Patents by Inventor Neal K. Vail
Neal K. Vail has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210386672Abstract: Oral preparations of microcapsules and nanoparticles including an inhibitor of the mammalian target of rapamycin. The preparations are intended to assist with the treatment and prevention of cancer, neurocognitive dysfunction, genetically predisposed disorders, and age-related disorders. The embodiments discussed address the present need for alternative preparations or manufacturing processes that ensure efficacy while improving other performance characteristics such as storage stability, biodistribution, dosage cost, etc.Type: ApplicationFiled: August 2, 2021Publication date: December 16, 2021Applicant: Rapamycin Holdings, Inc.Inventors: Dana Vaughn, Neal K. Vail
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Patent number: 11077061Abstract: Oral preparations of microcapsules and nanoparticles including an inhibitor of the mammalian target of rapamycin. The preparations are intended to assist with the treatment and prevention of cancer, neurocognitive dysfunction, genetically predisposed disorders, and age-related disorders. The embodiments discussed address the present need for alternative preparations or manufacturing processes that ensure efficacy while improving other performance characteristics such as storage stability, biodistribution, dosage cost, etc.Type: GrantFiled: July 31, 2019Date of Patent: August 3, 2021Assignee: Rapamycin Holdings, Inc.Inventors: Dana Vaughn, Neal K. Vail
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Publication number: 20190350856Abstract: Oral preparations of microcapsules and nanoparticles including an inhibitor of the mammalian target of rapamycin. The preparations are intended to assist with the treatment and prevention of cancer, neurocognitive dysfunction, genetically predisposed disorders, and age-related disorders. The embodiments discussed address the present need for alternative preparations or manufacturing processes that ensure efficacy while improving other performance characteristics such as storage stability, biodistribution, dosage cost, etc.Type: ApplicationFiled: July 31, 2019Publication date: November 21, 2019Applicant: Rapamycin Holdings, Inc.Inventors: Dana Vaughn, Neal K. Vail
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Patent number: 10391059Abstract: Oral preparations of microcapsules and nanoparticles including an inhibitor of the mammalian target of rapamycin. The preparations are intended to assist with the treatment and prevention of cancer, neurocognitive dysfunction, genetically predisposed disorders, and age-related disorders. The embodiments discussed address the present need for alternative preparations or manufacturing processes that ensure efficacy while improving other performance characteristics such as storage stability, biodistribution, dosage cost, etc.Type: GrantFiled: December 31, 2014Date of Patent: August 27, 2019Assignee: Rapamycin Holdings, Inc.Inventors: Neal K Vail, Dana M Vaughn
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Patent number: 9700544Abstract: Oral preparations of microcapsules and nanoparticles including an inhibitor of the mammalian target of rapamycin. The preparations are intended to assist with the treatment and prevention of cancer neurocognitive dysfunction, genetically predisposed disorders, and age-related disorders. The embodiments discussed address the present need for alternative preparations or manufacturing processes that ensure efficacy while improving other performance characteristics such as storage stability, biodistribution, dosage cost, etc.Type: GrantFiled: March 20, 2014Date of Patent: July 11, 2017Inventors: Neal K Vail, Dana M Vaughn
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Patent number: 9693967Abstract: This invention is directed to an apparatus and method for producing microparticles comprising pharmacologically active agents and biodegradable polymers. The apparatus includes a spinning disk containing a reservoir in the center thereof and a flat inclined surface. The apparatus optionally includes serrations and/or a flat surface beneath the periphery of the disk that is parallel to the rotational axis of the disk. The invention is also directed to a method for producing microparticles containing pharmacologically active agents, using the spinning disk apparatus. Formulations containing ophthalmically active agents are provided. Formulations exhibiting zero order release rates are also described.Type: GrantFiled: September 7, 2005Date of Patent: July 4, 2017Assignee: SOUTHWEST RESEARCH INSTITUTEInventors: Joseph T. Persyn, Joseph A. McDonough, Neal K. Vail, Darren E. Barlow, Albert M. Zwiener, Eliot M. Slovin
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Publication number: 20160324782Abstract: Oral preparations of microcapsules and nanoparticles including an inhibitor of the mammalian target of rapamycin. The preparations are intended to assist with the treatment and prevention of cancer, neurocognitive dysfunction, genetically predisposed disorders, and age-related disorders. The embodiments discussed address the present need for alternative preparations or manufacturing processes that ensure efficacy while improving other performance characteristics such as storage stability, biodistribution, dosage cost, etc.Type: ApplicationFiled: December 31, 2014Publication date: November 10, 2016Applicant: Rapamycin Holdings, Inc.Inventors: Neal K Vail, Dana M Vaughn
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Publication number: 20150202164Abstract: Oral preparations of microcapsules and nanoparticles including an inhibitor of the mammalian target of rapamycin. The preparations are intended to assist with the treatment and prevention of cancer neurocognitive dysfunction, genetically predisposed disorders, and age-related disorders. The embodiments discussed address the present need for alternative preparations or manufacturing processes that ensure efficacy while improving other performance characteristics such as storage stability, biodistribution, dosage cost, etc.Type: ApplicationFiled: March 20, 2014Publication date: July 23, 2015Inventors: Neal K. Vail, Dana M. Vaughn
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Patent number: 7758778Abstract: This invention is directed to an apparatus and method for producing microparticles comprising pharmacologically active agents and biodegradable polymers. The apparatus includes a spinning disk containing a reservoir in the center thereof and a flat inclined surface. The apparatus optionally includes serrations and/or a flat surface beneath the periphery of the disk that is parallel to the rotational axis of the disk. The invention is also directed to a method for producing microparticles containing pharmacologically active agents, using the spinning disk apparatus. Formulations containing ophthalmically active agents are provided. Formulations exhibiting zero order release rates are also described.Type: GrantFiled: September 7, 2005Date of Patent: July 20, 2010Assignee: Southwest Research InstituteInventors: Joseph T. Persyn, Joseph A. McDonough, Neal K. Vail, Darren E. Barlow, Albert M. Zwiener, Eliot M. Slovin
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Patent number: 7422607Abstract: The present invention provides processes for fixation of biological tissue and/or post-fixation treatment of such tissue that result in modified tissues with reduced susceptibility to in vitro calcification when used in prosthetic devices. The invention also relates to calcification resistant biological tissue and to methods of using such tissue.Type: GrantFiled: August 23, 2005Date of Patent: September 9, 2008Inventors: Henry W. Oviatt, Neal K. Vail
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Patent number: 7381426Abstract: The invention provides methods and compositions for the delivery of bioactive factors to the systemic skeleton. The methods of the invention allow targeted delivery of bioactive factors to bone using nanocapsules. Timed release of bioactive factors may also be used to increase the efficacy of treatment. The methods of the invention have wide applicability for the treatment or prevention of bone-associated maladies.Type: GrantFiled: January 24, 2003Date of Patent: June 3, 2008Assignee: Southwest Research InstituteInventor: Neal K. Vail
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Patent number: 7261529Abstract: This invention is directed to an apparatus and method for producing microparticles comprising pharmacologically active agents and biodegradable polymers. The apparatus includes a spinning disk containing a reservoir in the center thereof and a flat inclined surface. The apparatus optionally includes serrations and/or a flat surface beneath the periphery of the disk that is parallel to the rotational axis of the disk. The invention is also directed to a method for producing microparticles containing pharmacologically active agents, using the spinning disk apparatus. Formulations containing ophthalmically active agents are provided. Formulations exhibiting zero order release rates are also described.Type: GrantFiled: September 7, 2005Date of Patent: August 28, 2007Assignee: Southwest Research InstituteInventors: Joseph T. Persyn, Joseph A. McDonough, Neal K. Vail, Darren E. Barlow, Albert M. Zwiener, Eliot M. Slovin
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Publication number: 20030203038Abstract: The invention provides methods and compositions for the delivery of bioactive factors to the systemic skeleton. The methods of the invention allow targeted delivery of bioactive factors to bone using nanocapsules. Timed release of bioactive factors may also be used to increase the efficacy of treatment. The methods of the invention have wide applicability for the treatment or prevention of bone-associated maladies.Type: ApplicationFiled: January 24, 2003Publication date: October 30, 2003Applicant: Southwest Research InstituteInventor: Neal K. Vail
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Patent number: 6048954Abstract: The development of polymer binder compositions that provide novel binders for high temperature inorganic particulates, especially metal and ceramic particulates is described. These materials are especially useful in a laser beam sintering process known as SLS.TM. that forms accurately shaped high strength green objects. The new binders may be thermally removed in post-shaping operations without significant residual ash. The resulting structures contain only metal, ceramic, or metal ceramic materials. The inventive methods developed for producing the new polymeric binder materials are based in part on using emulsion forms of selected polymers at controlled low molecular weights and high melt flow. An important aspect of the process is the semi-batch addition of selected chain transfer agents to the reacting emulsion. This optimizes coating characteristics of the polymer binder and results in high part strengths of the prototype parts produced in the SLS.TM. process.Type: GrantFiled: June 24, 1997Date of Patent: April 11, 2000Assignee: The University of Texas System Board of RegentsInventors: Joel W. Barlow, Neal K. Vail
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Patent number: 5678162Abstract: A mold useful for injection molding, comprising: a porous network of metal and oxidized metal and a cured epoxy resin dispersed in the porous network. The mold can be prepared by a process comprising the sequential steps of (a) forming a mixture of a metal powder and a polymer binder; (b) heating the mixture at a temperature in the range from about 100.degree. C. to about 300.degree. C. to remove a majority of the polymer binder from the mixture; (c) heating the mixture resulting from step (b) at a temperature greater than about 300.degree. C. and less than the melting point of the metal in the presence of oxygen to oxidize at least a portion of the metal to form a self-adhering porous network of metal and oxidized metal; (d) contacting the self-adhering porous network with an epoxy resin to fill at least a portion of the porous network with epoxy resin; and (e) curing the body resulting from step (d) to form the mold. The shape of the mold can be performed by selective laser sintering of the mixture.Type: GrantFiled: November 14, 1994Date of Patent: October 14, 1997Assignee: Board of Regents, Univ. of Texas SystemInventors: Joel W. Barlow, Balasubramanian Badrinarayan, Joseph J. Beaman, David L. Bourell, Richard H. Crawford, Harris L. Marcus, James R. Tobin, Neal K. Vail
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Patent number: 5284695Abstract: A method of producing high temperature parts by way of relatively low temperature sintering is disclosed. A powder is produced, for example by spray drying a slurry, in which particles of a high temperature material such as a ceramic are partially coated with a low temperature material such as a polymer. The powder is subjected to selective laser sintering, or another heat-based layerwise additive process, to form a green part where the ceramic particles are bound by the polymer. The green part is permeated with a cementing agent having high temperature properties when cured; the cementing agent binds the exposed ceramic surfaces in the green part. The polymer is then removed, leaving the high temperature part. Additional cementing agent, or another high temperature material, may then be added to the part after removal of the polymer.Type: GrantFiled: March 20, 1992Date of Patent: February 8, 1994Assignee: Board of Regents, The University of Texas SystemInventors: Joel W. Barlow, Neal K. Vail