Patents by Inventor Nathaniel Graham

Nathaniel Graham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR CONTROLLING MERISTEM SIZE FOR CROP IMPROVEMENT
    Publication number: 20240301400
    Abstract: This invention relates to compositions and methods for modifying FACIATED EAR2 (FEA2) genes in plants, optionally to modify meristem size. The invention further relates to plants having increased kernel row number produced using the methods and compositions of the invention.
    Type: Application
    Filed: May 21, 2024
    Publication date: September 12, 2024
    Inventors: Dale Karlson, Devin O'Connor, Nathaniel Graham
  • Optimized CRISPR-Cas nucleases and base editors and methods of use thereof
    Patent number: 12084671
    Abstract: This invention relates to CRISPR-Cas nucleases codon optimized for expression in plants and nucleic acid constructs encoding base editors comprising a CRISPR-Cas nuclease and a deaminase domain, wherein the nucleic acid constructs are optimized for expression in a plant. The invention further relates to methods of modifying nucleic acids using the nucleic acid constructs.
    Type: Grant
    Filed: February 6, 2023
    Date of Patent: September 10, 2024
    Assignee: Pairwise Plants Services, Inc.
    Inventor: Nathaniel Graham
  • METHODS FOR CONTROLLING MERISTEM SIZE FOR CROP IMPROVEMENT
    Publication number: 20240279640
    Abstract: This invention relates to compositions and methods for modifying FACIATED EAR2 (FEA2) genes in plants, optionally to modify meristem size. The invention further relates to plants having increased kernel row number produced using the methods and compositions of the invention.
    Type: Application
    Filed: April 25, 2024
    Publication date: August 22, 2024
    Inventors: Dale Karlson, Devin O'Connor, Nathaniel Graham
  • Methods for controlling meristem size for crop improvement
    Patent number: 11999946
    Abstract: This invention relates to compositions and methods for modifying FACIATED EAR2 (FEA2) genes in plants, optionally to modify meristem size. The invention further relates to plants having increased kernel row number produced using the methods and compositions of the invention.
    Type: Grant
    Filed: March 25, 2021
    Date of Patent: June 4, 2024
    Assignee: Pairwise Plants Services, Inc.
    Inventors: Dale Karlson, Devin O'Connor, Nathaniel Graham
  • Suppression of shade avoidance response in plants
    Patent number: 11959072
    Abstract: This invention relates to compositions and methods for modifying Homeodomain-leucine zipper (HD-Zip) transcription factors in plants to suppress shade avoidance response in plants. The invention further relates to plants produced using the methods and compositions of the invention.
    Type: Grant
    Filed: January 29, 2021
    Date of Patent: April 16, 2024
    Assignee: Pairwise Plants Services, Inc.
    Inventors: Nicholas Bate, Yongjoo Kim, Nathaniel Graham, Julius Mojica
  • Optimized CRISPR-Cas nucleases and base editors and methods of use thereof
    Patent number: 11913005
    Abstract: This invention relates to CRISPR-Cas nucleases codon optimized for expression in plants and nucleic acid constructs encoding base editors comprising a CRISPR-Cas nuclease and a deaminase domain, wherein the nucleic acid constructs are optimized for expression in a plant. The invention further relates to methods of modifying nucleic acids using the nucleic acid constructs.
    Type: Grant
    Filed: October 20, 2022
    Date of Patent: February 27, 2024
    Assignee: Pairwise Plants Services, Inc.
    Inventor: Nathaniel Graham
  • OPTIMIZED CRISPR-CAS NUCLEASES AND BASE EDITORS AND METHODS OF USE THEREOF
    Publication number: 20230183726
    Abstract: This invention relates to CRISPR-Cas nucleases codon optimized for expression in plants and nucleic acid constructs encoding base editors comprising a CRISPR-Cas nuclease and a deaminase domain, wherein the nucleic acid constructs are optimized for expression in a plant. The invention further relates to methods of modifying nucleic acids using the nucleic acid constructs.
    Type: Application
    Filed: February 6, 2023
    Publication date: June 15, 2023
    Inventors: Nathaniel Graham, Aaron Hummel, Yongjoo Kim, Joseph Matthew Watts
  • METHODS AND COMPOSITIONS FOR INCREASING RESISTANCE TO EAR ROT AND STEM ROT DISEASE IN MAIZE
    Publication number: 20230175006
    Abstract: This invention relates to compositions and methods for modifying LOX genes and inmaize plants to increase resistance to ear rot and/or stalk rot disease. The invention further relates to plants having increased resistance to ear rot and/or stalk rot produced using the methods and compositions of the invention.
    Type: Application
    Filed: April 6, 2021
    Publication date: June 8, 2023
    Inventors: Andrew Fister, Nathaniel Graham
  • OPTIMIZED CRISPR-CAS NUCLEASES AND BASE EDITORS AND METHODS OF USE THEREOF
    Publication number: 20230114342
    Abstract: This invention relates to CRISPR-Cas nucleases codon optimized for expression in plants and nucleic acid constructs encoding base editors comprising a CRISPR-Cas nuclease and a deaminase domain, wherein the nucleic acid constructs are optimized for expression in a plant. The invention further relates to methods of modifying nucleic acids using the nucleic acid constructs.
    Type: Application
    Filed: October 20, 2022
    Publication date: April 13, 2023
    Inventors: Nathaniel Graham, Aaron Hummel, Yongjoo Kim, Joseph Matthew Watts
  • METHODS AND COMPOSITIONS FOR REDUCING POD SHATTER IN CANOLA
    Publication number: 20230087522
    Abstract: This invention relates to compositions and methods for modifying SHATTERPROOF MARS-BOX (SHP) genes in canola plants, optionally to reduce pod shattering. The invention further relates to canola plants having reduced pod shatter produced using the methods and compositions of the invention.
    Type: Application
    Filed: September 21, 2022
    Publication date: March 23, 2023
    Inventors: Brian Charles Wilding Crawford, Nathaniel Graham, Lolita George Mathew
  • Optimized CRISPR-Cas nucleases and base editors and methods of use thereof
    Patent number: 11591607
    Abstract: This invention relates to CRISPR-Cas nucleases codon optimized for expression in plants and nucleic acid constructs encoding base editors comprising a CRISPR-Cas nuclease and a deaminase domain, wherein the nucleic acid constructs are optimized for expression in a plant. The invention further relates to methods of modifying nucleic acids using the nucleic acid constructs.
    Type: Grant
    Filed: October 23, 2020
    Date of Patent: February 28, 2023
    Assignee: Pairwise Plants Services, Inc.
    Inventors: Nathaniel Graham, Aaron Hummel, Yongjoo Kim, Joseph Matthew Watts
  • REPORTER CONSTRUCTS, COMPOSITIONS COMPRISING THE SAME, AND METHODS OF USE THEREOF
    Publication number: 20220403475
    Abstract: Described herein are nucleic acid constructs that can be used as a reporter along with compositions and systems comprising the same. Also described herein are methods of use of such constructs, compositions and/or systems.
    Type: Application
    Filed: June 9, 2022
    Publication date: December 22, 2022
    Inventors: Yongjoo Kim, Nathaniel Graham
  • METHODS FOR CONTROLLING MERISTEM SIZE FOR CROP IMPROVEMENT
    Publication number: 20210395767
    Abstract: This invention relates to compositions and methods for modifying a Leucine Rich Repeat Receptor Like Protein Kinase (LRR-RLK) gene in plants to increase kernel row number. The invention further relates to plants having increased kernel row number produced using the methods and compositions of the invention.
    Type: Application
    Filed: June 17, 2021
    Publication date: December 23, 2021
    Inventors: Devin O'Connor, Nathaniel Graham
  • METHODS FOR CONTROLLING MERISTEM SIZE FOR CROP IMPROVEMENT
    Publication number: 20210371873
    Abstract: This invention relates to compositions and methods for modifying CORYNE (CRN) genes in plants to optionally increase kernel row number and/or improve one or more yield traits. The invention further relates to plants having increased kernel row number and/or one or more improved yield traits produced using the methods and compositions of the invention.
    Type: Application
    Filed: June 1, 2021
    Publication date: December 2, 2021
    Inventors: Devin O'Connor, Nathaniel Graham
  • METHODS FOR CONTROLLING MERISTEM SIZE FOR CROP IMPROVEMENT
    Publication number: 20210301282
    Abstract: This invention relates to compositions and methods for modifying FACIATED EAR2 (FEA2) genes in plants, optionally to modify meristem size. The invention further relates to plants having increased kernel row number produced using the methods and compositions of the invention.
    Type: Application
    Filed: March 25, 2021
    Publication date: September 30, 2021
    Inventors: Dale Karlson, Devin O'Connor, Nathaniel Graham
  • NATURAL GUIDE ARCHITECTURES AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20210292754
    Abstract: Described herein are nonnaturally occurring nucleic acids that are and/or that provide a guide nucleic acid (e.g., a guide RNA). Further described herein are methods, compositions, systems (e.g., expression systems), and RNA structures (e.g., architectures), which may increase natural guide architecture (NGA) availability for Cas9 interactions.
    Type: Application
    Filed: March 16, 2021
    Publication date: September 23, 2021
    Inventors: Hae Jin Kim, Aaron Hummel, Shai Lawit, Aabid Shariff, Thomas Poorten, Nathaniel Graham
  • SUPPRESSION OF SHADE AVOIDANCE RESPONSE IN PLANTS
    Publication number: 20210238579
    Abstract: This invention relates to compositions and methods for modifying Homeodomain-leucine zipper (HD-Zip) transcription factors in plants to suppress shade avoidance response in plants. The invention further relates to plants produced using the methods and compositions of the invention.
    Type: Application
    Filed: January 29, 2021
    Publication date: August 5, 2021
    Inventors: Nicholas Bate, Yongjoo kim, Nathaniel Graham, Julius Mojica
  • COMPOSITIONS AND METHODS FOR RNA-TEMPLATED EDITING IN PLANTS
    Publication number: 20210147862
    Abstract: This invention relates to recombinant nucleic constructs comprising a DNA binding domain, an endonuclease and a reverse transcriptase and methods of use thereof for modifying nucleic acids in plants.
    Type: Application
    Filed: October 23, 2020
    Publication date: May 20, 2021
    Inventors: Aaron Hummel, Joseph Matthew Watts, Shai Joshua Lawit, Nathaniel Graham, Larry Gilbertson, Ervin Nagy, Linda Rymarquis
  • OPTIMIZED CRISPR-CAS NUCLEASES AND BASE EDITORS AND METHODS OF USE THEREOF
    Publication number: 20210147861
    Abstract: This invention relates to CRISPR-Cas nucleases codon optimized for expression in plants and nucleic acid constructs encoding base editors comprising a CRISPR-Cas nuclease and a deaminase domain, wherein the nucleic acid constructs are optimized for expression in a plant. The invention further relates to methods of modifying nucleic acids using the nucleic acid constructs.
    Type: Application
    Filed: October 23, 2020
    Publication date: May 20, 2021
    Inventors: Nathaniel Graham, Aaron Hummel, Yongjoo Kim, Joseph Matthew Watts
  • Cold water extractable tea leaf and process
    Patent number: 4051264
    Abstract: Cold water extractable tea leaf is prepared by treatment of fresh green tea with the enzyme tannase under anaerobic conditions. The cold water extractable tea leaf is also used to prepare an instant tea product.
    Type: Grant
    Filed: November 16, 1976
    Date of Patent: September 27, 1977
    Assignee: Thomas J. Lipton, Inc.
    Inventors: Gary Warner Sanderson, Andrew Charles Hoefler, Harold Nathaniel Graham, Philip Coggon