Patents by Inventor Navneeth Thirumalai

Navneeth Thirumalai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR SHP1 MEDIATED NEUROPROTECTION
    Publication number: 20070065885
    Abstract: The effect of EPO on the phosphorylation of the EPO receptor, the activation of the MAP Kinase pathway, and the expression of SHP-1 were analyzed. EPO was observed to cause a decrease in the expression of its negative regulator SHP-1. The decrease observed at both the mRNA and protein level was dose dependent and persisted as long as 24 hr following EPO treatment. EPO can down regulate the expression of its own negative regulator as a means for increased potency in neurons. Assays were generated to identify compounds that are useful in regulating SHP1 activity in neural cells.
    Type: Application
    Filed: September 8, 2006
    Publication date: March 22, 2007
    Inventors: Michael Renzi, Navneeth Thirumalai, Linda Jolliffe, Francis Farrell
  • METHODS FOR SHP1 MEDIATED NEUROPROTECTION
    Publication number: 20070009967
    Abstract: The effect of EPO on the phosphorylation of the EPO receptor, the activation of the MAP Kinase pathway, and the expression of SHP-1 were analyzed. EPO was observed to cause a decrease in the expression of its negative regulator SHP-1. The decrease observed at both the mRNA and protein level was dose dependent and persisted as long as 24 hr following EPO treatment. EPO can down regulate the expression of its own negative regulator as a means for increased potency in neurons. Assays were generated to identify compounds that are useful in regulating SHP1 activity in neural cells.
    Type: Application
    Filed: September 8, 2006
    Publication date: January 11, 2007
    Inventors: Michael RENZI, Navneeth Thirumalai, Linda Jolliffe, Francis Farrell
  • Methods for SHP1 mediated neuroprotection
    Patent number: 7129267
    Abstract: The effect of EPO on the phosphorylation of the EPO receptor, the activation of the MAP Kinase pathway, and the expression of SHP-1 were analyzed. EPO was observed to cause a decrease in the expression of its negative regulator SHP-1. The decrease observed at both the mRNA and protein level was dose dependent and persisted as long as 24 hr following EPO treatment. EPO can down regulate the expression of its own negative regulator as a means for increased potency in neurons. Assays were generated to identify compounds that are useful in regulating SHP1 activity in neural cells.
    Type: Grant
    Filed: March 11, 2003
    Date of Patent: October 31, 2006
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Michael Renzi, Navneeth Thirumalai, Linda Jolliffe, Francis X. Farrell
  • Use of erythropoietin in stroke recovery
    Publication number: 20040209812
    Abstract: The present invention demonstrates EPO's efficacy in promoting patient recovery following an ischemic event. The invention demonstrates that a longer window of opportunity exists for the initial uses of EPO in treating ischemic stroke than had been previously been understood.
    Type: Application
    Filed: March 26, 2004
    Publication date: October 21, 2004
    Inventors: Michael J. Renzi, Michael Gold, Kenneth James Rhodes, Navneeth Thirumalai, Francis Farrell, Linda Jolliffe
  • Methods for SHP1 mediated neuroprotection
    Publication number: 20030232749
    Abstract: The effect of EPO on the phosphorylation of the EPO receptor, the activation of the MAP Kinase pathway, and the expression of SHP-1 were analyzed. EPO was observed to cause a decrease in the expression of its negative regulator SHP-1. The decrease observed at both the mRNA and protein level was dose dependent and persisted as long as 24 hr following EPO treatment. EPO can down regulate the expression of its own negative regulator as a means for increased potency in neurons. Assays were generated to identify compounds that are useful in regulating SHP1 activity in neural cells.
    Type: Application
    Filed: March 11, 2003
    Publication date: December 18, 2003
    Inventors: Michael Renzi, Navneeth Thirumalai, Linda Jolliffe, Francis X. Farrell