Patents by Inventor Nathaniel Joseph McCaffrey

Nathaniel Joseph McCaffrey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10138515
    Abstract: An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device. The illumination may be received from a top, a side edge, and a bottom of the device. The waveguide assembly may include a nanoscale aperture disposed in the substrate and extending through the cladding. The aperture defines a reaction cell for receiving a set of reactants. In various aspects, the device includes a sensor element and the illumination pathway is through the sensor element. Waveguides and illumination devices, such as plasmonic illumination devices, are also disclosed. Methods for forming and operating the devices are also disclosed.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: November 27, 2018
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Adrian Fehr, Nathaniel Joseph McCaffrey, Stephen Turner
  • Publication number: 20180155781
    Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.
    Type: Application
    Filed: October 17, 2017
    Publication date: June 7, 2018
    Inventors: Nathaniel Joseph MCCAFFREY, Stephen TURNER, Ravi SAXENA, JR., Scott Edward HELGESEN
  • Patent number: 9822410
    Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.
    Type: Grant
    Filed: September 21, 2016
    Date of Patent: November 21, 2017
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Nathaniel Joseph McCaffrey, Stephen Turner, Ravi Saxena, Sr., Scott Edward Helgesen
  • Publication number: 20170137877
    Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.
    Type: Application
    Filed: September 21, 2016
    Publication date: May 18, 2017
    Inventors: Nathaniel Joseph MCCAFFREY, Stephen TURNER, Ravi SAXENA, SR., Scott Edward HELGESEN
  • Publication number: 20170030834
    Abstract: Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.
    Type: Application
    Filed: June 28, 2016
    Publication date: February 2, 2017
    Inventors: Adrian FEHR, Nathaniel Joseph MCCAFFREY, Stephen TURNER
  • Patent number: 9488584
    Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: November 8, 2016
    Assignee: Pacific Bioscience of California, Inc.
    Inventors: Nathaniel Joseph McCaffrey, Stephen Turner, Ravi Saxena, Scott Edward Helgesen
  • Patent number: 9410891
    Abstract: Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: August 9, 2016
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Adrian Fehr, Nathaniel Joseph McCaffrey, Stephen Turner
  • Patent number: 9291569
    Abstract: Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.
    Type: Grant
    Filed: March 9, 2015
    Date of Patent: March 22, 2016
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Adrian Fehr, Nathaniel Joseph McCaffrey, Stephen Turner
  • Patent number: 9291568
    Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.
    Type: Grant
    Filed: September 4, 2014
    Date of Patent: March 22, 2016
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Nathaniel Joseph McCaffrey, Stephen Turner, Ravi Saxena, Scott Edward Helgesen
  • Publication number: 20160069806
    Abstract: An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device. The illumination may be received from a top, a side edge, and a bottom of the device. The waveguide assembly may include a nanoscale aperture disposed in the substrate and extending through the cladding. The aperture defines a reaction cell for receiving a set of reactants. In various aspects, the device includes a sensor element and the illumination pathway is through the sensor element. Waveguides and illumination devices, such as plasmonic illumination devices, are also disclosed. Methods for forming and operating the devices are also disclosed.
    Type: Application
    Filed: September 3, 2015
    Publication date: March 10, 2016
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: Adrian FEHR, Nathaniel Joseph McCaffrey, Stephen TURNER
  • Publication number: 20150376694
    Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.
    Type: Application
    Filed: June 4, 2015
    Publication date: December 31, 2015
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: Nathaniel Joseph McCAFFREY, Stephen TURNER, Ravi SAXENA, Scott Edward HELGESEN
  • Patent number: 9157864
    Abstract: An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device. The illumination may be received from a top, a side edge, and a bottom of the device. The waveguide assembly may include a nanoscale aperture disposed in the substrate and extending through the cladding. The aperture defines a reaction cell for receiving a set of reactants. In various aspects, the device includes a sensor element and the illumination pathway is through the sensor element. Waveguides and illumination devices, such as plasmonic illumination devices, are also disclosed. Methods for forming and operating the devices are also disclosed.
    Type: Grant
    Filed: May 16, 2013
    Date of Patent: October 13, 2015
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Adrian Fehr, Nathaniel Joseph McCaffrey, Stephen Turner
  • Publication number: 20150247800
    Abstract: Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.
    Type: Application
    Filed: March 9, 2015
    Publication date: September 3, 2015
    Inventors: Adrian FEHR, Nathaniel Joseph McCAFFREY, Stephen TURNER
  • Patent number: 9075019
    Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.
    Type: Grant
    Filed: September 4, 2014
    Date of Patent: July 7, 2015
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Nathaniel Joseph McCaffrey, Stephen Turner, Ravi Saxena, Scott Edward Helgesen
  • Patent number: 8994946
    Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: March 31, 2015
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Nathaniel Joseph McCaffrey, Stephen Turner, Ravi Saxena
  • Publication number: 20150057194
    Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.
    Type: Application
    Filed: September 4, 2014
    Publication date: February 26, 2015
    Inventors: Nathaniel Joseph McCAFFREY, Stephen TURNER, Ravi SAXENA, Scott Edward HELGESEN
  • Patent number: 8867038
    Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: October 21, 2014
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Nathaniel Joseph McCaffrey, Stephen Turner, Ravi Saxena, Scott Edward Helgesen
  • Publication number: 20140171331
    Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.
    Type: Application
    Filed: December 16, 2013
    Publication date: June 19, 2014
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: Nathaniel Joseph McCaffrey, Stephen Turner, Ravi Saxena, Scott Edward Helgesen
  • Patent number: 8649011
    Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.
    Type: Grant
    Filed: May 16, 2013
    Date of Patent: February 11, 2014
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Nathaniel Joseph McCaffrey, Stephen Turner, Ravi Saxena, Scott Edward Helgesen
  • Publication number: 20130330731
    Abstract: An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device. The illumination may be received from a top, a side edge, and a bottom of the device. The waveguide assembly may include a nanoscale aperture disposed in the substrate and extending through the cladding. The aperture defines a reaction cell for receiving a set of reactants. In various aspects, the device includes a sensor element and the illumination pathway is through the sensor element. Waveguides and illumination devices, such as plasmonic illumination devices, are also disclosed. Methods for forming and operating the devices are also disclosed.
    Type: Application
    Filed: May 16, 2013
    Publication date: December 12, 2013
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: Adrian FEHR, Nathaniel Joseph McCaffrey, Stephen Turner