Patents by Inventor Nathaniel E. Brennen

Nathaniel E. Brennen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYNTHETIC ENHANCEMENT OF THE T-CELL ARMAMENTARIUM AS AN ANTI-CANCER THERAPY
    Publication number: 20180148480
    Abstract: The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods for using synthetically enhanced T-cells to treat cancer. The present invention also provides a T-cell engineered (a) to express at least one CAR that binds tumor antigens; and (b) to inducibly express a prostate-specific antigen (PSA)-activated pro-aerolysin (PA) upon tumor antigen recognition by CAR.
    Type: Application
    Filed: January 15, 2016
    Publication date: May 31, 2018
    Inventors: John T. Isaacs, Samuel R. Denmeade, Nathaniel E. Brennen
  • ALBUMIN-PROAEROLYSIN PRODRUGS
    Publication number: 20180008668
    Abstract: The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods for treating cancer using albumin-proaerolysin prodrugs. Accordingly, in one aspect, the present invention provides prodrug compositions. In certain embodiments, a prodrug composition comprises a prostate-specific antigen (PSA)-activated pro-aerolysin (PA), wherein a PSA cleavable linker replaces the native furin cleavage site within PA; and human serum albumin (HSA) or a fragment thereof fused to the N-terminus of the PSA-activated PA.
    Type: Application
    Filed: January 15, 2016
    Publication date: January 11, 2018
    Inventors: John T. Isaacs, Samuel R. Denmeade, Nathaniel E. Brennen