Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.

Abstract: This invention establishes a new paradigm for treatment of Parkinson's disease (PD) by eliminating senescent cells that reside in or around the site of the disease pathophysiology. Exposure of test subjects to the herbicide paraquat (PQ) increases the risk for developing Parkinson's disease. The data in this disclosure show that PQ induces a senescence arrest and SASP in astrocytes, in culture and in vivo in mice, and senescent cell markers were present in astrocytes in midbrain tissue from PD patients. In a transgenic mouse model, senescent cell ablation protected against PQ-induced PD-like neuropathology. Removal of senescent cells from affected sites using small molecule agents that specifically target senescent cells can help prevent or ameliorate signs and symptoms of the disease.

Abstract: Techniques for managing network-accessible infrastructure metadata are provided. A method includes receiving a resource request comprising resource metadata corresponding to a network-accessible infrastructure resource, determining whether to commit the resource request based at least in part on a constraint associated with the network-accessible infrastructure resource, and, in accordance with a determination to commit the resource request: generating, by the computer system, a resource identifier describing resource metadata in accordance with the resource request, storing, by the computer system, the resource metadata in a data store in communication with the computer system, receiving, by the computer system, a data request to provide the resource metadata described by the resource identifier, and providing, by the computer system, the resource metadata described by the resource identifier in accordance with the data request.

Abstract: Provided are systems and methods for producing seamless woven materials that are variable in each of their 3 dimensions. The systems and methods generally operate by altering heddle positions independently to impart three dimensional structure to a woven fabric. Weft yarn is woven into a set of warp yarns that have been individually raised or lowered along a particular cross section, essentially locking the weave into an intended 3 dimensional form.

Abstract: Described are compositions and methods relate to stable, high-payload, non-porous enzyme-containing coated granules with improved resistance to activity loss during steam pelleting.

Abstract: The system can include an on-board thermal management subsystem. The system 100 can optionally include an off-board (extravehicular) infrastructure subsystem. The on-board thermal management subsystem can include: a battery pack, one or more fluid loops, and an air manifold. The system 100 can additionally or alternatively include any other suitable components.

Abstract: Techniques for implementing an infrastructure orchestration service are described. A configuration file for a deployment to a first execution target and a second execution target can be received. A first safety plan can be generated for the first execution target that comprises a first list of resources and operations associated with deployment at the first execution target. Approval of the first safety plan can be received. A second safety plan can be generated for the second execution target that comprises a second list of resources and operations associated with deployment at the second execution target. A determination can be made whether the second safety plan is a subset of the first safety plan. If the determination is that the second safety plan is a subset of the first safety plan, the second safety plan can automatically be approved and transmitted to the second execution target for deployment.

Abstract: Exemplary embodiments provide methods, mediums, and systems for comparing a sample of interest to a library of known compounds to quickly determine how similar the sample is to the compounds in the library. Peaks of interest in the sample data are compared to corresponding peaks in the library compound data. These peaks may be represented as vectors, and an angle between the sample vector and the library vector may be used as a similarity metric. In some embodiments, a cosine similarity may be calculated for the vectors. If the similarity score for a given library compound/sample pair exceed a threshold, then the system determines that the library compound and the sample are similar and takes appropriate action. Various parameters associated with the comparison can be adjusted in order to improve the quality of the results and/or the efficiency of the process.

Abstract: Techniques are disclosed for utilizing directed acyclic graphs for deployment instructions. A computer-implemented method can include various operations. Instructions may be executed by a computing device to perform parses of configuration data associated with deploying one or more services to various execution targets. The computing device may cause a first graph to be generated that indicates dependencies between tasks associated with deploying the service(s). A second graph may be generated that specifies dependencies between different deployments of the service(s) to the execution target(s). Services may be deployed based on traversing the first and second graph.

Abstract: Described herein are systems and methods for the management and control of electrolyte within confined electrochemical cells or groups (e.g. stacks) of connected electrochemical cells, for example, in an electrolyzer. Various embodiments of systems and methods provide for the elimination of parasitic conductive paths between cells, and/or precise passive control of fluid pressures within cells. In some embodiments, a fixed volume of electrolyte is substantially retained within each cell while efficiently collecting and removing produced gases or other products from the cell.

Abstract: Techniques for implementing an infrastructure orchestration service are described. A configuration file for a deployment to a first execution target and a second execution target can be received. A first safety plan can be generated for the first execution target that comprises a first list of resources and operations associated with deployment at the first execution target. Approval of the first safety plan can be received. A second safety plan can be generated for the second execution target that comprises a second list of resources and operations associated with deployment at the second execution target. A determination can be made whether the second safety plan is a subset of the first safety plan. If the determination is that the second safety plan is a subset of the first safety plan, the second safety plan can automatically be approved and transmitted to the second execution target for deployment.

Abstract: Techniques for implementing an infrastructure orchestration service are described. A safety plan comprising a list of resources and operations based at least in part on a deployment configuration file can be received. Upon receiving approval of the safety plan, an operation corresponding to at least one of the list of resources can be prepared to be performed. The operation can be compared to the safety plan. If the operation is part of the safety plan, the operation can be performed. If the operation is not part of the safety plan, the deployment can be halted, and a notification that the deployment is not in compliance with the safety plan can be transmitted.

Abstract: The system can include an on-board thermal management subsystem. The system 100 can optionally include an off-board (extravehicular) infrastructure subsystem. The on-board thermal management subsystem can include: a battery pack, one or more fluid loops, and an air manifold. The system 100 can additionally or alternatively include any other suitable components.

Abstract: A cloud-based security solution that provides a robust and secure framework for managing and enforcing security policies related to various resources managed in the cloud is disclosed. The cloud-based security solution is implemented by a security zone policy enforcement system in a cloud service provider infrastructure. The system receives a request to perform an operation on a resource and determines a compartment associated with the resource. The system determines that the compartment is associated with a security zone and determines a set of one or more security zone policies applicable to the resource. The system then determines that the operation on the resource is permitted based on the set of one or more security zone policies and responsive to determining that the operation on the resource is permitted, allows the operation to be performed on the resource.

Abstract: Techniques are disclosed for managing dependencies in an orchestration service. A computer-implemented method can include operations performed by a declarative infrastructure provisioner (DIP). In some embodiments, the DIP parses configuration data associated with a computing system and generates a directed acyclic graph (DAG) for booting a first resource. The DAG may specify a dependency of the first resource on a capability of a second resource. The DIP may traverse the DAG and determine, based at least in part on the traversal, that the dependency has been reached. The DIP may publish, to a scheduling process, an indication that the first resource is awaiting availability of the capability of the second resource. In some embodiments, the DIP receives a subsequent indication that the capability is available, regenerates the DAG, and recommences traversal of the DAG. Additional operations for booting the first resource may be performed in accordance with the recommenced traversal.

Abstract: Techniques and apparatus for information assessment processes are described. In one embodiment, for example, a computer-implemented method for performing a review-by-exception process may include, via one or more processors of a computing device, accessing chromatography information generated via analyzing a sample using a mass spectrometry system, the chromatography information comprising at least one peak and at least one peak attribute for the at least one peak, determining posterior probability information for the chromatography information; generating an estimated peak model based on the posterior probability information, determining a confidence indicator for the estimated peak model, and generating an exception for the at least one peak responsive to the confidence indicator being outside of an exception threshold. Other embodiments are described.

Abstract: Techniques are disclosed for managing dependencies in an orchestration service. A computer-implemented method can include operations performed by a declarative infrastructure provisioner (DIP). In some embodiments, the DIP parses configuration data associated with a computing system and generates a directed acyclic graph (DAG) for booting a first resource. The DAG may specify a dependency of the first resource on a capability of a second resource. The DIP may traverse the DAG and determine, based at least in part on the traversal, that the dependency has been reached. The DIP may publish, to a scheduling process, an indication that the first resource is awaiting availability of the capability of the second resource. In some embodiments, the DIP receives a subsequent indication that the capability is available, regenerates the DAG, and recommences traversal of the DAG. Additional operations for booting the first resource may be performed in accordance with the recommenced traversal.

Abstract: Techniques for preventing concurrent execution of an infrastructure orchestration service are described. Worker nodes can receive instructions, or tasks, for deploying infrastructure resources and can provide heartbeat notifications to scheduler nodes, also considered a lease. A signing proxy can track the heartbeat notifications sent from the worker nodes to the scheduler node. The signing proxy can receive requests corresponding to a performance of the tasks assigned to the worker nodes. The signing proxy can determine whether the lease between each worker node and the scheduler is valid. If the lease is valid, the signing proxy may make a call to services on behalf of the worker node, and if the lease is not valid, the signing proxy may not make a call to services on behalf of the worker node. Instead, the signing proxy may cut off all outgoing network traffic, blocking access of the worker node to services.

Abstract: Techniques for implementing an infrastructure orchestration service are described. In some examples, a declarative provisioner of the infrastructure orchestration service receives instructions for deployment of a resource. The declarative provisioner identifies that the deployment of the resource is a long-running task stores state information corresponding to the deployment of the resource. In certain embodiments, upon identifying that the deployment of the resource is a long-running task, the declarative provisioner pauses its execution of the long-running task. Responsive to a trigger received from the infrastructure orchestration service, the declarative provisioner resumes execution of the deployment of the resource using the state information and transmits deployment information corresponding to the deployment of the resource to the infrastructure orchestration service.