Patents by Inventor Nathaniel Huebsch

Nathaniel Huebsch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240228926
    Abstract: A microwell array configured for high-throughput screening of micro-tissue and methods of using the same to prepare micro-tissue is disclosed. The microwell array includes a substrate having a plurality of wells, at least one longitudinal recess arranged in the bottom surface of each of the plurality of wells, and at least one micropillar arranged within the longitudinal recess at each end of the longitudinal recess. The microwell array advantageously can provide for high-throughput screening by enabling in vitro generation of three-dimensional micro-tissues that are accurate models of heart, skeletal muscle, neuronal, and other tissues in a device compatible with existing robotic liquid handlers to load cells into the devices, perform routine media changes, and add molecular probes and compounds when desired.
    Type: Application
    Filed: June 16, 2022
    Publication date: July 11, 2024
    Applicant: Organos, Inc.
    Inventors: Kevin E. Healy, Nathaniel Huebsch, Julia Schaletzky, Samuel Wall
  • Patent number: 11898167
    Abstract: The invention relates to devices, methods, kits, and compositions for in vitro generation of three-dimensional micro-tissues that are accurate models of heart, skeletal muscle, neuronal, and other tissues.
    Type: Grant
    Filed: October 26, 2020
    Date of Patent: February 13, 2024
    Assignees: The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Gladstone, The Regents of the University of California
    Inventors: Nathaniel Huebsch, Bruce Conklin, Kevin E. Healy, Peter Loskill
  • Publication number: 20230348847
    Abstract: Disclosed herein are methods of making a mold for use with cells, such as engineered tissue. The method includes printing a 3D printed resin mold, casting a hydrogel over the 3D printed resin mold to create a crosslinked hydrogel negative mold, and casting a silicone rubber elastomer over the hydrogel negative mold to create a master mold.
    Type: Application
    Filed: April 27, 2023
    Publication date: November 2, 2023
    Inventors: Nathaniel Huebsch, Daniel Simmons, David Schuftan, Guy Genin, Ghiska Ramahdita
  • Publication number: 20210123023
    Abstract: The invention relates to devices, methods, kits, and compositions for in vitro generation of three-dimensional micro-tissues that are accurate models of heart, skeletal muscle, neuronal, and other tissues.
    Type: Application
    Filed: October 26, 2020
    Publication date: April 29, 2021
    Inventors: Nathaniel Huebsch, Bruce Conklin, Kevin E. Healy, Peter Loskill
  • Patent number: 10851344
    Abstract: The invention relates to devices, methods, kits, and compositions for in vitro generation of three-dimensional micro-tissues that are accurate models of heart, skeletal muscle, neuronal, and other tissues.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: December 1, 2020
    Assignees: The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Gladstone, The Regents of The University of California
    Inventors: Nathaniel Huebsch, Bruce Conklin, Kevin E. Healy, Peter Loskill
  • Publication number: 20170211044
    Abstract: The invention relates to devices, methods, kits, and compositions for in vitro generation of three-dimensional micro-tissues that are accurate models of heart, skeletal muscle, neuronal, and other tissues.
    Type: Application
    Filed: August 7, 2015
    Publication date: July 27, 2017
    Inventors: Nathaniel Huebsch, Bruce Conklin, Kevin E. Healy, Peter Loskill