Patents by Inventor Nathaniel Joseph McCaffrey
Nathaniel Joseph McCaffrey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230175060Abstract: Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.Type: ApplicationFiled: September 7, 2022Publication date: June 8, 2023Inventors: Adrian FEHR, Nathaniel Joseph MCCAFFREY, Stephen TURNER
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Publication number: 20210340616Abstract: An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device. The illumination may be received from a top, a side edge, and a bottom of the device. The waveguide assembly may include a nanoscale aperture disposed in the substrate and extending through the cladding. The aperture defines a reaction cell for receiving a set of reactants. In various aspects, the device includes a sensor element and the illumination pathway is through the sensor element. Waveguides and illumination devices, such as plasmonic illumination devices, are also disclosed. Methods for forming and operating the devices are also disclosed.Type: ApplicationFiled: March 30, 2021Publication date: November 4, 2021Inventors: Adrian FEHR, Nathaniel Joseph McCAFFREY, Stephen TURNER
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Patent number: 11001889Abstract: An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device. The illumination may be received from a top, a side edge, and a bottom of the device. The waveguide assembly may include a nanoscale aperture disposed in the substrate and extending through the cladding. The aperture defines a reaction cell for receiving a set of reactants. In various aspects, the device includes a sensor element and the illumination pathway is through the sensor element. Waveguides and illumination devices, such as plasmonic illumination devices, are also disclosed. Methods for forming and operating the devices are also disclosed.Type: GrantFiled: November 26, 2018Date of Patent: May 11, 2021Assignee: Pacific Biosciences of California, Inc.Inventors: Adrian Fehr, Nathaniel Joseph McCaffrey, Stephen Turner
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Patent number: 10724090Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.Type: GrantFiled: April 16, 2019Date of Patent: July 28, 2020Assignee: Pacific Biosciences of California, Inc.Inventors: Nathaniel Joseph McCaffrey, Stephen Turner, Ravi Saxena, Scott Edward Helgesen
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Patent number: 10640825Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.Type: GrantFiled: October 17, 2017Date of Patent: May 5, 2020Assignee: Pacific Biosciences of California, Inc.Inventors: Nathaniel Joseph McCaffrey, Stephen Turner, Ravi Saxena, Scott Edward Helgesen
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Publication number: 20190360042Abstract: An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device. The illumination may be received from a top, a side edge, and a bottom of the device. The waveguide assembly may include a nanoscale aperture disposed in the substrate and extending through the cladding. The aperture defines a reaction cell for receiving a set of reactants. In various aspects, the device includes a sensor element and the illumination pathway is through the sensor element. Waveguides and illumination devices, such as plasmonic illumination devices, are also disclosed. Methods for forming and operating the devices are also disclosed.Type: ApplicationFiled: November 26, 2018Publication date: November 28, 2019Inventors: Adrian Fehr, Nathaniel Joseph McCAFFREY, Stephen TURNER
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Publication number: 20190309361Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.Type: ApplicationFiled: April 16, 2019Publication date: October 10, 2019Inventors: Nathaniel Joseph MCCAFFREY, Stephen TURNER, Ravi SAXENA, Scott Edward HELGESEN
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Patent number: 10138515Abstract: An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device. The illumination may be received from a top, a side edge, and a bottom of the device. The waveguide assembly may include a nanoscale aperture disposed in the substrate and extending through the cladding. The aperture defines a reaction cell for receiving a set of reactants. In various aspects, the device includes a sensor element and the illumination pathway is through the sensor element. Waveguides and illumination devices, such as plasmonic illumination devices, are also disclosed. Methods for forming and operating the devices are also disclosed.Type: GrantFiled: September 3, 2015Date of Patent: November 27, 2018Assignee: Pacific Biosciences of California, Inc.Inventors: Adrian Fehr, Nathaniel Joseph McCaffrey, Stephen Turner
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Publication number: 20180155781Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.Type: ApplicationFiled: October 17, 2017Publication date: June 7, 2018Inventors: Nathaniel Joseph MCCAFFREY, Stephen TURNER, Ravi SAXENA, JR., Scott Edward HELGESEN
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Patent number: 9822410Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.Type: GrantFiled: September 21, 2016Date of Patent: November 21, 2017Assignee: Pacific Biosciences of California, Inc.Inventors: Nathaniel Joseph McCaffrey, Stephen Turner, Ravi Saxena, Sr., Scott Edward Helgesen
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Publication number: 20170137877Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.Type: ApplicationFiled: September 21, 2016Publication date: May 18, 2017Inventors: Nathaniel Joseph MCCAFFREY, Stephen TURNER, Ravi SAXENA, SR., Scott Edward HELGESEN
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Publication number: 20170030834Abstract: Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.Type: ApplicationFiled: June 28, 2016Publication date: February 2, 2017Inventors: Adrian FEHR, Nathaniel Joseph MCCAFFREY, Stephen TURNER
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Patent number: 9488584Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.Type: GrantFiled: June 4, 2015Date of Patent: November 8, 2016Assignee: Pacific Bioscience of California, Inc.Inventors: Nathaniel Joseph McCaffrey, Stephen Turner, Ravi Saxena, Scott Edward Helgesen
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Patent number: 9410891Abstract: Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.Type: GrantFiled: February 18, 2011Date of Patent: August 9, 2016Assignee: Pacific Biosciences of California, Inc.Inventors: Adrian Fehr, Nathaniel Joseph McCaffrey, Stephen Turner
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Patent number: 9291569Abstract: Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.Type: GrantFiled: March 9, 2015Date of Patent: March 22, 2016Assignee: Pacific Biosciences of California, Inc.Inventors: Adrian Fehr, Nathaniel Joseph McCaffrey, Stephen Turner
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Patent number: 9291568Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.Type: GrantFiled: September 4, 2014Date of Patent: March 22, 2016Assignee: Pacific Biosciences of California, Inc.Inventors: Nathaniel Joseph McCaffrey, Stephen Turner, Ravi Saxena, Scott Edward Helgesen
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Publication number: 20160069806Abstract: An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device. The illumination may be received from a top, a side edge, and a bottom of the device. The waveguide assembly may include a nanoscale aperture disposed in the substrate and extending through the cladding. The aperture defines a reaction cell for receiving a set of reactants. In various aspects, the device includes a sensor element and the illumination pathway is through the sensor element. Waveguides and illumination devices, such as plasmonic illumination devices, are also disclosed. Methods for forming and operating the devices are also disclosed.Type: ApplicationFiled: September 3, 2015Publication date: March 10, 2016Applicant: Pacific Biosciences of California, Inc.Inventors: Adrian FEHR, Nathaniel Joseph McCaffrey, Stephen TURNER
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Publication number: 20150376694Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.Type: ApplicationFiled: June 4, 2015Publication date: December 31, 2015Applicant: Pacific Biosciences of California, Inc.Inventors: Nathaniel Joseph McCAFFREY, Stephen TURNER, Ravi SAXENA, Scott Edward HELGESEN
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Patent number: 9157864Abstract: An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device. The illumination may be received from a top, a side edge, and a bottom of the device. The waveguide assembly may include a nanoscale aperture disposed in the substrate and extending through the cladding. The aperture defines a reaction cell for receiving a set of reactants. In various aspects, the device includes a sensor element and the illumination pathway is through the sensor element. Waveguides and illumination devices, such as plasmonic illumination devices, are also disclosed. Methods for forming and operating the devices are also disclosed.Type: GrantFiled: May 16, 2013Date of Patent: October 13, 2015Assignee: Pacific Biosciences of California, Inc.Inventors: Adrian Fehr, Nathaniel Joseph McCaffrey, Stephen Turner
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Publication number: 20150247800Abstract: Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.Type: ApplicationFiled: March 9, 2015Publication date: September 3, 2015Inventors: Adrian FEHR, Nathaniel Joseph McCAFFREY, Stephen TURNER