Abstract: The disclosed technology is generally directed to virtual machines. In one example of the technology, a network change from a first virtual network to a second virtual network is reconfigured for a first virtual machine that is executing on a first virtual machine host. The reconfiguring includes the following. In the first virtual machine host, a mapping change from the first virtual network to the second virtual network is configured by reprogramming drivers in the first virtual machine host for route mapping for the second virtual network. A Dynamic Host Configuration Protocol (DHCP) retrigger is caused without rebooting the first virtual machine. A configuration file is provided to the first virtual machine. The configuration file includes user-specific networking settings. The first virtual machine is reconfigured in accordance with the user-specific networking settings.

Abstract: Apparatus and methods for deploying a web application including a plurality of binary objects. The methods may include isolating from the plurality of class files a class file in which a run-time behavior occurs. The methods may include updating the class file to produce a modified class file that does not have the behavior. The methods may include testing performance of the modified class file. The methods may include storing the class file in a dynamic configuration database. The methods may include recognizing the modified class file as being modified. The methods may include, using a cron job processor, reading the metadata. The methods may include compiling the modified class file into binary code. The methods may include executing the binary code instead of a different binary code that corresponds to the class file in which the run-time behavior occurs.

Abstract: The invention provides a novel method for the chemical synthesis of 2?,3?-cyclic phosphate and phosphorothioate of mono and terminated oligonucleotides synthesis. The invention also provides a novel method of for the chemical synthesis of 2?,3?- and 3?,5?-cyclic phosphate and phosphorothioate mononucleotide nucleotides. The process is based on quick and efficient cyclization of phosphoramidate moiety and neighboring hydroxyl group. The present invention is directed towards the synthesis of high purity DNA and RNAs, specifically to introduce cyclic phosphate at 3?-end of oligonucleotides. Such DNA and RNA's have extensive application in therapeutics, diagnostics, drug design, and selective inhibition of an RNA sequence within cellular environment, in pre-tRNA cleavage and in ribozyme ligation. The 2?,3?-cyclic phosphate nucleosides are involved in a vast number of applications in molecular biology in general and mammalian cells in particular.

Abstract: The invention provides a novel method of 2?,3?-cyclic phosphate and phosphorothioate of mono and oligonucleotide synthesis. The invention also provides a novel method of the synthesis of 3?,5?-cyclic phosphate and phosphorothioate mononucleotide. The invention also envisions providing kits comprising at least one composition disclosed in the present invention.