Patents by Inventor Neal C. Smith

Neal C. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treating sickle cell disease with a pyruvate kinase R activating compound
    Patent number: 11980611
    Abstract: Compounds that activate pyruvate kinase R can be used for the treatment of sickle cell disease (SCD). Methods and compositions for the treatment of SCD are provided herein, including a therapeutic compound designated as Compound 1.
    Type: Grant
    Filed: December 22, 2022
    Date of Patent: May 14, 2024
    Assignee: Novo Nordisk Health Care AG
    Inventors: Anna Ericsson, Neal Green, Gary Gustafson, Bingsong Han, David R. Lancia, Jr., Lorna Mitchell, David Richard, Tatiana Shelekhin, Chase C. Smith, Zhongguo Wang, Xiaozhang Zheng
  • PYRROLOPYRROLE COMPOSITIONS AS PYRUVATE KINASE (PKR) ACTIVATORS
    Publication number: 20240083901
    Abstract: The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.
    Type: Application
    Filed: March 21, 2023
    Publication date: March 14, 2024
    Inventors: Anna ERICSSON, Neal GREEN, Gary GUSTAFSON, Bingsong HAN, David R. LANCIA, JR., Lorna MITCHELL, David RICHARD, Tatiana SHELEKHIN, Chase C. SMITH, Zhongguo WANG, Xiaozhang ZHENG
  • SUTURES AND METHODS OF MAKING THE SAME
    Publication number: 20090105753
    Abstract: A non-braided suture and methods of making and using the same are disclosed. The suture can be woven, for example, from warp yarns and a fill yarn. The suture can have a sheath. The sheath can have a lubricious coating on the inside and the outside of the sheath. The suture can have a textured surface. The suture can furcate. Methods of using the suture are also disclosed.
    Type: Application
    Filed: August 26, 2005
    Publication date: April 23, 2009
    Applicant: Prodesco, Inc.
    Inventors: E. Skott Greenhalgh, Neal C. Smith