Abstract: The present invention is directed to a composition comprising phytoene, phytofluene, and zeta carotene, and methods of using the same, such as for improving skin barrier functionality.

Abstract: A compound, composition, and method for the protection of skin from the harmful effects of radiation, and particularly the harmful effects of high energy visible (HEV) radiation, are disclosed. The compound is a melanin derivative that can be formulated into compositions containing the melanin derivative and a suitable carrier. The composition is topically applied to the skin to reduce the risk of photoaging and improve skin repair due to damage from radiation.

Abstract: A compound, composition, and method for the protection of skin from the harmful effects of radiation, and particularly the harmful effects of high energy visible (HEV) radiation, are disclosed. The compound is a melanin derivative that can be formulated into compositions containing the melanin derivative and a suitable carrier. The composition is topically applied to the skin to reduce the risk of photoaging and improve skin repair due to damage from radiation.

Abstract: A compound, composition, and method for the protection of skin from the harmful effects of radiation, and particularly the harmful effects of high energy visible (HEV) radiation, are disclosed. The compound is a melanin derivative that can be formulated into compositions containing the melanin derivative and a suitable carrier. The composition is topically applied to the skin to reduce the risk of photoaging and improve skin repair due to damage from radiation.

Abstract: Provided are topical pharmaceutical compositions including fatty acid bile acid conjugates (FABACs) as an active ingredient. Further provided are methods of using pharmaceutical compositions comprising FABACs for treating skin conditions associated with altered sebum levels, including but not limited to, acne.

Abstract: Provided are topical compositions including fatty acid bile acid conjugates (FABACs). Further provided are methods of using the disclosed compositions for preventing, attenuating or treating skin aging and symptoms related thereto.

Abstract: A compound, composition, and method for the protection of skin from the harmful effects of radiation, and particularly the harmful effects of high energy visible (HEV) radiation, are disclosed. The compound is a melanin derivative that can be formulated into compositions containing the melanin derivative and a suitable carrier. The composition is topically applied to the skin to reduce the risk of photoaging and improve skin repair due to damage from radiation.

Abstract: An improved cosmetic and dermatological composition and a method for treating hyperpigmented skin is disclosed. The composition demonstrates an enhanced ability to lighten mammalian skin color, and is nontoxic and nonirritating. The composition comprises a hydroxycinnamic acid or a methoxycinnamic acid dissolved in a compound having one or more hydroxy groups, like a monoC1-4alkyl ether of an ethylene glycol or a monoC1-4alkyl ether of a propylene glycol oligomer, and/or a silicone fluid.

Abstract: A delivery system for topically applied compounds is disclosed. The delivery system contains a fatty acid, a phospholipid, and an oil, and is activated by the addition of water. The delivery system is admixed with a topically applied compound and water to provide a composition suitable for application to the skin or hair. The relative amounts of delivery system ingredients provide round, flexible vesicles that allow penetration of the topically applied compound to the epidermis and dermis, vesicles having a partially ruptured membrane for a controlled delivery of the topically applied drug to the epidermis and dermis, completely ruptured vesicles in the form of lamellar sheets that allow the topically applied compound to be retained in the stratum corneum, and mixtures thereof.

Abstract: Ceramide NS and butylene glycol can form a topical composition in which the ceramide NS is lamellar. The topical compositions can be used in a formulation such as a lotion, gel, or cream and can be used to treat an aging-related skin condition, dry skin, skin irritation, skin wrinkles, or other conditions in which the skin barrier is compromised, damaged, or disordered. These compositions can manufactured by dispersing ceramide NS in butylene glycol while heating and stirring.

Abstract: An improved cosmetic and dermatological composition and a method for treating hyperpigmented skin is disclosed. The composition demonstrates an enhanced ability to lighten mammalian skin color, and is nontoxic and nonirritating. The composition comprises a hydroxycinnamic acid or a methoxycinnamic acid dissolved in a compound having one or more hydroxy groups, like a PEG-4 through PEG-20, a monoC1-4alkyl ether of an ethylene glycol, or a monoC1-4alkyl ether of a propylene glycol oligomer, and/or a silicone fluid.