Abstract: An implantable device includes a portion that is constructed such that at least a majority of the portion, as measured by volume, comprises Ti64 (Ti-6Al-4V) alloy. Additionally, the portion is bendable to a bend angle of at least about 50-degrees about a bend axis while maintaining structural integrity.

Abstract: An insert for a surgical apparatus tray and method of preparing a surgical apparatus tray are described. The insert may include an upper part defining at least one support configured to receive an item of surgical equipment, and defining a first plane and having a plurality of edges defining a polygonal shape. A first side wall may extend downwardly from a first edge of the upper part and define a second plane. The first side wall may have a first, male attachment feature. A second side wall may extend downwardly from a second edge of the upper part and have a second, female attachment feature. The first attachment feature may be configured to mate with the form of the female attachment feature when the first side wall is moved in a direction parallel to the first plane and the second plane to connect the insert to a further insert having a similar construction.

Abstract: An insert for a surgical apparatus tray and method of preparing a surgical apparatus tray are described. The insert may include an upper part defining at least one support configured to receive an item of surgical equipment, and defining a first plane and having a plurality of edges defining a polygonal shape. A first side wall may extend downwardly from a first edge of the upper part and define a second plane. The first side wall may have a first, male attachment feature. A second side wall may extend downwardly from a second edge of the upper part and have a second, female attachment feature. The first attachment feature may be configured to mate with the form of the female attachment feature when the first side wall is moved in a direction parallel to the first plane and the second plane to connect the insert to a further insert having a similar construction.

Abstract: Surgical instrument trays and related methods are described. The surgical instrument tray includes a tray having a plurality of side walls and a base which define an interior space. An insert is located within the interior space of the tray and is removable from the interior space. A lid is provided for closing the interior space and which is removable from the tray. The insert has an upper surface including a plurality of outlines, each outline having the shape of the outline of a corresponding surgical instrument or part of a surgical instrument, each outline being in the form of a continuous strip, and wherein each outline has at least one support arranged to receive and releasably hold the corresponding surgical instrument or part of the surgical instrument above and in registration with the outline.

Abstract: The formation of scars at a wound site is reduced by contacting the wound site with an effective dose of an inhibitor of focal adhesion kinase (FAK) formulated in a pullulan hydrogel The release profile of the FAK inhibitor can be adjusted according to the nature of the wound, e.g., excisional wounds, burn wounds, etc.

Abstract: Embodiment provided herein are directed to microneedle patches for agent application on a mammal skin. The microneedle patch may comprise a patch scaffold having a surface, and a plurality of microneedles disposed on the surface. Each of the microneedles may be capable of piercing the skin 50 ?m to 1000 ?m deep, and comprises a composite material comprising polyvinylpyrrolidone (PVP) and one or more additional copolymers selected from the group consisting of maltose, leucine, and dileucine.

Abstract: Embodiment provided herein are directed to microneedle patches for agent application on a mammal skin. The microneedle patch may comprise a patch scaffold having a surface, and a plurality of microneedles disposed on the surface. Each of the microneedles may be capable of piercing the skin 50 ?m to 1000 ?m deep, and comprises a composite material comprising polyvinylpyrrolidone (PVP) and one or more additional copolymers selected from the group consisting of maltose, leucine, and dileucine.

Abstract: Disclosed herein are methods and drug compositions for treating Lyme disease and post-treatment Lyme disease syndrome (PTLDS) or chronic Lyme disease (CLD). In one embodiment, a method of treating a subject with Lyme disease involves administering an effective amount of a therapeutic agent selected from the group consisting of tetraethylthiuram disulfide, doxorubicin, epirubicin, azlocillin, cephalothin, josamycin, cefotaxime, cefazolin, erythromycin, calcimycin, gramicidin, cefdinir, gambogic acid, ceftazidime, ticarcillin, valinomycin, moxifloxacin, linezolid, idarubicin, tosufloxacin, loratadine, ceftriaxone, and combinations thereof, and pharmaceutical salts, hydrates, and solvates thereof.

Abstract: A smart transmission system is configured to upload data from a plurality of sources to a target application hosted in a cloud environment. A server receives a data stream from the plurality of sources. Using a priority algorithm, the server analyzes the data stream to determine which files and accounts are most critical for the target application's function. The files and their associated accounts are partitioned into tranches, and the tranches are uploaded to the target application in order of priority.

Abstract: Improved electrochemical impedance spectroscopy assays are provided by electrodepositing metallic nanoparticles onto the working electrode for electrochemical impedance spectroscopy. The metallic nanoparticles provide improved assay sensitivity. Electrodeposition of the metallic nanoparticles firmly affixes them to the working electrode, thereby making it easier to clean the working electrode from one assay to the next assay without undesirably removing the metallic nanoparticles.

Abstract: Disclosed herein are methods and drug compositions for treating Lyme disease and post-treatment Lyme disease syndrome (PTLDS) or chronic Lyme disease (CLD). In one embodiment, a method of treating a subject with Lyme disease involves administering an effective amount of a therapeutic agent selected from the group consisting of tetraethylthiuram disulfide, doxorubicin, epirubicin, azlocillin, cephalothin, josamycin, cefotaxime, cefazolin, erythromycin, calcimycin, gramicidin, cefdinir, gambogic acid, ceftazidime, ticarcillin, valinomycin, moxifloxacin, linezolid, idarubicin, tosufloxacin, loratadine, ceftriaxone, and combinations thereof, and pharmaceutical salts, hydrates, and solvates thereof.

Abstract: The present disclosure provides methods and apparatuses for treating tissue ulcers. The apparatuses include elafin protein incorporated into a biocompatible matrix that allows controlled release of the elafin protein to the wound. The biocompatible matrix may be made of biological polymers such as collagen.

Abstract: The present disclosure provides compositions and methods for preventing and treating dyskinesia, such as drug-induced dyskinesia in patients of Parkinson's disease. The compositions, preferably in a sustained release formulation, include L-DOPA, carbidopa, and ranitidine wherein the weight ratio of L-DOPA to carbidopa is in the range of about 1:(0.2-0.3), or include L-DOPA, benserazide, and ranitidine, wherein the weight ratio of L-DOPA to benserazide is in the range of about 1:(0.4-0.6).

Abstract: Embodiment provided herein are directed to microneedle patches for agent application on a mammal skin. The microneedle patch may comprise a patch scaffold having a surface, and a plurality of microneedles disposed on the surface. Each of the microneedles may be capable of piercing the skin 50 ?m to 1000 ?m deep, and comprises a composite material comprising polyvinylpyrrolidone (PVP) and one or more additional copolymers selected from the group consisting of maltose, leucine, and dileucine.

Abstract: Improved electrochemical impedance spectroscopy assays are provided by electrodepositing metallic nanoparticles onto the working electrode for electrochemical impedance spectroscopy. The metallic nanoparticles provide improved assay sensitivity. Electrodeposition of the metallic nanoparticles firmly affixes them to the working electrode, thereby making it easier to clean the working electrode from one assay to the next assay without undesirably removing the metallic nanoparticles.

Abstract: Formulations and methods of use thereof that relate to biocompatible delivery of stabilized porphyrin complexes are provided. Formulations may include microparticles comprising the porphyrin complex, wherein the porphyrin active agent is admixed or coated with a pharmaceutically acceptable stabilizer.

Abstract: Multimedia content may be delivered to content consumer devices via a content-delivery network. Encrypted content and cryptography keys for decrypting the content may be distributed from a data center to various nodes of the content-delivery network, each node acting as a semi-independent content-delivery system. Each content-delivery system is capable of delivering received content to end-users and implementing a key-management scheme to facilitate secure content-delivery and usage tracking, even when the content-delivery system is disconnected from the data center. Further, each content-delivery system may generate an authorization-token that can be transmitted to other systems in the content-delivery network, enabling the other systems to quickly determine that a request to resume a previous content-delivery session has already been authorized.

Abstract: A composite material containing a thermoplastic material and a non-functional aromatic end group-containing polymer is disclosed. Also disclosed are methods of making and use the composite materials.

Abstract: A composite material containing a thermoplastic material and a non-functional aromatic end group-containing polymer is disclosed. Also disclosed are methods of making and use the composite materials.

Abstract: The invention relates to improved polyacetal compositions composed of polyoxymethylene (component A) and a stabilized MBS core shell graft copolymer (component B) formed from a rubber-elastic core based on polybutadiene, and a hard graft shell.The stabilized MBS core shell graft copolymer (component B) contains a special stabilization formulation of at least one hindered phenol, a phosphite, a sulfide, and a pH buffer system.The shaped articles produced from these mixtures are particularly distinguished by an excellent low-temperature impact strength and a good heat aging performance.