Abstract: The present invention provides a syringe for filtering a liquid comprising: a housing with a plunger slidable therein; an inlet for taking in liquid from a liquid source into the housing; an outlet for expelling liquid from the inside of the housing; a filter; and a rotatable valve member being rotatable between a first position and a second position; wherein rotation of the valve member to the first position permits liquid that is drawn through the inlet into the housing by pulling the plunger to bypass the filter, and rotation of the valve member to the second position forces liquid that is expelled from the inside of the housing by pushing the plunger to pass through the filter and out of the outlet.

Abstract: Embodiments of the present invention relate to a filtration device and method for filtering liquids. In conventional devices, a liquid is placed in a vial, and a plunger, having a filter membrane located at one end, is depressed into the vial, causing the liquid to pass through the filter membrane into the interior of the plunger, where it is stored until required for further processing. However, such plungers are typically made of a plastics material. It is undesirable to store the filtered liquid in contact with plastics for extended periods of time, as contaminants may leach from the plastics material into the sample. In embodiments of the present invention, a filtrate receptacle made from a different material to the plunger, such as a glass material, is located in the interior of the plunger and the filtered liquid collected in the filtrate receptacle after passing through the filter membrane.

Abstract: The present invention provides a syringe for filtering a liquid comprising: a housing with a plunger slidable therein; an inlet for taking in liquid from a liquid source into the housing; an outlet for expelling liquid from the inside of the housing; a filter; and a rotatable valve member being rotatable between a first position and a second position; wherein rotation of the valve member to the first position permits liquid that is drawn through the inlet into the housing by pulling the plunger to bypass the filter, and rotation of the valve member to the second position forces liquid that is expelled from the inside of the housing by pushing the plunger to pass through the filter and out of the outlet.

Abstract: The disclosure relates to an in-hand operable compressor 200 for compressing syringeless filter devices 100. The compressor 200 includes a base 220 having a receiving well 222 adapted to receive a bottom portion of the uncompressed device 100, and a discrete top 210 having a receiving recess (212 FIG. 4) adapted to receive a top portion of the uncompressed device 100, said base and top being brought together in use by hand compression to cause compression of the device 100 located in the well and recess of the compressor. Surface formations 250 and 252 (FIG. 2) are complementary and inhibit misalignment of said well and recess during the in-hand compression.

Abstract: Embodiments of the present invention relate to a filtration device and method for filtering liquids. In conventional devices, a liquid is placed in a vial, and a plunger, having a filter membrane located at one end, is depressed into the vial, causing the liquid to pass through the filter membrane into the interior of the plunger, where it is stored until required for further processing. However, such plungers are typically made of a plastics material. It is undesirable to store the filtered liquid in contact with plastics for extended periods of time, as contaminants may leach from the plastics material into the sample. In embodiments of the present invention, a filtrate receptacle made from a different material to the plunger, such as a glass material, is located in the interior of the plunger and the filtered liquid collected in the filtrate receptacle after passing through the filter membrane.

Abstract: A solution for treating a nucleic acid duplex having a pH of from 3 to 11, comprising a soluble protein or mixture of proteins; and 0.1 mM to 10 mM divalent cations; wherein the nature and concentration of the protein or mixture of proteins is selected so that the solution is capable of inhibiting heat denaturation of a nucleic acid product.