Patents by Inventor Natsuki Mori
Natsuki Mori has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20080255371Abstract: The present invention provides a method to improve the optical purity of 1-benzyl-3-aminopyrrolidine having a low optical purity using an inexpensive agent via a simple procedure. The present invention provides a method for improving the optical purity of 1-benzyl-3-aminopyrrolidine including the steps of converting 1-benzyl-3-aminopyrrolidine into an equimolar salt with an optically inactive acid, and recovering the salt as crystals. The present invention also provides a salt of 1-benzyl-3-aminopyrrolidine that is used in the method.Type: ApplicationFiled: August 3, 2007Publication date: October 16, 2008Applicant: Kaneka CorporationInventors: Fumihiko Kano, Natsuki Mori
-
Patent number: 7268236Abstract: The present invention provides a method to improve the optical purity of 1-benzyl-3-aminopyrrolidine having a low optical purity using an inexpensive agent via a simple procedure. The present invention provides a method for improving the optical purity of 1-benzyl-3-aminopyrrolidine including the steps of converting 1-benzyl-3-aminopyrrolidine into an equimolar salt with an optically inactive acid, and recovering the salt as crystals. The present invention also provides a salt of 1-benzyl-3-aminopyrrolidine that is used in the method.Type: GrantFiled: March 28, 2003Date of Patent: September 11, 2007Assignee: Kaneka CorporationInventors: Fumihiko Kano, Natsuki Mori
-
Patent number: 6992205Abstract: Sulfonic acid ester derivatives represented by the general formula (4) or (5) are produced by reacting an amino alcohol derivative represented by the general formula (1) or (2) with an organic sulfonyl halide represented by the general formula (3), in a mixed solvent composed of an aprotic organic solvent and water in the presence of a non-water-prohibiting inorganic base. This procedure can be carried out in a simple, easy, safe and economical manner while reducing the load on the environment. Wherein n represents an integer of 0 to 5, A represents a phenyl group, which may be substituted, R represents a methanesulfonyl, ethanesulfonyl, p-toluenesulfonyl or p-nitrobenzenesulfonyl group and X represents a chloride, bromine or iodine atom.Type: GrantFiled: May 16, 2003Date of Patent: January 31, 2006Assignee: Kaneka CorporationInventors: Fumihiko Kano, Shigeki Kunihiro, Noritaka Yoshida, Natsuki Mori
-
Patent number: 6864372Abstract: Sulfonic acid ester derivatives represented by the general formula (4) or (5) are produced by reacting an amino alcohol derivative represented by the general formula (1) or (2) with an organic sulfonyl halide represented by the general formula (3), in a mixed solvent composed of an aprotic organic solvent and water in the presence of a non-water-prohibiting inorganic base. This procedure can be carried out in a simple, easy, safe and economical manner while reducing the load on the environment. Wherein n represents an integer of 0 to 5, A represents a phenyl group, which may be substituted, R represents a methanesulfonyl, ethanesulfonyl, p-toluenesulfonyl or p-nitrobenzenesulfonyl group and X represents a chloride, bromine or iodine atom.Type: GrantFiled: May 16, 2003Date of Patent: March 8, 2005Assignee: Kaneka CorporationInventors: Fumihiko Kano, Shigeki Kunihiro, Noritaka Yoshida, Natsuki Mori
-
Publication number: 20040249169Abstract: The present invention provides a method to improve the optical purity of 1-benzyl-3-aminopyrrolidine having a low optical purity using an inexpensive agent via a simple procedure. The present invention provides a method for improving the optical purity of 1-benzyl-3-aminopyrrolidine including the steps of converting 1-benzyl-3-aminopyrrolidine into an equimolar salt with an optically inactive acid, and recovering the salt as crystals. The present invention also provides a salt of 1-benzyl-3-aminopyrrolidine that is used in the method.Type: ApplicationFiled: March 22, 2004Publication date: December 9, 2004Inventors: Fumihiko Kano, Natsuki Mori
-
Patent number: 6794519Abstract: Sulfonic acid ester derivatives represented by the general formula (4) or (5) are produced by reacting an amino alcohol derivative represented by the general formula (1) or (2) with an organic sulfonyl halide represented by the general formula (3), in a mixed solvent composed of an aprotic organic solvent and water in the presence of a non-water-prohibiting inorganic base. This procedure can be carried out in a simple, easy, safe and economical manner while reducing the load on the environment. Wherein n represents an integer of 0 to 5, A represents a phenyl group, which may be substituted, R represents a methanesulfonyl, ethanesulfonyl, p-toluenesulfonyl or p-nitrobenzenesulfonyl group and X represents a chloride, bromine or iodine atom.Type: GrantFiled: February 8, 2002Date of Patent: September 21, 2004Assignee: Kaneka CorporationInventors: Fumihiko Kano, Shigeki Kunihiro, Noritaka Yoshida, Natsuki Mori
-
Publication number: 20030176713Abstract: Sulfonic acid ester derivatives represented by the general formula (4) or (5) are produced by reacting an amino alcohol derivative represented by the general formula (1) or (2) with an organic sulfonyl halide represented by the general formula (3), in a mixed solvent composed of an aprotic organic solvent and water in the presence of a non-water-prohibiting inorganic base. This procedure can be carried out in a simple, easy, safe and economical manner while reducing the load on the environment.Type: ApplicationFiled: May 16, 2003Publication date: September 18, 2003Inventors: Fumihiko Kano, Shigeki Kunihiro, Noritaka Yoshida, Natsuki Mori
-
Publication number: 20030176711Abstract: Sulfonic acid ester derivatives represented by the general formula (4) or (5) are produced by reacting an amino alcohol derivative represented by the general formula (1) or (2) with an organic sulfonyl halide represented by the general formula (3), in a mixed solvent composed of an aprotic organic solvent and water in the presence of a non-water-prohibiting inorganic base. This procedure can be carried out in a simple, easy, safe and economical manner while reducing the load on the environment.Type: ApplicationFiled: May 16, 2003Publication date: September 18, 2003Inventors: Fumihiko Kano, Shigeki Kunihiro, Noritaka Yoshida, Natsuki Mori
-
Publication number: 20030162966Abstract: Sulfonic acid ester derivatives represented by the general formula (4) or (5) are produced by reacting an amino alcohol derivative represented by the general formula (1) or (2) with an organic sulfonyl halide represented by the general formula (3), in a mixed solvent composed of an aprotic organic solvent and water in the presence of a non-water-prohibiting inorganic base. This procedure can be carried out in a simple, easy, safe and economical manner while reducing the load on the environment.Type: ApplicationFiled: February 8, 2002Publication date: August 28, 2003Inventors: Fumihiko Kano, Shigeki Kunihiro, Noritaka Yoshida, Natsuki Mori
-
Patent number: 6140527Abstract: This invention has its objects to provide a process for producing a butyric acid ester derivative of the above general formula (2) which is capable of removing various impurity byproducts whose formation cannot be avoided by the prior art technology, particularly the compound of the above general formula (1), with good efficiency.This invention is related to a process for producing a butyric acid ester derivative of the general formula (2) which comprises treating a mixture containing a compound of the following general formula (1) with an addition reagent capable of adding itself to said ethylenic bond to thereby convert said compound of the general formula (1) to an addition product which can be easily separated from said butyric acid ester derivative of the general formula (2) and a process for producing a butyric acid ester derivative of the general formula (2) which comprises reacting a compound of the general formula (3) with a salt of prussic acid by a flow method.HOCH.sub.2 --CH.dbd.Type: GrantFiled: September 7, 1999Date of Patent: October 31, 2000Assignee: Kaneka CorporationInventors: Shigeki Kunihiro, Fumihiko Kano, Natsuki Mori
-
Patent number: 6005119Abstract: It is an object of the present invention to provide a process for producing an pyrrolidine derivative of general formula (2) or a salt thereof in a simple and economical manner and with good productivity and high yields.The present invention consists in a process for producing a pyrrolidine derivative of the general formula (2) or a salt thereof which comprises subjecting a compound of the general formula (1) to hydrogenolysis using a metal catalyst in the presence of at least one protic acid selected from the group consisting of hydrochloric acid, sulfuric acid, phosphoric acid, p-toluenesulfonic acid, methanesulfonic acid, acetic acid, n-butyric acid, trifluoroacetic acid and oxalic acid. ##STR1## R represents a 1-cyano-1,1-diphenylmethyl, 1-carbamoyl-1,1-diphenylmethyl, n-butyryloxy, methanesulfonyloxy or p-toluenesulfonyloxy group.Type: GrantFiled: April 5, 1999Date of Patent: December 21, 1999Assignee: Kaneka CorporationInventors: Natsuki Mori, Noritaka Yoshida, Takeshi Furuta, Kazunori Kan
-
Patent number: 5756768Abstract: There is described a process for preparing 3-(2-thienylthio)butyric acid by converting a compound having the formula (III): ##STR1## wherein R is a straight chain or branched C.sub.1 to C.sub.4 alkyl group, whereby the production of 3-(3-thienylthio)butyric acid as a by-product which is the position isomer can be controlled to at most 0.1 mol %. 3-(2-Thienylthio)butyric acid is a useful compound as an intermediate for a medicinal compound.Type: GrantFiled: August 22, 1996Date of Patent: May 26, 1998Assignee: Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Fumihiko Kanou, Toshihiro Takeda, Natsuki Mori, Kazunori Kan
-
Patent number: 5723628Abstract: There is described a process for preparing 3-(2-thienylthio)butyric acid by converting a compound having the formula (III): ##STR1## wherein R is a straight chain or branched C.sub.1 to C.sub.4 alkyl group, whereby the production of 3-(3-thienylthio)butyric acid as a by-product which is the position isomer can be controlled to at most 0.1 mol %. 3-(2-Thienylthio)butyric acid is a useful compound as an intermediate for a medicinal compound.Type: GrantFiled: August 22, 1996Date of Patent: March 3, 1998Assignee: Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Fumihiko Kanou, Toshihiro Takeda, Natsuki Mori, Kazunori Kan
-
Patent number: 5187094Abstract: A method for the preparation of optically active 3-hydroxypyrrolidine derivatives is disclosed, which comprises the steps of: hydrolyzing a mixture of (R)- and (S)-N-benzyl-3-acyloxypyrrolidine by the use of microorganisms or enzymes with stereospecific esterase activity; and separating optically active N-benzyl-3-hydroxypyrrolidine and optically active N-benzyl-3-acyloxypyrrolidine from the hydrolysate obtained in the foregoing step.Type: GrantFiled: September 24, 1991Date of Patent: February 16, 1993Assignee: Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Ikuo Sawa, Natsuki Mori, Shunichi Maemoto, Hidetoshi Kutsuki, Junzo Hasegawa
-
Patent number: 4857468Abstract: A process for preparing optically active 2-halo-1-phenyl ethanol having the general formula [I*]: ##STR1## wherein X is a halogen atom, by asymmetrically reducing 2-halo-acetophenone having the general formula [II]: ##STR2## wherein X is as above, to give optically active 2-halo-1-phenyl ethanol, (R)-form or (S)-form, employing the microorganism. ##STR3## According to the present invention, optically active 2-halo-1-phenyl ethanol can be prepared with a good optical purity and yield in a simple process.Type: GrantFiled: April 10, 1986Date of Patent: August 15, 1989Assignee: Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Hidetoshi Kutsuki, Ikuo Sawa, Natsuki Mori, Junzo Hasegawa, Kiyoshi Watanabe