Patents by Inventor Nazer Khalaf

Nazer Khalaf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Reduced viscosity protein pharmaceutical formulations
    Patent number: 11459401
    Abstract: Described herein are therapeutic protein formulations comprising N-methyl pyrrolidone (NMP), methods related to reducing viscosity of pharmaceutical formulations and methods related to stabilizing pharmaceutical formulations using NMP.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: October 4, 2022
    Assignee: Amgen Inc.
    Inventors: Alona Teran, Qahera Munaim, Nazer Khalaf, Rahul Rajan Kaushik, Christi L. Clogston, Twinkle R. Christian, William J. Callahan
  • Crystalline antibody formulations
    Patent number: 11267902
    Abstract: Described herein are anti-PCSK9 antibody crystals, methods of making such antibody crystals and formulations comprising the antibody crystals.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: March 8, 2022
    Inventors: Nazer Khalaf, Saraswathi Mandapati, Reena J. Patel
  • REDUCED VISCOSITY PROTEIN PHARMACEUTICAL FORMULATIONS
    Publication number: 20200024363
    Abstract: Described herein are therapeutic protein formulations comprising N-methyl pyrrolidone (NMP), methods related to reducing viscosity of pharmaceutical formulations and methods related to stabilizing pharmaceutical formulations using NMP.
    Type: Application
    Filed: October 6, 2017
    Publication date: January 23, 2020
    Inventors: Alona Teran, Qahera Muniam, Nazer Khalaf, Rahul Rajan Kaushik, Christi L. Clogston, Twinkle R. Christian, William J. Callahan
  • CRYSTALLINE ANTIBODY FORMULATIONS
    Publication number: 20190127485
    Abstract: Described herein are anti-PCSK9 antibody crystals, methods of making such antibody crystals and formulations comprising the antibody crystals.
    Type: Application
    Filed: November 6, 2018
    Publication date: May 2, 2019
    Applicant: AMGEN INC.
    Inventors: Nazer Khalaf, Saraswathi Mandapati, Reena J. Patel
  • CRYSTALLINE ANTIBODY FORMULATIONS
    Publication number: 20170198059
    Abstract: Described herein are anti-PCSK9 antibody crystals, methods of making such antibody crystals and formulations comprising the antibody crystals.
    Type: Application
    Filed: July 13, 2015
    Publication date: July 13, 2017
    Applicant: AMGEN INC.
    Inventors: Nazer KHALAF, Saraswathi MANDAPATI, Reena J. PATEL
  • Human growth hormone crystals and methods for preparing them
    Patent number: 9376479
    Abstract: The present invention relates to stable, extended release crystals of human growth hormone or a human growth hormone derivative and compositions or formulations comprising such crystals. The invention further provides methods for producing those crystals and compositions. The invention further provides methods for treatment of an individual having disorders associated with human growth hormone deficiency or which are ameliorated by treatment with human growth hormone using those crystals and compositions or formulations.
    Type: Grant
    Filed: December 31, 2003
    Date of Patent: June 28, 2016
    Assignee: Anjinomoto Althea, Inc.
    Inventors: Chandrika Govardhan, Nazer Khalaf, Benjamin Paul Simeone
  • Protein A crystals and cross-linked crystals and methods of use thereof
    Patent number: 9273123
    Abstract: Protein A crystals and Protein A cross-linked protein crystals (CLPCs) are described. Methods of preparing and using are also disclosed.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: March 1, 2016
    Assignee: Ajinomoto Althea, Inc.
    Inventors: Bhami Shenoy, Reena Patel, Sibyl Baladi, Margaret McGrath, Nazer Khalaf, Chanchal Randhawa
  • Protein A Crystals and Cross-Linked Crystals and Methods of Use Thereof
    Publication number: 20150239962
    Abstract: Protein A crystals and Protein A cross-linked protein crystals (CLPCs) are described. Methods of preparing and using are also disclosed.
    Type: Application
    Filed: November 21, 2014
    Publication date: August 27, 2015
    Inventors: Bhami SHENOY, Reena PATEL, Sibyl BALADI, Margaret MCGRATH, Nazer KHALAF, Chanchal RANDHAWA
  • METHODS FOR PREPARING PURIFIED LIPOPEPTIDES
    Publication number: 20150183830
    Abstract: The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention also relates to pharmaceutical compositions comprising the purified form of the lipopeptide and methods of using these compositions.
    Type: Application
    Filed: September 29, 2014
    Publication date: July 2, 2015
    Inventors: Dennis Keith, Jan-Ji Lai, Chandrika Govardhan, Nazer Khalaf
  • Protein a crystals and cross-linked crystals and methods of use thereof
    Patent number: 8921531
    Abstract: Protein A crystals and Protein A cross-linked protein crystals (CLPCs) are described. Methods of preparing and using are also disclosed.
    Type: Grant
    Filed: September 13, 2010
    Date of Patent: December 30, 2014
    Assignee: Althea Technologies, Inc.
    Inventors: Bhami Shenoy, Sibyl Baladi, Reena Patel, Margaret McGrath, Nazer Khalaf, Chanchal Randhawa
  • Methods for preparing purified lipopeptides
    Patent number: 8846610
    Abstract: The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention also relates to pharmaceutical compositions comprising the purified form of the lipopeptide and methods of using these compositions.
    Type: Grant
    Filed: July 31, 2013
    Date of Patent: September 30, 2014
    Assignee: Cubist Pharmaceuticals, Inc.
    Inventors: Dennis Keith, Jan-Ji Lai, Chandrika Govardhan, Nazer Khalaf
  • Methods for preparing purified lipopeptides
    Patent number: 8796224
    Abstract: The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention also relates to pharmaceutical compositions comprising the purified form of the lipopeptide and methods of using these compositions.
    Type: Grant
    Filed: June 27, 2013
    Date of Patent: August 5, 2014
    Assignee: Cubist Pharmaceuticals, Inc.
    Inventors: Dennis Keith, Jan-Ji Lai, Chandrika Govardhan, Nazer Khalaf
  • Methods for preparing purified lipopeptides
    Patent number: 8697638
    Abstract: The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention also relates to pharmaceutical compositions comprising the purified form of the lipopeptide and methods of using these compositions.
    Type: Grant
    Filed: August 26, 2008
    Date of Patent: April 15, 2014
    Assignee: Cubist Pharmaceuticals, Inc.
    Inventors: Dennis Keith, Jan-Ji Lai, Chandrika Govardhan, Nazer Khalaf
  • METHODS FOR PREPARING PURIFIED LIPOPEPTIDES
    Publication number: 20140087425
    Abstract: The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention also relates to pharmaceutical compositions comprising the purified form of the lipopeptide and methods of using these compositions.
    Type: Application
    Filed: July 31, 2013
    Publication date: March 27, 2014
    Applicant: Cubist Pharmaceuticals, Inc.
    Inventors: Dennis Keith, Jan-Ji Lai, Chandrika Govardhan, Nazer Khalaf
  • METHODS FOR PREPARING PURIFIED LIPOPEPTIDES
    Publication number: 20140024577
    Abstract: The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention also relates to pharmaceutical compositions comprising the purified form of the lipopeptide and methods of using these compositions.
    Type: Application
    Filed: June 27, 2013
    Publication date: January 23, 2014
    Inventors: Dennis Keith, Ja-Ji Lai, Chandrika Govardhan, Nazer Khalaf
  • Protein A Crystals and Cross-Linked Crystals and Methods of Use Thereof
    Publication number: 20130053548
    Abstract: Protein A crystals and Protein A cross-linked protein crystals (CLPCs) are described. Methods of preparing and using are also disclosed.
    Type: Application
    Filed: September 13, 2010
    Publication date: February 28, 2013
    Inventors: Bhami Shenoy, Sibyl Baladi, Reena Patel, Margaret McGrath, Nazer Khalaf, Chanchal Randhawa
  • Spherical Protein Particles and Methods of Making and Using Them
    Publication number: 20120282464
    Abstract: This invention relates to SPPs, spherical nanocrystalline composite particles or crystalline SPPs of biologically active proteins or compositions, including formulations, comprising such SPPs, spherical nanocrystalline composite particles or crystalline SPPs. More particularly, methods are provided for the production of SPPs, spherical nanocrystalline composite particles or crystalline SPPs of high concentrations of biologically active proteins, and for the preparation of stabilized SPPs, spherical nanocrystalline composite particles or crystalline SPPs for use alone, or in dry or slurry compositions. This invention also relates to methods for stabilization, storage and delivery of biologically active proteins using SPPs, spherical nanocrystalline composite particles or crystalline SPPs.
    Type: Application
    Filed: July 27, 2011
    Publication date: November 8, 2012
    Applicant: Althea Technologies, Inc.
    Inventors: Kirill YAKOVLEVSKY, Michael Shamashkin, Nazer Khalaf, Chandrika P. Govardhan, Chu W. Jung
  • Spherical protein particles and methods for making and using them
    Patent number: 7998477
    Abstract: This invention relates to SPPs, spherical nanocrystalline composite particles or crystalline SPPs of biologically active proteins or compositions, including formulations, comprising such SPPs, spherical nanocrystalline composite particles or crystalline SPPs. More particularly, methods are provided for the production of SPPs, spherical nanocrystalline composite particles or crystalline SPPs of high concentrations of biologically active proteins, and for the preparation of stabilized SPPs, spherical nanocrystalline composite particles or crystalline SPPs for use alone, or in dry or slurry compositions. This invention also relates to methods for stabilization, storage and delivery of biologically active proteins using SPPs, spherical nanocrystalline composite particles or crystalline SPPs.
    Type: Grant
    Filed: December 19, 2003
    Date of Patent: August 16, 2011
    Assignee: Althea Technologies Inc.
    Inventors: Kirill Yakovlevsky, Michael Shamashkin, Nazer Khalaf, Chandrika P. Govardhan, Chu W. Jung
  • URICASE COMPOSITIONS AND METHODS OF USE
    Publication number: 20110171268
    Abstract: Compositions containing uricase are disclosed. Methods of treating a disorder associated with elevated uric acid concentrations using uricase are also described. Compositions containing uricase and catalase are also disclosed. Methods of treating a disorder associated with elevated uric acid concentrations using uricase and catalase are also described.
    Type: Application
    Filed: March 24, 2009
    Publication date: July 14, 2011
    Applicant: Althea Technologies, Inc.
    Inventors: Bhami Shenoy, Danica Grujic, Reena Patel, Vinney George, Margaret Mcgrath, Nazer Khalaf, Emma Watson
  • METHODS FOR PREPARING PURIFIED LIPOPEPTIDES
    Publication number: 20100041589
    Abstract: The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention also relates to pharmaceutical compositions comprising the purified form of the lipopeptide and methods of using these compositions.
    Type: Application
    Filed: August 26, 2008
    Publication date: February 18, 2010
    Inventors: Dennis Keith, Jan-Ji Lai, Chandrika Govardhan, Nazer Khalaf