Abstract: Centralized artifacts systems and methods for processing artifacts of distributed entities are disclosed. The centralized artifacts system receives a set of artifact-input data associated with the artifacts of the distributed entities. An artifact suggestions generator can generate artifact hierarchies using the artifact-input data. Artifact hierarchies can include categorical containers, tile elements, artifact fields, and suggested task blocks. An artifact collection interface can display the artifact hierarchies to entities and receive, from the entities, a new set of artifact-input data associated with the completion of the artifact hierarchies. Using the new set of artifact-input data, the centralized artifacts system performs updates to the artifact hierarchies such as modifying the existing artifact hierarchies or generating new artifact hierarchies.

Abstract: The present invention provides, among other things, antibody agents (e.g., antibodies, and/or antigen-binding fragments thereof) that bind to DV epitopes, as well as compositions containing them and methods of designing, providing, formulating, using, identifying and/or characterizing them. In some embodiments, provided antibody agents show significant binding to a plurality of DV serotypes. In some embodiments, provided antibody agents show significant binding to all four DV serotypes. Such antibody agents are useful, for example, in the prophylaxis, treatment, diagnosis, and/or study of DV.

Abstract: An electrostatic clamp monitoring system has an electrostatic clamp configured to selectively electrostatically clamp a workpiece to a clamping surface via one or more electrodes. A power supply electrically coupled to the electrostatic clamp is configured to selectively supply a clamping voltage to the one or more electrodes. A data acquisition system is coupled to the power supply and configured to measure a current supplied to the one or more electrodes, therein defining a measured current. A controller integrates the measured current over time, therein determining a charge value associated a clamping force between the workpiece and electrostatic clamp. A memory stores the charge value associated with the clamping force over a plurality of clamping cycles, therein defining a plurality of charge values, and the controller determines a clamping capability of the electrostatic clamp based on a comparison of a currently determined charge value to the plurality of charge values.

Abstract: The invention includes compositions and methods for treating or preventing a cancer in a subject. In one aspect the invention provides methods of administering to a subject suffering from a cancer with cells containing an IDH1 or IDH2 mutation, at least one compound comprising a DNA repair inhibitor. The invention also provides methods of treating a cancer with 2 HG, a derivative of 2-HG, any variant and any mixtures thereof. In one aspect the invention provides a pharmaceutical composition comprising an anti-tumor effective mount of at least one compound selected from the group consisting of 2-hydroxyglutarate (2-HG), a derivative of 2-HG, any variant and any mixtures thereof.

Abstract: The present invention provides, among other things, antibody agents (e.g., antibodies, and/or antigen-binding fragments thereof) that bind to DV epitopes, as well as compositions containing them and methods of designing, providing, formulating, using, identifying and/or characterizing them. In some embodiments, provided antibody agents show significant binding to a plurality of DV serotypes. In some embodiments, provided antibody agents show significant binding to all four DV serotypes. Such antibody agents are useful, for example, in the prophylaxis, treatment, diagnosis, and/or study of DV.

Abstract: The present invention provides, among other things, antibody agents (e.g., antibodies, and/or antigen-binding fragments thereof) that bind to DV epitopes, as well as compositions containing them and methods of designing, providing, formulating, using, identifying and/or characterizing them. In some embodiments, provided antibody agents show significant binding to a plurality of DV serotypes. In some embodiments, provided antibody agents show significant binding to all four DV serotypes. Such antibody agents are useful, for example, in the prophylaxis, treatment, diagnosis, and/or study of DV.

Abstract: The present invention provides, among other things, antibody agents (e.g., antibodies, and/or antigen-binding fragments thereof) that bind to DV epitopes, as well as compositions containing them and methods of designing, providing, formulating, using, identifying and/or characterizing them. In some embodiments, provided antibody agents show significant binding to a plurality of DV serotypes. In some embodiments, provided antibody agents show significant binding to all four DV serotypes. Such antibody agents are useful, for example, in the prophylaxis, treatment, diagnosis, and/or study of DV.

Abstract: The present invention provides, among other things, antibody agents (e.g., antibodies, and/or antigen-binding fragments thereof) that bind to DV epitopes, as well as compositions containing them and methods of designing, providing, formulating, using, identifying and/or characterizing them. In some embodiments, provided antibody agents show significant binding to a plurality of DV serotypes. In some embodiments, provided antibody agents show significant binding to all four DV serotypes. Such antibody agents are useful, for example, in the prophylaxis, treatment, diagnosis, and/or study of DV.

Abstract: The present invention provides, among other things, antibody agents (e.g., antibodies, and/or antigen-binding fragments thereof) that bind to DV epitopes, as well as compositions containing them and methods of designing, providing, formulating, using, identifying and/or characterizing them. In some embodiments, provided antibody agents show significant binding to a plurality of DV serotypes. In some embodiments, provided antibody agents show significant binding to all four DV serotypes. Such antibody agents are useful, for example, in the prophylaxis, treatment, diagnosis, and/or study of DV.

Abstract: The present invention relates to a wettability switch that comprises an electrochemically active element having a wetting surface with switchable wetting properties. The electrochemically active element comprises an electrochemically active polymer, and surface active molecules each having a lyophobic portion and a lyophilic portion. In the wettability switch, each of said surface active molecules exposes one of said lyophobic portion and said lyophilic portion towards said wetting surface, and the identity of said portion depends on an electrochemical state of said polymer.

Abstract: A fast organic field effect transistor (100), which operates at low voltages, is achieved by the introduction of an oligomeric or polymeric electrolyte (131) between the gate electrode (141) and the organic semiconductor layer (121), which electrolyte (131) has a dissociation constant of at least 10?8. Said organic semiconductor layer (121) is in contact with the source electrode (111) and the drain electrode (112) of the transistor. In operation a potential (152) applied to said gate electrode (141) controls the current A between said source electrode (111) and said drain electrode (112).

Abstract: The present invention provides an electrochemical timer device (110) having a source (101) and a drain (102) contact. The device further comprises a switch channel (104) and a delay reservoir (103) that are electrochemically interconnected with a gate electrode (105). The switch channel (104) interconnects the source (101) and drain (102) contacts and is arranged to change electrical conductivity upon electrochemistry therein, and an electrochemical reaction is arranged to occur in the gate electrode (105) and delay reservoir (103) upon application of a drive voltage there between. The delay reservoir (103) is arranged such that the electrochemical reaction occurring therein gradually moves towards the switch channel (104) and eventually reaches the switch channel (104) after a delay time thereby changing the electrical conductivity of the switch channel (104).

Abstract: The present invention relates to a wettability switch that comprises an electrochemically active element having a wetting surface with switchable wetting properties. The electrochemically active element comprises an electrochemically active polymer, and surface active molecules each having a lyophobic portion and a lyophilic portion. In the wettability switch, each of said surface active molecules exposes one of said lyophobic portion and said lyophilic portion towards said wetting surface, and the identity of said portion depends on an electrochemical state of said polymer.

Abstract: A device is disclosed for electrically controlled transport of ions between a source and a target electrolyte, including a source electrode and a target electrode. The electrodes are each capable of conducting ions, and the source electrode is arranged to receive ions from the source electrolyte and the target electrode is arranged to release ions to the target electrolyte. The device further includes an ion-conductive channel, arranged to receive ions from the source electrode and to release ions to the target electrode. Moreover, the ion-conductive channel is arranged to provide an ionic connection between the source and the target electrodes. The electrodes and the ion-conductive channel are formed of solid or semi-solid materials which are directly or indirectly attached to a support.

Abstract: A device for determining a parameter history indication of at least one external parameter, comprises an electrode, termed “first electrode” (2, 2a, 2b, 2c), and another electrode, termed “third electrode” (4, 4a, 4b, 4c). The electrodes (2, 2a, 2b, 2c; 4, 4a, 4b, 4c) are in consuming contact with a respective electrolyte (5, 6, 6a, 6b, 6c). A consumption process of the third electrode is controllable by an amount of consumption of said first electrode. The electrolytes are so arranged that consumption rates of the first and third electrodes (2, 2a, 2b, 2c; 4, 4a, 4b, 4c) present different dependencies on the at least one external parameter. A kit of parts including such a device, and a method for determining a parameter history indication of at least one external parameter are also disclosed.

Abstract: A fast organic field effect transistor (100), which operates at low voltages, is achieved by the introduction of an oligomeric or polymeric electrolyte (131) between the gate electrode (141) and the organic semiconductor layer (121), which electrolyte (131) has a dissociation constant of at least 10?8. Said organic semiconductor layer (121) is in contact with the source electrode (111) and the drain electrode (112) of the transistor. In operation a potential (152) applied to said gate electrode (141) controls the current A between said source electrode (111) and said drain electrode (112).

Abstract: The present invention provides an electrochemical timer device (110) having a source (101) and a drain (102) contact. The device further comprises a switch channel (104) and a delay reservoir (103) that are electrochemically interconnected with a gate electrode (105). The switch channel (104) interconnects the source (101) and drain (102) contacts and is arranged to change electrical conductivity upon electrochemistry therein, and an electrochemical reaction is arranged to occur in the gate electrode (105) and delay reservoir (103) upon application of a drive voltage there between. The delay reservoir (103) is arranged such that the electrochemical reaction occurring therein gradually moves towards the switch channel (104) and eventually reaches the switch channel (104) after a delay time thereby changing the electrical conductivity of the switch channel (104).

Abstract: The present invention provides a sensor device for measuring an electric field in a charge carrying medium. To this end, the sensor device defines a sensor space that is arranged to receive the charge carrying medium, and that comprises terminals for applying an electric field across the sensor space. Furthermore, sensor elements are arranged spatially separated in the sensor space. The sensor elements are operable to perform electrochemistry in response to the electric field and to change optical appearance upon said electrochemistry. Thereby electric field present in said sensor space is detectable from an optical appearance of said sensor elements.

Abstract: A spacer for use with a protective grid of a fuel assembly of a nuclear reactor is a generally washer-shaped plate of material having an engagement surface and a retention surface opposite one another. The protective grid is formed of a plurality of straps to define a plurality of fuel rod cells and a plurality of thimble cells, with the straps adjacent the thimble cells being notched to receive the spacer therein. The retention surface of the spacer is disposed against the notches, and the engagement surface of the spacer protrudes outwardly from the protective grid. When the engagement surfaces of the spacers are engaged against a lower nozzle of a fuel assembly of a nuclear reactor, the spacers space the protective grid from the lower nozzle. The spacer is integrally welded with the protective grid in a single arranging and welding operation.

Abstract: A spacer for use with a protective grid of a fuel assembly of a nuclear reactor is a generally washer-shaped plate of material having an engagement surface and a retention surface opposite one another. The protective grid is formed of a plurality of straps to define a plurality of fuel rod cells and a plurality of thimble cells, with the straps adjacent the thimble cells being notched to receive the spacer therein. The retention surface of the spacer is disposed against the notches, and the engagement surface of the spacer protrudes outwardly from the protective grid. When the engagement surfaces of the spacers are engaged against a lower nozzle of a fuel assembly of a nuclear reactor, the spacers space the protective grid from the lower nozzle. The spacer is integrally welded with the protective grid in a single arranging and welding operation.