LTA4). The soluble and stable 5-LOX is suitable for a number of applications, including, but not limited to, high throughput screening of 5-LOX inhibitors, structural analysis of the enzyme's active site, designing inhibitors based on the three-dimensional structure of the enzyme's active site, and synthesis of LTA4. Using Stable-5-LOX, the crystal structure for 5-LOX has been resolved and the amino acids defining the active site determined.
    Type: Application
    Filed: May 31, 2011
    Publication date: August 15, 2013
    Inventors: Marcia E. Newcomer, Sue G. Bartlett, Nathaniel C. Gilbert