Patents by Inventor Nathaniel Roquet
Nathaniel Roquet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230036568Abstract: Systems and methods are provided herein for encoding and storing information in nucleic acids. Encoded information is partitioned and stored in nucleic acids having native key-value pairs that allow for storage of metadata or other data objects. Computation on the encoded information is performed by chemical implementation of if-then-else operations. Numerical data is stored in nucleic acids by producing samples having nucleic acid sequences copy counts corresponding to the numerical data. Data objects of a dataset are encoded by partitioning of bytes into parts and encoding of parts along distinct libraries of nucleic acids. These libraries can be used as inputs for computation on the dataset.Type: ApplicationFiled: March 14, 2022Publication date: February 2, 2023Inventors: Nathaniel Roquet, Swapnil P. Bhatia, Michael Norsworthy, Sarah Flickinger, Tracy Kambara
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Publication number: 20230026655Abstract: The present disclosure discloses methods and systems for encoding digital information in nucleic acid (e.g., deoxyribonucleic acid) molecules without base-by-base synthesis, by encoding bit-value information in the presence or absence of unique nucleic acid sequences within a pool, comprising specifying each bit location in a bit-stream with a unique nucleic sequence and specifying the bit value at that location by the presence or absence of the corresponding unique nucleic acid sequence in the pool. Also disclosed are chemical methods for generating unique nucleic acid sequences using combinatorial genomic strategies (e.g., assembly of multiple nucleic acid sequences or enzymatic-based editing of nucleic acid sequences).Type: ApplicationFiled: February 17, 2022Publication date: January 26, 2023Inventors: Devin Leake, Milena Lazova, Sarah Flickinger, Nathaniel Roquet, Hyunjun Park, Swapnil P. Bhatia
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Patent number: 11535842Abstract: Methods and systems for security, authentication, tagging, and tracking using nucleic acid (e.g., deoxyribonucleic acid) molecules encoding information. Unique nucleic acid molecules are efficiently produced from pre-fabricated fragments to quickly produce libraries of nucleic acid molecules encoding encrypted or randomized information. Physical objects or artifacts can be tagged with libraries to authenticate the objects, grant access to secured assets or locations, or track the objects or entities. Chemical methods can be applied to verify authenticity, decrypt, or decode information stored in the libraries.Type: GrantFiled: October 13, 2020Date of Patent: December 27, 2022Assignee: CATALOG TECHNOLOGIES, INC.Inventors: Nathaniel Roquet, Hyunjun Park, Swapnil P. Bhatia, Devin Leake
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Patent number: 11379729Abstract: Methods and systems for encoding digital information in nucleic acid (e.g., deoxyribonucleic acid) molecules without base-by-base synthesis, by encoding bit-value information in the presence or absence of unique nucleic acid sequences within a pool, comprising specifying each bit location in a bit-stream with a unique nucleic sequence and specifying the bit value at that location by the presence or absence of the corresponding unique nucleic acid sequence in the pool But, more generally, specifying unique bytes in a bytestream by unique subsets of nucleic acid sequences. Also disclosed are methods for generating unique nucleic acid sequences without base-by-base synthesis using combinatorial genomic strategies (e.g., assembly of multiple nucleic acid sequences or enzymatic-based editing of nucleic acid sequences).Type: GrantFiled: August 31, 2020Date of Patent: July 5, 2022Assignee: CATALOG TECHNOLOGIES, INC.Inventors: Nathaniel Roquet, Hyunjun Park, Swapnil P. Bhatia
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Patent number: 11306353Abstract: Systems and methods are provided herein for encoding and storing information in nucleic acids. Encoded information is partitioned and stored in nucleic acids having native key-value pairs that allow for storage of metadata or other data objects. Computation on the encoded information is performed by chemical implementation of if-then-else operations. Numerical data is stored in nucleic acids by producing samples having nucleic acid sequences copy counts corresponding to the numerical data. Data objects of a dataset are encoded by partitioning of bytes into parts and encoding of parts along distinct libraries of nucleic acids. These libraries can be used as inputs for computation on the dataset.Type: GrantFiled: May 11, 2021Date of Patent: April 19, 2022Assignee: CATALOG TECHNOLOGIES, INC.Inventors: Nathaniel Roquet, Swapnil P. Bhatia, Michael Norsworthy, Sarah Flickinger, Tracy Kambara
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Patent number: 11305527Abstract: Provided herein are systems and methods for storing digital information by assembling an identifier nucleic acid molecule from at least a first component nucleic acid molecule and a second component nucleic acid molecule. The system may include a first printhead configured to dispense a first droplet of a first solution comprising the first component nucleic acid molecule onto a coordinate on a substrate, and a second printhead configured to dispense a second droplet of a second solution comprising the second component nucleic acid molecule onto the coordinate on the substrate, such that the first and second component nucleic acid molecules are collocated on the substrate. The system may include a finisher that dispenses a reaction mix onto the coordinate on the substrate to physically link the first and second component nucleic acid molecules, provides a condition necessary to physically link the first and second component nucleic acid molecules, or both.Type: GrantFiled: March 10, 2021Date of Patent: April 19, 2022Assignee: CATALOG TECHNOLOGIES, INC.Inventors: Nathaniel Roquet, Hyunjun Park, Swapnil P. Bhatia, Mike Hazell, Richard Day, Richard Hammond, James Brown, Rodney Richardson, Thomas Redman, Devin Leake
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Patent number: 11286479Abstract: The present disclosure discloses methods and systems for encoding digital information in nucleic acid (e.g., deoxyribonucleic acid) molecules without base-by-base synthesis, by encoding bit-value information in the presence or absence of unique nucleic acid sequences within a pool, comprising specifying each bit location in a bit-stream with a unique nucleic sequence and specifying the bit value at that location by the presence or absence of the corresponding unique nucleic acid sequence in the pool. Also disclosed are chemical methods for generating unique nucleic acid sequences using combinatorial genomic strategies (e.g., assembly of multiple nucleic acid sequences or enzymatic-based editing of nucleic acid sequences).Type: GrantFiled: September 4, 2020Date of Patent: March 29, 2022Assignee: CATALOG TECHNOLOGIES, INC.Inventors: Devin Leake, Milena Lazova, Sarah Flickinger, Nathaniel Roquet, Hyunjun Park, Swapnil P. Bhatia
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Patent number: 11227219Abstract: The present disclosure provides systems and methods for storing digital information into nucleic acid molecules in various ways. Digital information may be received as a sting of symbols, wherein each symbol in the string of symbols has a symbol value and a symbol position within the string of symbols. A first identifier nucleic acid molecule may be formed by depositing M selected component nucleic acid molecules into a compartment, the M selected component nucleic acid molecules being selected from a set of distinct component nucleic acid molecules that are separated into M different layers, and physically assembling the M selected component nucleic acid molecules. A plurality of identifier nucleic acid molecules may be formed, each corresponding to a respective symbol position. The identifier nucleic acid molecules may be formed in a pool having powder, liquid, or solid form.Type: GrantFiled: March 19, 2021Date of Patent: January 18, 2022Assignee: CATALOG TECHNOLOGIES, INC.Inventors: Nathaniel Roquet, Hyunjun Park, Swapnil P. Bhatia, Devin Leake
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Publication number: 20210348214Abstract: Systems and methods are provided herein for encoding and storing information in nucleic acids. Encoded information is partitioned and stored in nucleic acids having native key-value pairs that allow for storage of metadata or other data objects. Computation on the encoded information is performed by chemical implementation of if-then-else operations. Numerical data is stored in nucleic acids by producing samples having nucleic acid sequences copy counts corresponding to the numerical data. Data objects of a dataset are encoded by partitioning of bytes into parts and encoding of parts along distinct libraries of nucleic acids. These libraries can be used as inputs for computation on the dataset.Type: ApplicationFiled: May 11, 2021Publication date: November 11, 2021Inventors: Nathaniel Roquet, Swapnil P. Bhatia, Michael Norsworthy, Sarah Flickinger, Tracy Kambara
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Publication number: 20210209479Abstract: The present disclosure provides systems and methods for storing digital information into nucleic acid molecules in various ways. Digital information may be received as a sting of symbols, wherein each symbol in the string of symbols has a symbol value and a symbol position within the string of symbols. A first identifier nucleic acid molecule may be formed by depositing M selected component nucleic acid molecules into a compartment, the M selected component nucleic acid molecules being selected from a set of distinct component nucleic acid molecules that are separated into M different layers, and physically assembling the M selected component nucleic acid molecules. A plurality of identifier nucleic acid molecules may be formed, each corresponding to a respective symbol position. The identifier nucleic acid molecules may be formed in a pool having powder, liquid, or solid form.Type: ApplicationFiled: March 19, 2021Publication date: July 8, 2021Inventors: Nathaniel Roquet, Hyunjun Park, Swapnil P. Bhatia, Devin Leake
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Publication number: 20210210165Abstract: The systems, devices, and methods described herein provide scalable methods for writing data to and reading data from nucleic acid molecules. The present disclosure covers four primary areas of interest: (1) accurately and quickly reading information stored in nucleic acid molecules, (2) partitioning data to efficiently encode data in nucleic acid molecules, (3) error protection and correction when encoding data in nucleic acid molecules, and (4) data structures to provide efficient access to information stored in nucleic acid molecules.Type: ApplicationFiled: March 19, 2021Publication date: July 8, 2021Inventors: Devin Leake, Swapnil P. Bhatia, Hyunjun Park, Nathaniel Roquet, Graeme Doran
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Publication number: 20210187944Abstract: Provided herein are systems and methods for storing digital information by assembling an identifier nucleic acid molecule from at least a first component nucleic acid molecule and a second component nucleic acid molecule. The system may include a first printhead configured to dispense a first droplet of a first solution comprising the first component nucleic acid molecule onto a coordinate on a substrate, and a second printhead configured to dispense a second droplet of a second solution comprising the second component nucleic acid molecule onto the coordinate on the substrate, such that the first and second component nucleic acid molecules are collocated on the substrate. The system may include a finisher that dispenses a reaction mix onto the coordinate on the substrate to physically link the first and second component nucleic acid molecules, provides a condition necessary to physically link the first and second component nucleic acid molecules, or both.Type: ApplicationFiled: March 10, 2021Publication date: June 24, 2021Inventors: Nathaniel Roquet, Hyunjun Park, Swapnil P. Bhatia, Mike Hazell, Richard Day, Richard Hammond, James Brown, Rodney Richardson, Thomas Redman, Devin Leake
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Publication number: 20210108194Abstract: Methods and systems for security, authentication, tagging, and tracking using nucleic acid (e.g., deoxyribonucleic acid) molecules encoding information. Unique nucleic acid molecules are efficiently produced from pre-fabricated fragments to quickly produce libraries of nucleic acid molecules encoding encrypted or randomized information. Physical objects or artifacts can be tagged with libraries to authenticate the objects, grant access to secured assets or locations, or track the objects or entities. Chemical methods can be applied to verify authenticity, decrypt, or decode information stored in the libraries.Type: ApplicationFiled: October 13, 2020Publication date: April 15, 2021Inventors: Nathaniel Roquet, Hyunjun Park, Swapnil P. Bhatia, Devin Leake
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Publication number: 20210079382Abstract: The present disclosure discloses methods and systems for encoding digital information in nucleic acid (e.g., deoxyribonucleic acid) molecules without base-by-base synthesis, by encoding bit-value information in the presence or absence of unique nucleic acid sequences within a pool, comprising specifying each bit location in a bit-stream with a unique nucleic sequence and specifying the bit value at that location by the presence or absence of the corresponding unique nucleic acid sequence in the pool. Also disclosed are chemical methods for generating unique nucleic acid sequences using combinatorial genomic strategies (e.g., assembly of multiple nucleic acid sequences or enzymatic-based editing of nucleic acid sequences).Type: ApplicationFiled: September 4, 2020Publication date: March 18, 2021Inventors: Devin Leake, Milena Lazova, Sarah Flickinger, Nathaniel Roquet, Hyunjun Park, Swapnil P. Bhatia
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Publication number: 20200401903Abstract: Methods and systems for encoding digital information in nucleic acid (e.g., deoxyribonucleic acid) molecules without base-by-base synthesis, by encoding bit-value information in the presence or absence of unique nucleic acid sequences within a pool, comprising specifying each bit location in a bit-stream with a unique nucleic sequence and specifying the bit value at that location by the presence or absence of the corresponding unique nucleic acid sequence in the pool But, more generally, specifying unique bytes in a bytestream by unique subsets of nucleic acid sequences. Also disclosed are methods for generating unique nucleic acid sequences without base-by-base synthesis using combinatorial genomic strategies (e.g., assembly of multiple nucleic acid sequences or enzymatic-based editing of nucleic acid sequences).Type: ApplicationFiled: August 31, 2020Publication date: December 24, 2020Inventors: Nathaniel Roquet, Hyunjun Park, Swapnil P. Bhatia
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Publication number: 20200357483Abstract: The present disclosure is directed to enabling search and extraction of data stored in DNA with optimized data structures and functions. Accordingly, systems and methods are provided herein for performing certain functions on data stored in nucleic acid molecules. The present disclosure covers at least the following areas of interest: (1) data structures to provide efficient access and search of information stored in nucleic acid molecules, (2) accurate and quick reading of information stored in nucleic acid molecules, (3) targeted approaches to accessing subsets of information stored in nucleic acid molecules, (4) a rank function that determines a count of particular bit or symbol value in a set of information stored in nucleic acid molecules, (5) functions including counting, locating, and extracting occurrences of a specific pattern in a message of information stored in nucleic acid molecules, and (6) an if-then-else operation to sort data stored in nucleic acid molecules.Type: ApplicationFiled: May 11, 2020Publication date: November 12, 2020Inventors: Nathaniel Roquet, Swapnil P. Bhatia, Paolo Ferragina
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Publication number: 20200250546Abstract: Methods and systems for encoding digital information in nucleic acid (e.g., deoxyribonucleic acid) molecules without base-by-base synthesis, by encoding bit-value information in the presence or absence of unique nucleic acid sequences within a pool, comprising specifying each bit location in a bit-stream with a unique nucleic sequence and specifying the bit value at that location by the presence or absence of the corresponding unique nucleic acid sequence in the pool. But, more generally, specifying unique bytes in a bytestream by unique subsets of nucleic acid sequences. Also disclosed are methods for generating unique nucleic acid sequences without base-by-base synthesis using combinatorial genomic strategies (e.g., assembly of multiple nucleic acid sequences or enzymatic-based editing of nucleic acid sequences).Type: ApplicationFiled: April 13, 2020Publication date: August 6, 2020Inventors: Nathaniel Roquet, Hyunjun Park, Swapnil P. Bhatia
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Publication number: 20200193301Abstract: The present disclosure provides systems and methods for storing digital information into nucleic acid molecules in various ways. Digital information may be received as a sting of symbols, wherein each symbol in the string of symbols has a symbol value and a symbol position within the string of symbols. A first identifier nucleic acid molecule may be formed by depositing M selected component nucleic acid molecules into a compartment, the M selected component nucleic acid molecules being selected from a set of distinct component nucleic acid molecules that are separated into M different layers, and physically assembling the M selected component nucleic acid molecules. A plurality of identifier nucleic acid molecules may be formed, each corresponding to a respective symbol position. The identifier nucleic acid molecules may be formed in a pool having powder, liquid, or solid form.Type: ApplicationFiled: May 16, 2019Publication date: June 18, 2020Inventors: Nathaniel Roquet, Hyunjun Park, Swapnil P. Bhatia, Devin Leake
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Publication number: 20200185057Abstract: The systems, devices, and methods described herein provide scalable methods for writing data to and reading data from nucleic acid molecules. The present disclosure covers four primary areas of interest: (1) accurately and quickly reading information stored in nucleic acid molecules, (2) partitioning data to efficiently encode data in nucleic acid molecules, (3) error protection and correction when encoding data in nucleic acid molecules, and (4) data structures to provide efficient access to information stored in nucleic acid molecules.Type: ApplicationFiled: August 5, 2019Publication date: June 11, 2020Inventors: Devin Leake, Swapnil P. Bhatia, Hyunjun Park, Nathaniel Roquet, Graeme Doran
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Patent number: 10650312Abstract: Methods and systems for encoding digital information in nucleic acid (e.g., deoxyribonucleic acid) molecules without base-by-base synthesis, by encoding bit-value information in the presence or absence of unique nucleic acid sequences within a pool, comprising specifying each bit location in a bit-stream with a unique nucleic sequence and specifying the bit value at that location by the presence or absence of the corresponding unique nucleic acid sequence in the pool But, more generally, specifying unique bytes in a bytestream by unique subsets of nucleic acid sequences. Also disclosed are methods for generating unique nucleic acid sequences without base-by-base synthesis using combinatorial genomic strategies (e.g., assembly of multiple nucleic acid sequences or enzymatic-based editing of nucleic acid sequences).Type: GrantFiled: December 21, 2017Date of Patent: May 12, 2020Assignee: CATALOG TECHNOLOGIES, INC.Inventors: Nathaniel Roquet, Hyunjun Park, Swapnil P. Bhatia