Patents by Inventor Neal A. Yakelis

Neal A. Yakelis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLYMERS FOR THERMALLY-REGULATED RELEASE OF HNO AND OTHER MOLECULES
    Publication number: 20170202874
    Abstract: Multivalent scaffolds configured to facilitate drug release upon exposure to a stimulus, such as heat, or light, are described herein. The multivalent scaffolds are covalently bound to a moiety that is susceptible to decomposition upon exposure to stimulus. The moiety releases HNO upon decomposition. In some embodiments, the moiety is in turn linked to an agent to be delivered, such as a therapeutic agent, which is released from the multivalent scaffolds when the moiety decomposes. In some embodiments, the moiety is a 1,2-oxazine moiety. In some embodiments, the multivalent scaffold is a polymer. A plurality of 1,2-oxazine moieties can be covalently bound as side chains to the backbone of the polymer.
    Type: Application
    Filed: January 13, 2017
    Publication date: July 20, 2017
    Applicants: University of Washington, Pacific Lutheran University
    Inventors: Andrew J. Boydston, Neal A. Yakelis, Derek C. Church
  • Thermally-activated self-immolative materials
    Patent number: 9580553
    Abstract: A polymer including a self-immolative polymer segment and a thermally-activated trigger moiety is described. The self-immolative polymer segment includes a head end, a tail end, and a plurality of repeating units. The trigger moiety includes a cycloaddition adduct that is covalently coupled to the head end of the self-immolative polymer segment. When the polymer is exposed to an activation temperature, the cycloaddition adduct undergoes retro-cycloaddition to release the self-immolative polymer segment. The self-immolative polymer segment then decomposes to sequentially release repeating units in a head-to-tail direction.
    Type: Grant
    Filed: December 9, 2013
    Date of Patent: February 28, 2017
    Assignees: University of Washington through its Center for Commercialization, Pacific Lutheran University
    Inventors: Andrew J. Boydston, Neal A. Yakelis, Ronald Jay Berenson, Derek C. Church, Gregory I. Peterson, Michael Larsen
  • THERMALLY-ACTIVATED SELF-IMMOLATIVE MATERIALS
    Publication number: 20150368403
    Abstract: A polymer including a self-immolative polymer segment and a thermally-activated trigger moiety is described. The self-immolative polymer segment includes a head end, a tail end, and a plurality of repeating units. The trigger moiety includes a cycloaddition adduct that is covalently coupled to the head end of the self-immolative polymer segment. When the polymer is exposed to an activation temperature, the cycloaddition adduct undergoes retro-cycloaddition to release the self-immolative polymer segment. The self-immolative polymer segment then decomposes to sequentially release repeating units in a head-to-tail direction.
    Type: Application
    Filed: December 9, 2013
    Publication date: December 24, 2015
    Applicants: University of Washington through its Center for Commercialization, Pacific Lutheran University
    Inventors: Andrew J. Boydston, Neal A. Yakelis, Ronald Jay Berenson, Derek C. Church, Gregory I. Peterson, Michael Larsen