Abstract: A method of manufacturing a premeasured compressed charge in which the compressed charge has a leading end portion with a smaller dimension than both a trailing end portion and a desired caliber of the intended firearm and the trailing end portion has a larger diagonal dimension than the desired caliber of the firearm. The method comprises the steps of providing a mold with cavities, filling the mold cavities with gunpowder, pressing gunpowder to form a compressed charge so that one of a density and a compaction of the gunpowder, adjacent the leading end portion of the compressed charge, is about 0% to about 5% less than the density or the compaction of the gunpowder adjacent the trailing end portion to facilitate a more complete combustion of the compressed charge upon discharge of the firearm, and removing the compressed charge from the cavities.

Abstract: A method of manufacturing a premeasured compressed charge in which the compressed charge has a leading end portion with a smaller dimension than both a trailing end portion and a desired caliber of the intended firearm and the trailing end portion has a larger diagonal dimension than the desired caliber of the firearm. The method comprises the steps of providing a mold with cavities, filling the mold cavities with gunpowder, pressing gunpowder to form a compressed charge so that one of a density and a compaction of the gunpowder, adjacent the leading end portion of the compressed charge, is about 0% to about 5% less than the density or the compaction of the gunpowder adjacent the trailing end portion to facilitate a more complete combustion of the compressed charge upon discharge of the firearm, and removing the compressed charge from the cavities.

Abstract: A clean burning premeasured compressed charge for use in black powder firearms as well as cartridges. The premeasured compressed charge is manufactured to have a substantially desired shape which facilitates improved flame propagation by the leading end wall and along the exposed sidewall surfaces of the compressed charge to result in a more complete and rapid burning of the compressed charge both from the leading end wall toward the trailing end wall and also radially inwardly from each one of the four sidewalls toward a center of the premeasured compressed charge. The premeasured compressed charge has a leading end portion and a trailing end portion and the leading end portion is either the same size or a smaller dimension than the trailing end portion.

Abstract: A clean burning premeasured compressed charge for use in black powder firearms as well as cartridges. The premeasured compressed charge is manufactured to have a substantially desired shape which facilitates improved flame propagation by the leading end wall and along the exposed sidewall surfaces of the compressed charge to result in a more complete and rapid burning of the compressed charge both from the leading end wall toward the trailing end wall and also radially inwardly from each one of the four sidewalls toward a center of the premeasured compressed charge. The premeasured compressed charge has a leading end portion and a trailing end portion and the leading end portion is either the same size or a smaller dimension than the trailing end portion.

Abstract: Antibodies are disclosed herein that bind Spoc cells. In one embodiment the antibodies are monoclonal antibodies. The use of antibodies that bind Spoc cells to identify and/or isolate a sub-population of Spoc cells is also disclosed. In one embodiment, a method for treating a neurologic disorder is provided. The method includes administering a sub-population of Spoc cells and/or and neuronal cells differentiated from Spoc cells to treat a neurologic disorder.

Abstract: Disclosed herein is a novel isolated population of stem cells, called spoc cells, that can be induced, either in vivo or in vitro, to differentiate into cardiomyocytes. Methods are disclosed herein to differentiate the spoc cells, and to utilize these spoc cells for screening agents that affect cardiomyocytes. Methods are also provided herein to utilize spoc cells in therapeutic applications for the treatment of myocardial defects, such as areas of ischemic or traumatic damage.

Abstract: A transport container with a removable cover which is repeatedly removable and refastenable to the transport container. The transport container is sized to accommodate a plurality of individual premeasured charges of gunpowder. Each of the plurality of individual premeasured charges of gunpowder comprises a tube which is open at least one end thereof and the at least one open end of the tube is sealed with a removable cap once a suitable quantity of the loose granular charge of gunpowder is loaded therein. Each individual premeasured charge of gunpowder is loaded with gunpowder which has a relatively low moisture content to facilitate reliable and substantially complete ignition of all of the gunpowder ignition, upon detonation of a firearm.

Abstract: Disclosed herein is a novel isolated population of stem cells, called spoc cells, that can be induced, either in vivo or in vitro, to differentiate into cardiomyocytes. Methods are disclosed herein to differentiate the spoc cells, and to utilize these spoc cells for screening agents that affect cardiomyocytes. Methods are also provided herein to utilize spoc cells in therapeutic applications for the treatment of myocardial defects, such as areas of ischemic or traumatic damage.

Abstract: A transport container with a removable cover which is repeatedly removable and refastenable to the transport container. The transport container is sized to accommodate a plurality of individual premeasured charges of gunpowder. Each of the plurality of individual premeasured charges of gunpowder comprises a tube which is open at least one end thereof and the at least one open end of the tube is sealed with a removable cap once a suitable quantity of the loose granular charge of gunpowder is loaded therein. Each individual premeasured charge of gunpowder is loaded with gunpowder which has a relatively low moisture content to facilitate reliable and substantially complete ignition of all of the gunpowder ignition, upon detonation of a firearm.

Abstract: A clean burning premeasured compressed charge for use in black powder firearms as well as cartridges. The premeasured compressed charge is manufactured to have a substantially desired shape which facilitates improved flame propagation by the leading end wall and along the exposed sidewall surfaces of the compressed charge to result in a more complete and rapid burning of the compressed charge both from the leading end wall toward the trailing end wall and also radially inwardly from each one of the four sidewalls toward a center of the premeasured compressed charge. The premeasured compressed charge has a leading end portion and a trailing end portion and the leading end portion is either the same size or a smaller dimension than the trailing end portion.

Abstract: A clean burning premeasured compressed charge for use in black powder firearms as well as cartridges. The premeasured compressed charge is manufactured to have a substantially desired shape which facilitates improved flame propagation by the leading end wall and along the exposed sidewall surfaces of the compressed charge to result in a more complete and rapid burning of the compressed charge both from the leading end wall toward the trailing end wall and also radially inwardly from each one of the four sidewalls toward a center of the premeasured compressed charge. The premeasured compressed charge has a leading end portion and a trailing end portion and the leading end portion is either the same size or a smaller dimension than the trailing end portion.