Patents by Inventor Neal G. Anderson

Neal G. Anderson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enzymatic oxidative deamination process
    Patent number: 6515170
    Abstract: The present invention concerns an enzymatic oxidative deamination process of a dipeptide monomer to prepare an intermediate useful to prepare compounds having endopeptidase and angiotensin converting enzyme inhibition activity.
    Type: Grant
    Filed: April 26, 2001
    Date of Patent: February 4, 2003
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Ramesh N. Patel, Amit Banerjee, Venkata B. Nanduri, Steven L. Goldberg, Robert M. Johnston, Thomas P. Tully, Laszlo J. Szarka, Shankar Swaminathan, John J. Venit, Jerome L. Moniot, William J. Winter, Neal G. Anderson, David A. Lust, Gerard Crispino, Sushil K. Srivastava
  • Method for preparing N-substituted heterocyclic derivatives using a phase-transfer catalyst
    Patent number: 6162922
    Abstract: Disclosed is a process for preparing N-substituted heterocyclic derivatives and its salts using phase transfer catalysis.
    Type: Grant
    Filed: January 19, 1999
    Date of Patent: December 19, 2000
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Neal G. Anderson, Rajendra P. Deshpande, Jerome L. Moniot
  • Process for direct isolation of captopril
    Patent number: 5026873
    Abstract: A process is disclosed for direct isolation of captopril from a substrate of the formula ##STR1## wherein R is lower alkyl or lower alkoxy. In this process, the substrate is first treated with an aqueous alkali metal hydroxide capable of forming a water-soluble salt of the substrate, wherein the alkali metal hydroxide has a concentration of 4M or greater. The substrate is then neutralized, preferably with a mineral acid. By this process, captopril may be directly crystallized from an aqueous solution, avoiding the prior art use of organic solvents and zinc treatment to reduce levels of sulfide and disulfide impurities, respectively. In an alternative embodiment, neutralization is carried out by use of a hydrogen-supplying ion exchange resin.
    Type: Grant
    Filed: November 6, 1989
    Date of Patent: June 25, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Neal G. Anderson, David A. Lust, Barbara J. Bennett, Alan F. Feldman, Robert E. Polomski
  • Process for stereochemically inverting a hydroxy function of an ester by a modified Mitsunobu reaction process
    Patent number: 4912230
    Abstract: A process is provided for inverting a hydroxy function of a L-trans-hydroxy proline derivative to the corresponding L-cis-hydroxy proline sulfonate by a Modified Mitsunobu reaction process.
    Type: Grant
    Filed: September 16, 1988
    Date of Patent: March 27, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Neal G. Anderson, Christopher M. Cimarusti, David A. Lust
  • Delta form of aztreonam and preparation thereof
    Patent number: 4826973
    Abstract: The crystalline delta(.delta.)-form of [3S-[3.alpha.(Z),-4.beta.]]-3-[[(2-amino-4-thiazolyl) [(1-carboxy-1-methylethoxy)imino]acetyl]amino]-4-methyl-2-oxo-1-azetidines ulfonic acid is prepared.
    Type: Grant
    Filed: December 10, 1985
    Date of Patent: May 2, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Neal G. Anderson, Carl F. Anderson
  • Process for preparing pyrrole-2-acetic acids
    Patent number: 4284562
    Abstract: N-H and N-loweralkyl pyrrole-2-acetic acids are prepared by the reduction of 1-H and 1-loweralkyl-.alpha.-trichloromethylpyrrole-2-methanol with sodium dithionite (sodium hydrosulfite) in the presence of a base, MOH, wherein M is an alkali metal, an alkaline earth metal or tetraalkyl ammonium.
    Type: Grant
    Filed: June 20, 1980
    Date of Patent: August 18, 1981
    Assignee: McNeilab, Inc.
    Inventors: Neal G. Anderson, John R. Carson