Patents by Inventor Nazim El-Andaloussi

Nazim El-Andaloussi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Adenovirus derived helper virus for enhancing recombinant parvovirus production
    Patent number: 9803219
    Abstract: Described is an adenovirus derived helper virus which may comprise the adenoviral DNA sequences for E2a, S4 (orf6), the VA1 RNA gene, and the parvovirus VP capsid gene unit. Also described is a method of efficiently preparing a recombinant parvovirus (particle) which is based on the use of various adenoviral derived helper viruses/vectors.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: October 31, 2017
    Assignee: DEUTSCHES KREBSFORSCHUNGSZENTRUM
    Inventors: Nazim El-Andaloussi, Antonio Marchini, Jean Rommelaere, Barbara Leuchs, Max Endele
  • ADENOVIRUS DERIVED HELPER VIRUS FOR ENHANCING RECOMBINANT PARVOVIRUS PRODUCTION
    Publication number: 20170073704
    Abstract: Described is an adenovirus derived helper virus which may comprise the adenoviral DNA sequences for E2a, S4 (orf6), the VA1 RNA gene, and the parvovirus VP capsid gene unit. Also described is a method of efficiently preparing a recombinant parvovirus (particle) which is based on the use of various adenoviral derived helper viruses/vectors.
    Type: Application
    Filed: September 26, 2012
    Publication date: March 16, 2017
    Applicant: DEUTSCHES KREBSFORSCHUNGSZENTRUM
    Inventors: Nazim EL-ANDALOUSSI, Antonio MARCHINI, Jean ROMMELAERE, Barbara LEUCHS, Max ENDELE
  • Cancer therapy with a parvovirus combined with an HDAC inhibitor
    Patent number: 9592260
    Abstract: Described is a pharmaceutical composition comprising (a) a parvovirus and (b) a histone deacetylase inhibitor (HDACI) and the use of said composition for treatment of cancer, e.g., brain tumor, cervical carcinoma, or pancreatic carcinoma.
    Type: Grant
    Filed: October 6, 2014
    Date of Patent: March 14, 2017
    Assignee: Deutsches Krebsforschungszentrum
    Inventors: Antonio Marchini, Jean Rommelaere, Nazim El-Andaloussi, Georgi Hristov, Junwei Li
  • Adeno-parvovirus chimera with enhanced oncolytical potential
    Patent number: 9441246
    Abstract: Described is a chimerical adenovirus-parvovirus vector characterized in that it comprises the entire parvovirus genome inserted into a adenovirus genome, wherein: (a) the adenovirus genome is characterized by deletion of E1 and E3, and (b) the biological activity of the parvoviral protein NS, preferably NS1, is reduced or eliminated.
    Type: Grant
    Filed: January 6, 2014
    Date of Patent: September 13, 2016
    Assignee: DEUTSCHES KREBSFORSCHUNGSZENTRUM
    Inventors: Nazim El-Andaloussi, Antonio Marchini, Jean Rommelaere
  • Retargeting of rat parvovirus H-1PV to cancer cells through genetic engineering of its capsid
    Patent number: 9234183
    Abstract: Described is a parvovirus, in particular a H-IPV, that can be genetically retargeted through modification of its capsid, which is useful in cancer therapy.
    Type: Grant
    Filed: April 9, 2013
    Date of Patent: January 12, 2016
    Assignee: DEUTSCHES KREBSFORSCHUNGZENTRUM
    Inventors: Antonio Marchini, Nazim El-Andaloussi, Jean Rommelaere, Barbara Leuchs, Xavier Allaume
  • Cancer Therapy with a Parvovirus Combined with an HDAC Inhibitor
    Publication number: 20150030567
    Abstract: Described is a pharmaceutical composition comprising (a) a parvovirus and (b) a histone deacetylase inhibitor (HDACI) and the use of said composition for treatment of cancer, e.g., brain tumor, cervical carcinoma, or pancreatic carcinoma.
    Type: Application
    Filed: October 6, 2014
    Publication date: January 29, 2015
    Inventors: Antonio MARCHINI, Jean ROMMELAERE, Nazim EL-ANDALOUSSI, Georgi HRISTOV, Junwei LI
  • ADENO-PARVOVIRUS CHIMERA WITH ENHANCED ONCOLYTICAL POTENTIAL
    Publication number: 20140235699
    Abstract: Described is a chimerical adenovirus-parvovirus vector characterized in that it comprises the entire parvovirus genome inserted into a adenovirus genome, wherein: (a) the adenovirus genome is characterized by deletion of E1 and E3, and (b) the biological activity of the parvoviral protein NS, preferably NS1, is reduced or eliminated.
    Type: Application
    Filed: January 6, 2014
    Publication date: August 21, 2014
    Applicant: Deutsches Krebsforschungszentrum
    Inventors: Nazim El-Andaloussi, Antonio Marchini, Jean Rommelaere
  • Cancer Therapy with a Parvovirus Combined with an HDAC Inhibitor
    Publication number: 20130058899
    Abstract: Described is a pharmaceutical composition comprising (a) a parvovirus and (b) a histone deacetylase inhibitor (HDACI) and the use of said composition for treatment of cancer, e.g., brain tumor, cervical carcinoma, or pancreatic carcinoma.
    Type: Application
    Filed: March 17, 2011
    Publication date: March 7, 2013
    Applicant: DEUTSCHES KREBSFORSCHUNGSZENTRUM
    Inventors: Antonio Marchini, Jean Rommelaere, Nazim El-Andaloussi, Georgi Hristov, Junwei Li