Patents by Inventor Natsuko KIZU

Natsuko KIZU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stable Fc binding protein, method for producing said protein, and antibody adsorbent in which said protein is used
    Patent number: 11427828
    Abstract: The present invention addresses the problem of providing FcRn having improved stability with respect to heat and acids, a method for producing said FcRn, an antibody adsorbent in which said FcRn is used, and an antibody isolation method in which said adsorbent is used. The above problem is solved by substituting an amino acid residue at a specific position in an extracellular region of a human FcRn ? chain and/or a ?2 microglobulin region of a human FcRn ? chain by another specific amino acid.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: August 30, 2022
    Assignee: TOSOH CORPORATION
    Inventors: Yosuke Terao, Naoki Yamanaka, Natsuko Kizu, Satoshi Endo, Seigo Oe
  • Fc-binding protein, method for producing said protein, antibody adsorbent using said protein, and method for separating antibody using said adsorbent
    Patent number: 10815289
    Abstract: Provided are: an Fc-binding protein having improved stability, particularly to heat and acid; a method for producing the protein; an antibody adsorbent using the protein; and a method for separating the antibodies using the adsorbent. Specifically provided are: an Fc-binding protein having improved stability to heat and acid, achieved by substituting an amino-acid residue in a specific position in the extracellular region of human FcyRIIIa with another specific amino acid; a method for producing the protein; an antibody adsorbent using the protein; and a method for separating the antibodies using the adsorbent.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: October 27, 2020
    Assignee: TOSOH CORPORATION
    Inventors: Yoshiharu Asaoka, Toru Tanaka, Yosuke Terao, Naoki Yamanaka, Natsuko Kizu, Masaru Aoki, Teruhiko Ide
  • STABLE FC BINDING PROTEIN, METHOD FOR PRODUCING SAID PROTEIN, AND ANTIBODY ADSORBENT IN WHICH SAID PROTEIN IS USED
    Publication number: 20200283779
    Abstract: The present invention addresses the problem of providing FcRn having improved stability with respect to heat and acids, a method for producing said FcRn, an antibody adsorbent in which said FcRn is used, and an antibody isolation method in which said adsorbent is used. The above problem is solved by substituting an amino acid residue at a specific position in an extracellular region of a human FcRn ? chain and/or a ?2 microglobulin region of a human FcRn ? chain by another specific amino acid.
    Type: Application
    Filed: April 13, 2018
    Publication date: September 10, 2020
    Applicant: TOSOH CORPORATION
    Inventors: Yosuke TERAO, Naoki YAMANAKA, Natsuko KIZU, Satoshi ENDO, Seigo OE
  • IMPROVED FC-BINDING PROTEIN, METHOD FOR PRODUCING SAID PROTEIN, ANTIBODY ADSORBENT USING SAID PROTEIN, AND METHOD FOR SEPARATING ANTIBODY USING SAID ADSORBENT
    Publication number: 20190211077
    Abstract: Provided are: an Fc-binding protein having improved stability, particularly to heat and acid; a method for producing the protein; an antibody adsorbent using the protein; and a method for separating the antibodies using the adsorbent. Specifically provided are: an Fc-binding protein having improved stability to heat and acid, achieved by substituting an amino-acid residue in a specific position in the extracellular region of human FcyRIIIa with another specific amino acid; a method for producing the protein; an antibody adsorbent using the protein; and a method for separating the antibodies using the adsorbent.
    Type: Application
    Filed: June 24, 2015
    Publication date: July 11, 2019
    Applicant: TOSOH CORPORATION
    Inventors: Yoshiharu ASAOKA, Toru TANAKA, Yosuke TERAO, Naoki YAMANAKA, Natsuko KIZU, Masaru AOKI, Teruhiko IDE
  • IMPROVED FC-BINDING PROTEIN, METHOD FOR PRODUCING SAID PROTEIN, ANTIBODY ADSORBENT USING SAID PROTEIN, AND METHOD FOR SEPARATING ANTIBODY USING SAID ADSORBENT
    Publication number: 20170218044
    Abstract: Provided are: an Fc-binding protein having improved stability, particularly to heat and acid; a method for producing the protein; an antibody adsorbent using the protein; and a method for separating the antibodies using the adsorbent. Specifically provided are: an Fc-binding protein having improved stability to heat and acid, achieved by substituting an amino-acid residue in a specific position in the extracellular region of human FcyRIIIa with another specific amino acid; a method for producing the protein; an antibody adsorbent using the protein; and a method for separating the antibodies using the adsorbent.
    Type: Application
    Filed: June 24, 2015
    Publication date: August 3, 2017
    Applicant: TOSOH CORPORATION
    Inventors: Yoshiharu ASAOKA, Toru TANAKA, Yosuke TERAO, Naoki YAMANAKA, Natsuko KIZU, Masaru AOKI, Teruhiko IDE