Patents by Inventor Natividad Toledo Mesa

Natividad Toledo Mesa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7452904
    Abstract: Carbamate of general formula (I), wherein R1, R2, and R3 are H, OH, NO2, SH, CN, F, Cl, Br, I, COOH, CONH2, (C1-C4)-alkoxycarbonyl, (C1-C4)-alkylsulfanyl, (C1-C4)-alkylsulfinyl, (C1-C4)-alkylsulfonyl, (C1-C4)-alkoxyl optionally substituted with one or several F, and (C1-C4)-alkyl optionally substituted with one or several F or OH; R4 is cycloalkyl, phenyl, heteroaryl or a bicyclic ring system; R5 is cycloalkyl, (C5-C10)-alkyl, a substituted (C1-C10)-alkyl; and X? is a physiologically acceptable anion. Carbamate (I) is selective M3 receptor antagonists versus M2 receptor and may be used for the treatment of urinary incontinence (particularly, the one caused by overactive bladder), irritable bowel syndrome, and respiratory disorders (particularly, chronic obstructive pulmonary disease, chronic bronchitis, asthma, emphysema, and rhinitis), as well as in ophthalmic interventions.
    Type: Grant
    Filed: December 18, 2002
    Date of Patent: November 18, 2008
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Juan Lorenzo Catena Ruiz, Carles Farrerons Gallemi, Anna Fernandez Serrat, Ignacio José Miquel Bono, Dolors Balsa Lopez, Carmen Lagunas Arnal, Carolina Salcedo Roca, Natividad Toledo Mesa, Andrés Fernandez Garcia
  • Publication number: 20060160894
    Abstract: Compounds of general structure (I), wherein the central benzene ring may be substituted in the meta- or para-position; -A is an optionally substituted hydroxyl, alkoxyl, hydroxylamine, alkoxylamine or amine radical; -W is an N- and C-linked biradical selected from several possibilities; and -Z is a carbon radical selected from several possibilities. These compounds are PPAR? and PPAR?/PPAR? modulators and, therefore, are useful for the prophylactic and/or curative treatment of a condition or a disease mediated by these recetpcors.
    Type: Application
    Filed: June 11, 2004
    Publication date: July 20, 2006
    Applicant: LABORATORIOS S.A.L.V.A.T.,S.A.
    Inventors: Anna Fernandez Serrat, Carmen Serra Comas, Dolors Balsa Lopez, Amadeu Llebaria Soldevila, Carles Farrerons Gallemi, Ignacio Miquel Bono, Juan Catena, Carmen Lagunas Arnal, Arnau Cordomi Montoya, Carolina Salcedo Roca, Natividad Toledo Mesa, Pedro Marrero Gonzalez, Diego Haro Bautista, Andres Fernandez Garcia
  • Publication number: 20050043349
    Abstract: Carbamate of general formula (I), wherein R1, R2, and R3 are H, OH, NO2, SH, CN, F, Cl, Br, I, COOH, CONH2, (C1-C4)-alkoxycarbonyl, (C1-C4)-alkylsulfanyl, (C1-C4)-alkylsulfinyl, (C1-C4)-alkylsulfonyl, (C1-C4)-alkoxyl optionally substituted with one or several F, and (C1-C4)-alkyl optionally substituted with one or several F or OH; R4 is cycloalkyl, phenyl, heteroaryl or a bicyclic ring system; R5 is cycloalkyl, (C5-C10)-alkyl, a substituted (C1-C10)-alkyl; and X? is a physiologically acceptable anion. Carbamate (I) is selective M3 receptor antagonists versus M2 receptor and may be used for the treatment of urinary incontinence (particularly, the one caused by overactive bladder), irritable bowel syndrome, and respiratory disorders (particularly, chronic obstructive pulmonary disease, chronic bronchitis, asthma, emphysema, and rhinitis), as well as in ophthalmic interventions.
    Type: Application
    Filed: December 18, 2002
    Publication date: February 24, 2005
    Applicant: Laboratorios S.A.L.V.A.T.
    Inventors: Juan Catena Ruiz, Carles Farrerons Gallemi, Anna Fernandez Serrat, Ignacio Miquel Bono, Dolors Balsa Lopez, Carmen Lagunas Arnal, Carolina Salcedo Roca, Natividad Toledo Mesa, Andres Fernandez Garcia
  • Publication number: 20050014806
    Abstract: Compounds of formula (I), wherein X is O, S, NH, OCO, NH—CO, NH—COO, NH—CO—NH, NH—CS or NH—CS—NH; R4 is H, (C1-C3)-alkyl optionally substituted by halogen, or a C-linked heterocyclic radical selected from several possibilities; R1 and R3 are H or F; and R2 is an N-linked or C-linked heterocyclic radical, are useful in the treatment of microbial infections in human or animal body.
    Type: Application
    Filed: July 17, 2002
    Publication date: January 20, 2005
    Inventors: Carles Farrerons Gallemi, Carmen Lagunas Arnal, Anna Fernandez Serrat, Juan Catena Ruiz, Ignacio Miquel Bono, Dolors Balsa Lopez, Carolina Salcedo Roca, Natividad Toledo Mesa, Andres Fernandez Garcia