Patents by Inventor Nathaniel Jillette

Nathaniel Jillette has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TARGETED DNA DEMETHYLATION AND METHYLATION
    Publication number: 20240132557
    Abstract: Provided herein are, inter alia, compositions and methods for demethylating and methylating a target DNA sequences in a mammalian cell. The compositions and methods are, inter alia, useful for modulating the expression of a target gene, or to create a gene regulatory network.
    Type: Application
    Filed: August 23, 2023
    Publication date: April 25, 2024
    Applicant: The Jackson Laboratory
    Inventors: Albert Cheng, Aziz Taghbalout, Nathaniel Jillette
  • Targeted DNA demethylation and methylation
    Patent number: 11780895
    Abstract: Provided herein are, inter alia, compositions and methods for demethylating and methylating a target DNA sequences in a mammalian cell. The compositions and methods are, useful for activity modulation of a targeted gene, or to create a gene regulatory network.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: October 10, 2023
    Assignee: The Jackson Laboratory
    Inventors: Albert Cheng, Aziz Taghbalout, Nathaniel Jillette
  • Targeted Sequence Insertion Compositions and Methods
    Publication number: 20230295615
    Abstract: The invention described herein provides compositions and reagents for integrating large sequences (e.g., 150 bp or more) into a selected target DNA sequence via prime editing.
    Type: Application
    Filed: August 6, 2021
    Publication date: September 21, 2023
    Inventors: Albert Cheng, Nathaniel Jillette
  • THREE-COMPONENT CRISPR/CAS COMPLEX SYSTEM AND USES THEREOF
    Publication number: 20230071712
    Abstract: The invention described herein provides compositions and reagents for assembling a tripartite complex at a specific location of a target DNA. The invention also provides methods for using the complex to, for example, label a specific genomic locus, to regulate the expression of a target gene, or to create a gene regulatory network.
    Type: Application
    Filed: July 28, 2022
    Publication date: March 9, 2023
    Applicant: The Jackson Laboratory
    Inventors: Haoyi Wang, Albert Cheng, Nathaniel Jillette
  • Three-component CRISPR/Cas complex system and uses thereof
    Patent number: 11434484
    Abstract: The invention described herein provides compositions and reagents for assembling a tripartite complex at a specific location of a target DNA. The invention also provides methods for using the complex to, for example, label a specific genomic locus, to regulate the expression of a target gene, or to create a gene regulatory network.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: September 6, 2022
    Assignee: The Jackson Laboratory
    Inventors: Haoyi Wang, Albert Cheng, Nathaniel Jillette
  • ARTIFICIAL RNA-GUIDED SPLICING FACTORS
    Publication number: 20210388351
    Abstract: Provided herein, in some aspects, are compositions and methods for artificially modulating alternative splicing, for example, inducing exon inclusion and/or exon exclusion events. In some embodiments, a catalytically inactive programmable nuclease, such as dCasRx, is fused to an RNA-binding protein (or fragment or isoform thereof) and, when guided to a target of interest by a specific guide RNA (gRNA), can regulate alternative splicing in eukaryotic cells.
    Type: Application
    Filed: September 27, 2019
    Publication date: December 16, 2021
    Applicant: The Jackson Laboratory
    Inventors: Albert Cheng, Nathaniel Jillette
  • TRANSGENIC SELECTION METHODS AND COMPOSITIONS
    Publication number: 20200263197
    Abstract: The present disclosure provides a split intein selectable marker system for the production and selection of transgenic cells.
    Type: Application
    Filed: October 11, 2018
    Publication date: August 20, 2020
    Applicant: The Jackson Laboratory
    Inventors: Albert Cheng, Nathaniel Jillette, Menghan Du
  • TARGETED ENHANCED DNA DEMETHYLATION
    Publication number: 20190218261
    Abstract: Provided herein are, inter alia, compositions and methods for the delivery of enhanced demethylation activity to target DNA sequences in a mammalian cell. The compositions and methods are, useful for activity modulation of a targeted gene, or to create a gene regulatory network.
    Type: Application
    Filed: September 13, 2017
    Publication date: July 18, 2019
    Applicant: The Jackson Laboratory
    Inventors: Albert Cheng, Aziz Taghbalout, Nathaniel Jillette
  • THREE-COMPONENT CRISPR/CAS COMPLEX SYSTEM AND USES THEREOF
    Publication number: 20180094257
    Abstract: The invention described herein provides compositions and reagents for assembling a tripartite complex at a specific location of a target DNA. The invention also provides methods for using the complex to, for example, label a specific genomic locus, to regulate the expression of a target gene, or to create a gene regulatory network.
    Type: Application
    Filed: September 13, 2017
    Publication date: April 5, 2018
    Applicant: The Jackson Laboratory
    Inventors: Haoyi Wang, Albert Cheng, Nathaniel Jillette