Patents by Inventor Naveen K. Mehta

Naveen K. Mehta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230040528
    Abstract: In some aspects, the disclosure provides compositions and methods for detecting and monitoring the activity of proteases in vivo using affinity assays. The disclosure relates, in part, to the discovery that biomarker nanoparticles targeted to the lymph nodes of a subject are useful for the diagnosis and monitoring of certain medical conditions (e.g., metastatic cancer, infection with certain pathogenic agents).
    Type: Application
    Filed: August 2, 2022
    Publication date: February 9, 2023
    Applicant: Massachusetts Institute of Technology
    Inventors: Sangeeta N. Bhatia, Darrell J. Irvine, Karl Dane Wittrup, Andrew David Warren, Jaideep S. Dudani, Naveen K. Mehta
  • Patent number: 11448643
    Abstract: In some aspects, the disclosure provides compositions and methods for detecting and monitoring the activity of pro teases in vivo using affinity assays. The disclosure relates, in part, to the discovery that biomarker nanoparticles targeted to the lymph nodes of a subject are useful for the diagnosis and monitoring of certain medical conditions (e.g., metastatic cancer, infection with certain pathogenic agents).
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: September 20, 2022
    Assignee: Massachusetts Institute of Technology
    Inventors: Sangeeta N. Bhatia, Darrell J. Irvine, Karl Dane Wittrup, Andrew David Warren, Jaideep S. Dudani, Naveen K. Mehta
  • Publication number: 20190128873
    Abstract: In some aspects, the disclosure provides compositions and methods for detecting and monitoring the activity of pro teases in vivo using affinity assays. The disclosure relates, in part, to the discovery that biomarker nanoparticles targeted to the lymph nodes of a subject are useful for the diagnosis and monitoring of certain medical conditions (e.g., metastatic cancer, infection with certain pathogenic agents).
    Type: Application
    Filed: April 7, 2017
    Publication date: May 2, 2019
    Applicant: Massachusetts Institute of Technology
    Inventors: Sangeeta N. Bhatia, Darrell J. Irvine, Karl Dane Wittrup, Andrew David Warren, Jaideep S. Dudani, Naveen K. Mehta
  • Publication number: 20170252417
    Abstract: Protein antigens are provided. The protein antigens typically include a peptide antigen conjugated or fused to a chaperone protein to form a “chaperone-antigen” that increases lymph node uptake; improves an immune response; or a combination thereof relative to the peptide antigen alone. The immune response can be, for example, increased antigen-specific proliferation, enhanced cytokine production, stimulation of differentiation and/or effector functions, promotion of survival, rescue from exhaustion and/or anergy of T cells, or a combination thereof. Chaperon-antigens can also be used to induce tolerance and increase immune suppressive responses. In the most preferred embodiments, the peptide antigen is fused to the chaperone protein to form a fusion protein. The “chaperone-antigen” can be combined with an adjuvant to form a vaccine and administered to a subject to modulate an immune response to the antigen.
    Type: Application
    Filed: March 7, 2017
    Publication date: September 7, 2017
    Inventors: Darrell Irvine, Karl Dane Wittrup, Naveen K. Mehta, Kavya Rakhra, Eric Franklin Zhu