Abstract: The invention relates to luminescence-based compounds, compositions and methods for chemical sensing in solid state and solutions. More particularly, the invention includes “turn-on” lanthanide sensors that luminesce only in the presence of an organic compound (analyte) and are non-emissive in the absence of the organic compound (analyte).

Abstract: This disclosure related to modular and programmable peptide-oligonucleotide chimeras comprising of peptide and oligonucleotide segments interlinked by an organic core are presented and their assembly as morphologically-tunable soft materials, for example, nanostructure compositions comprising a plurality of compounds comprising a peptide segment and an oligonucleotide segment interlinked by an organic core moiety.

Abstract: Described herein are metal nanoparticle superstructures and methods and compounds for making the same.

Abstract: An approach to synthesizing and assembling nanoparticles into discrete, size-tunable, pre-designed architectures is realized in a single synthetic/process step.

Abstract: Materials and methods for regulating gene expression using nanoparticles functionalized with antisense oligonucleotides are provided.

Abstract: This disclosure related to modular and programmable peptide-oligonucleotide chimeras comprising of peptide and oligonucleotide segments interlinked by an organic core are presented and their assembly as morphologically-tunable soft materials, for example, nanostructure compositions comprising a plurality of compounds comprising a peptide segment and an oligonucleotide segment interlinked by an organic core moiety.

Abstract: Materials and methods for regulating gene expression using nanoparticles functionalized with antisense oligonucleotides are provided.

Abstract: Described herein are metal nanoparticle superstructures and methods and compounds for making the same.

Abstract: Materials and methods for regulating gene expression using nanoparticles functionalized with antisense oligonucleotides are provided.

Abstract: Mixed Matrix Membrane (MMM) are composite membranes for gas separation and comprising a quantity of inorganic filler particles, in particular metal organic framework (MOF), dispersed throughout a polymer matrix comprising one or more polymers. This disclosure is directed to MOF functionalized through addition of a pendant functional group to the MOF, in order to improve interaction with a surrounding polymer matrix in a MMM. The improved interaction aids in avoiding defects in the MMM due to incompatible interfaces between the polymer matrix and the MOF particle, in turn increasing the mechanical and gas separation properties of the MMM. The disclosure is also directed to a MMM incorporating the surface functionalized MOF.

Abstract: An approach to synthesizing and assembling nanoparticles into discrete, size-tunable, pre-designed architectures is realized in a single synthetic/process step.

Abstract: An approach to synthesizing and assembling nanoparticles into discrete, size-tunable, pre-designed architectures is realized in a single synthetic/process step.

Abstract: Materials and methods for regulating gene expression using nanoparticles functionalized with antisense oligonucleotides are provided.

Abstract: Materials and methods for regulating gene expression using nanoparticles functionalized with antisense oligonucleotides are provided.

Abstract: Metal-organic frameworks (MOFs) are crystalline porous materials that include metal ions linked together into periodic structures via organic ligands. MOFs that contain lanthanide ions are a new class of visible and near-IR luminescent materials, suitable for a broad range of applications. For example, the MOF framework afforded by 2,5-dimethoxy-1,4-phenylene)di-2,1-ethenediyl]bis-carboxylate is associated with unusually long luminescence lifetimes. Thus, a complex of this ligand with a lanthanide provides a sharp emission profile, coupled with a comparatively long signal lifetime, for an unusually high luminescence. More generally, lanthanide-MOF systems exhibit several advantages that are ideal for barcoded materials, due to the photophysical attributes of lanthanide cations and the well-defined organization of the MOF structure.

Abstract: Materials and methods for regulating gene expression using nanoparticles functionalized with antisense oligonucleotides are provided.

Abstract: Materials and methods for regulating gene expression using nanoparticles functionalized with antisense oligonucleotides are provided.

Abstract: Metal-organic frameworks (MOFs) are crystalline porous materials that include metal ions linked together into periodic structures via organic ligands. MOFs that contain lanthanide ions are a new class of visible and near-IR luminescent materials, suitable for a broad range of applications. For example, the MOF framework afforded by 2,5-dimethoxy-1,4-phenylene)di-2,1-ethenediyl]bis-carboxylate is associated with unusually long luminescence lifetimes. Thus, a complex of this ligand with a lanthanide provides a sharp emission profile, coupled with a comparatively long signal lifetime, for an unusually high luminescence. More generally, lanthanide-MOF systems exhibit several advantages that are ideal for barcoded materials, due to the photophysical attributes of lanthanide cations and the well-defined organization of the MOF structure.

Abstract: Disclosed herein are asymmetrically functionalized nanoparticles. Further disclosed herein are methods of preparing asymmetrically functionalized nanoparticles. Asymmetrically functionalized nanoparticles can be used in various therapeutic methods.

Abstract: Materials and methods for regulating gene expression using nanoparticles functionalized with antisense oligonucleotides are provided.