Patents by Inventor Nathaniel Grier

Nathaniel Grier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4172094
    Abstract: Novel diphenyl and loweralkyl substituted diphenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful because of their low toxicity, and as such are advantageously included as the active agent in surgical scrubs, antibacterial soaps, as preservatives in cosmetic preparations, and the like. They also can be used for topical treatment of dermatological conditions having a bacterial origin or implication such as Acne vulgaris.
    Type: Grant
    Filed: December 3, 1976
    Date of Patent: October 23, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Richard A. Dybas, Nathaniel Grier, Bruce E. Witzel
  • Patent number: 4161581
    Abstract: Novel polymers having a linear backbone which is free from both branching and cross-linking, comprising either tertiary or quaternized nitrogen atoms linked to each other through ethylene groups. These polymers are useful as antimicrobials, flocculating agents, antistatic agents, electroconductive agents for coating paper, chelating agents and bile acid binding agents, as well as in similar applications where their high charge to weight ratio and fully accessible nitrogen atoms can be employed. The polymers are obtained by the polymerization of an oxazoline, hydrolysis or direct reduction, nitrogen substitution, and optional quaternization of the resulting polymer.
    Type: Grant
    Filed: September 29, 1977
    Date of Patent: July 17, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Arthur F. Wagner, Nathaniel Grier, Tsung-Ying Shen
  • Patent number: 4159253
    Abstract: 1,3,5-s-Hexahydrotrisubstituted triazines exemplified by 1,3,5-tris(furfuryl)-1,3,5-hexahydro-s-triazines are useful as antimicrobial agents particularly when employed as a component of metal-working compositions subject to fungal and bacterial attack.
    Type: Grant
    Filed: May 22, 1978
    Date of Patent: June 26, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Bruce E. Witzei
  • Patent number: 4159254
    Abstract: 1,3,5-s-Hexahydrotrisubstituted triazines exemplified by 1,3,5-tris(tetrahydrofurfuryl)-1,3,5-hexahydro-s-triazines are useful as antimicrobial agents particularly when employed as a component of metal-working compositions subject to fungal and bacterial attack.
    Type: Grant
    Filed: May 22, 1978
    Date of Patent: June 26, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Bruce E. Witzel
  • Patent number: 4149983
    Abstract: Compositions of 1,3,5-tris-(furfuryl)hexahydro-s-triazine are useful as antimicrobial agents particularly when added to metal-working compositions subject to fungal and bacterial attack.
    Type: Grant
    Filed: April 3, 1978
    Date of Patent: April 17, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Bruce E. Witzel
  • Patent number: 4145426
    Abstract: Compounds of the structure: ##STR1## where A is either ##STR2## where R.sub.1 to R.sub.4 are various substituents are active as antibacterials and antifungals.
    Type: Grant
    Filed: July 18, 1977
    Date of Patent: March 20, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas, Bruce E. Witzel
  • Patent number: 4139559
    Abstract: A process for preparing 1-[1,5-di-(3,3-dimethylnorborn-2-yl)-3-pentyl]-1,5,9-triazanonane from 1,5-di-(3,3-dimethylnorborn-2-yl)-3-pentanone by reaction with ammonia to form, after reduction, 3-amino-[1,5-di-(3,3-dimethylnorborn-2-yl)pentane]. This latter compound is reacted with acrylonitrile, reduced, and the diamine product again reacted with acrylonitrile and again reduced. Alternative routes wherein the ketone is reduced to the novel alcohol and optionally the novel halide and either then reacted with 3,3'-iminobispropylamine to form the desired polyamine are also shown.
    Type: Grant
    Filed: January 16, 1978
    Date of Patent: February 13, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas, Robert A. Strelitz
  • Patent number: 4125719
    Abstract: 1,3,5-s-Hexahydrotrisubstituted triazines exemplified by 1,3,5-tris(furfuryl)-1,3,5-hexahydro-s-triazines are useful as antimicrobial agents particularly when employed as a component of metal-working compositions subject to fungal and bacterial attack.
    Type: Grant
    Filed: August 1, 1977
    Date of Patent: November 14, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Bruce E. Witzel
  • Patent number: 4119779
    Abstract: 1,3,5-s-Hexahydrotrisubstituted triazines exemplified by 1,3,5-tris(tetrahydrofurfuryl)-1,3,5-hexahydro-s-triazines are useful as antimicrobial agents particularly when employed as a component of metal-working compositions subject to fungal and bacterial attack.
    Type: Grant
    Filed: May 11, 1977
    Date of Patent: October 10, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Bruce E. Witzel
  • Patent number: 4100193
    Abstract: Novel dibicyclo [2.2.2] octyl dibicyclo [2.2.2] octenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful as hard surface disinfectants and as additives to oil well drilling muds, injection brines and industrial water where bacterial control is desired.
    Type: Grant
    Filed: June 10, 1976
    Date of Patent: July 11, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas, Robert A. Strelitz
  • Patent number: 4098726
    Abstract: Novel polymers having a linear backbone which is free from both branching and cross-linking, comprising quaternized nitrogen atoms linked to each other through trimethylene groups. By the term "linear backbone" is meant that the polymer has only acyclic groups, i. e. trimethylene, linking the nitrogen atoms in a single continuous chain; the polymer is free from "branching" when it has no repeating monomer units extending from the polymer backbone; and it is free from "cross-linking" when there is no joining of two linear backbones. These polymers are useful as antimicrobials, flocculating agents, antistatic agents, electroconductive agents for coating paper, chelating agents and bile acid binding agents, as well as in similar applications where their high charge to weight ratio and fully accessible nitrogen atoms can be employed. The polymers are obtained by the polymerization of dihydro-oxazine, reductive alkylation of the resulting polymer, followed by quaternization.
    Type: Grant
    Filed: April 1, 1977
    Date of Patent: July 4, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Arthur F. Wagner, Nathaniel Grier, Tsung-Ying Shen
  • Patent number: 4091020
    Abstract: Novel di-bicyclo[3.1.1] and [2.2.1]heptyl and dibicyclo[3.1.1] and [2.2.1]heptenyl ketones are useful as intermediates for preparing novel polyamines useful as antimicrobial agents, as well as algae inhibitors.
    Type: Grant
    Filed: August 23, 1976
    Date of Patent: May 23, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas
  • Patent number: 4079059
    Abstract: Novel diphenyl and loweralkyl substituted diphenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful because of their low toxicity, and as such are advantageously included as the active agent in surgical scrubs, antibacterial soaps, as preservatives in cosmetic preparations, and the like. They also can be used for topical treatment of dermatological conditions having a bacterial origin or implication such as Acne vulgaris.
    Type: Grant
    Filed: February 12, 1976
    Date of Patent: March 14, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Richard A. Dybas, Nathaniel Grier, Bruce E. Witzel
  • Patent number: 4070400
    Abstract: Novel diphenyl and loweralkyl substituted diphenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful because of their low toxicity, and as such are advantageously included as the active agent in surgical scrubs, antibacterial soaps, as preservatives in cosmetic preparations, and the like. They also can be used for topical treatment of dermatological conditions having a bacterial origin or implication such as Acne vulgaris.
    Type: Grant
    Filed: October 16, 1975
    Date of Patent: January 24, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Richard A. Dybas, Nathaniel Grier, Bruce E. Witzel
  • Patent number: 4065497
    Abstract: Novel dibicyclo [3.1.1] and [2.2.1] heptyl and dibicyclo [3.1.1] and [2.2.1] heptenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful as hard surface disinfectants and as additives to oil well drilling muds, injection brines and industrial water where bacterial control is desired.
    Type: Grant
    Filed: February 17, 1977
    Date of Patent: December 27, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas, Robert A. Strelitz
  • Patent number: 4061775
    Abstract: Novel diphenyl and loweralkyl substituted diphenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful because of their low toxicity, and as such are advantageously included as the active agent in surgical scrubs, antibacterial soaps, as preservatives in cosmetic preparations, and the like. They also can be used for topical treatment of dermatological conditions having a bacterial origin or implication such as Acne vulgaris.
    Type: Grant
    Filed: September 2, 1975
    Date of Patent: December 6, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Richard A. Dybas, Nathaniel Grier, Bruce E. Witzel
  • Patent number: 4060639
    Abstract: A composition comprising tris-(hydroxymethyl)aminomethane and dicyclohexyl-, dicyclohexenyl- and cyclohexylcyclohexenyl-alkyl polyamines, their acid addition salts, and mixtures thereof are useful as antibacterial agents. The composition is particularly useful because of the synergistic improvement obtained against strains of the genus Pseudomonas, as well as other genera.
    Type: Grant
    Filed: May 14, 1976
    Date of Patent: November 29, 1977
    Assignee: Merck & Co., Inc.
    Inventors: David P. Jacobus, Eugene L. Dulaney, Nathaniel Grier
  • Patent number: 4058625
    Abstract: A composition comprising tris-(hydroxymethyl)aminomethane and dibicyclo [3.1.1] and [2.2.1] heptyl and dibicyclo [3.1.1] and [2.2.1] heptenyl polyamines, their acid addition salts, and mixtures thereof are useful as antimicrobial agents. The composition is particularly useful because of the synergistic improvement obtained against strains of the genus Pseudomonas, as well as other genera.
    Type: Grant
    Filed: May 14, 1976
    Date of Patent: November 15, 1977
    Assignee: Merck & Co., Inc.
    Inventors: David P. Jacobus, Eugene L. Dulaney, Nathaniel Grier
  • Patent number: 4058624
    Abstract: A composition comprising tris-(hydroxymethyl)aminomethane and diphenyl and loweralkyl substituted diphenyl polyamines, their acid addition salts, and mixtures thereof are useful as antibacterial agents. The composition is particularly useful because of the synergistic improvement obtained against strains of the genus Pseudomonas, as well as other genera.
    Type: Grant
    Filed: May 14, 1976
    Date of Patent: November 15, 1977
    Assignee: Merck & Co., Inc.
    Inventors: David P. Jacobus, Eugene L. Dulaney, Nathaniel Grier
  • Patent number: 4049417
    Abstract: Novel dicyclohexyl, dicyclohexenyl and cyclohexylcyclohexenylalkyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful in agriculture to protect plants against diseases such as leaf, stem, and fruit spotting, internal discoloration and decay of fruits and vegetables. These compounds are particularly active against diseases caused by the genera Pseudomonas, Xanthomonas, Erwinia, and Corynebacterium.
    Type: Grant
    Filed: March 8, 1976
    Date of Patent: September 20, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Bruce E. Witzel, Nathaniel Grier, Richard A. Dybas, Robert A. Strelitz