Abstract: The invention provides methods and compositions for local administration of therapeutic agents to the rectum or colon, such as by enema. The methods and compositions are useful for treatment of inflammatory bowel disease, including Crohn's disease and ulcerative colitis.

Abstract: The invention provides methods and compositions for local administration of therapeutic agents to the rectum or colon, such as by enema. The methods and compositions are useful for treatment of inflammatory bowel disease, including Crohn's disease and ulcerative colitis.

Abstract: A method of delivering nicotine to treat dyskinesia, such as Levodopa induced dyskinesia (LID), includes delivering a first dose of nicotine to a patient using a transdermal delivery device and delivering a second dose of nicotine to the patient using the transdermal delivery device. The first and second doses are timed such that a refractory period between peak plasma levels of nicotine in the patient prevents desensitization of nicotinic acetylcholine receptors while reducing symptoms of LID.

Abstract: A method for operating a first near field communication, NFC, device, wherein the NFC device comprises an NFC interface and a memory, the method comprising: i) receiving a request for a service from a second NFC device at the NFC interface, ii) allocating a first information from a first memory unit of the memory that is configured to take part in providing the service, iii) allocating a second information from a second memory unit that is not configured to take part in providing the service, and transferring the second information from the second memory unit to the first memory unit, hereby iv) transferring at least a part of the first information and/or at least a part of the second information virtually beyond the first memory unit, v) combining the first information and the second information into a message, and vi) providing the message to the second NFC device as a response to the request.

Abstract: A method for operating a first near field communication, NFC, device, wherein the NFC device comprises an NFC interface and a memory, the method comprising: i) receiving a request for a service from a second NFC device at the NFC interface, ii) allocating a first information from a first memory unit of the memory that is configured to take part in providing the service, iii) allocating a second information from a second memory unit that is not configured to take part in providing the service, and transferring the second information from the second memory unit to the first memory unit, hereby iv) transferring at least a part of the first information and/or at least a part of the second information virtually beyond the first memory unit, v) combining the first information and the second information into a message, and vi) providing the message to the second NFC device as a response to the request.

Abstract: Systems and methods are provided herein for transdermal delivery of an opioid. The opioids can be delivered in a decreasing dose (dose-tapering) manner to minimize withdrawal symptoms and abuse. The systems are also designed to limit a person besides the patient from receiving the drug with the transdermal delivery device. The systems can also include abuse-deterrence features that limit the ability of a patient or unauthorized user from tampering with the device to receive the active ingredient. Novel transdermal drug delivery formulations are also provided that include an opioid agonist or partial agonist and opioid antagonist which prevent the abuse of formulation.