Abstract: Systems and methods are provided to provide guidance to a user regarding management of a physiologic condition such as diabetes. The determination may be based upon a patient glucose concentration level. The glucose concentration level may be provided to a stored model to determine a state. The guidance may be determined based at least in part on the determined state.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, which inhibit the cellular entry of hepatitis B virus (HBV) and/or hepatitis D virus (HDV) or interfere with the function of the life cycle of HBV and/or HDV and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV and/or HDV infection. The invention also relates to methods of treating an HBV and/or HDV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof: which inhibit the cellular entry of hepatitis B virus (HBV) and/or hepatitis D virus (HDV) or interfere with the function of the life cycle of HBV and/or HDV and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV and/or HDV infection. The invention also relates to methods of treating an HBV and/or HDV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof: which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof: which inhibit the cellular entry of hepatitis B virus (HBV) and/or hepatitis D virus (HDV) or interfere with the function of the life cycle of HBV and/or HDV and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV and/or HDV infection. The invention also relates to methods of treating an HBV and/or HDV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: Devices used to deploy transvascular medical device systems and methods for using such devices are described in this document. For example, this document describes dilating introducer devices used for the percutaneous vascular deployment of catheter-based medical devices such as structural heart medical devices. Such dilating introducer devices can facilitate the percutaneous vascular deployment of catheter-based medical devices without an additional introducer sheath.

Abstract: Systems and methods for providing for visualization and analysis of geospatial data are described. An example method includes automatically generating a first map comprising a plurality of layers that each comprise part of the input data, providing a graphical user interface for receiving at least one selection from the user of one or more of the plurality of layers of the first map for display and an indication that the user has zoomed in on the first map to a first area featuring a symbol corresponding to an item of interest, and automatically generating, based on bounds of the dataset, a second map showing a second area of a bounding shape selected to fit the data related to the item of interest.

Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.

Abstract: An upper for an article of footwear and a method of manufacturing the upper for an article of footwear are disclosed. The upper incorporates a textile element with edges that are joined together to define at least a portion of a void for receiving a foot. The joined edges form a plurality of seams within the textile element, including a longitudinal seam extending on the lower region of the upper from a heel region to a forefoot region. Various warp knitting or weft knitting processes, including circular knitting, may be utilized to form the textile element.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof: which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: A method for operating a fuel cell system comprising a fuel cell assembly of a plurality of fuel cells configured to generate electrical power from a fuel flow and an oxidant flow to the plurality of fuel cells, the fuel cell assembly arranged in combination with a coolant storage module configured to supply the fuel cell assembly with a flow of coolant, the method performed when the temperature of the coolant in the coolant storage module is below a coolant temperature threshold and comprises; a first phase performed prior to activation of a coolant pump configured to deliver coolant from the coolant storage module to the fuel cell assembly and a second phase performed after activation of the coolant pump.

Abstract: The present invention discloses compounds of Formula (Ia), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (Ia) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (Ia) or a pharmaceutically acceptable salt thereof.

Abstract: Systems and methods for providing for visualization and analysis of geospatial data are described. An example method includes automatically generating a first map comprising a plurality of layers that each comprise part of the input data, providing a graphical user interface for receiving at least one selection from the user of one or more of the plurality of layers of the first map for display and an indication that the user has zoomed in on the first map to a first area featuring a symbol corresponding to an item of interest, and automatically generating, based on bounds of the dataset, a second map showing a second area of a bounding shape selected to fit the data related to the item of interest.

Abstract: Embodiments of the invention disclosed relate to systems and methods for facilitating the development of an athlete in a given sport. In one embodiment, a system can include one or more computing devices communicating via a computer network to receive input associated with Skill Scores and to compute and store an Athlete Development Rating (ADR) based at least on said input. In one embodiment, the ADR is based on a composite score of one or more Skills Scores and/or one or more Skill Group Scores. In certain embodiments, Skill Scores are associated with date data to provide a historical view of the athlete's development. In some embodiments, Skill Scores can be based on quantitative, objective assessments and/or qualitative, subjective expert assessments. Program modules can be configured to display historical ADR data, Skill Scores, and/or Skill Group Scores.

Abstract: Systems and methods for providing for visualization and analysis of geospatial data are described. An example method includes receiving input data comprising at least geospatial data; automatically generating a first map comprising a plurality of layers, each comprising part of the input data; providing a graphical user interface (GUI) for receiving selection(s) from a user of one or more layers of the first map for display; automatically generating a second map based on the selection(s); and causing display of the second map on a client device. Input data may originate from several data sources and include documents from a search and analytics engine. The map's visual properties are configurable based on user input via the GUI or a configuration. The example method combines server-side clustering and client-side symbolization to seamlessly create maps showing data of arbitrary size. The example method provides real-time full-text searching of map data of any size.

Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable slat thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: Disclosed is a cooling module for use in a fuel cell system, the module includes a tank configured to receive a coolant therein, a coolant, a pump in fluid communication with the coolant in the tank and the fuel cell system, the pump being configured to transport the coolant to the fuel cell system, a heating element within the coolant in the tank, the heating element configured to heat the coolant, and at least one sensor in signal communication with a controller and in fluid communication with the tank. The sensor is configured to detect a change corresponding to the presence or absence of sufficient liquid coolant to initiate said pump, and the controller processes sensor data and is configured to actuate the pump.

Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable slat thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable slat thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable slat thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.