Patents by Inventor Neal K. Vail

Neal K. Vail has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10391059
    Abstract: Oral preparations of microcapsules and nanoparticles including an inhibitor of the mammalian target of rapamycin. The preparations are intended to assist with the treatment and prevention of cancer, neurocognitive dysfunction, genetically predisposed disorders, and age-related disorders. The embodiments discussed address the present need for alternative preparations or manufacturing processes that ensure efficacy while improving other performance characteristics such as storage stability, biodistribution, dosage cost, etc.
    Type: Grant
    Filed: December 31, 2014
    Date of Patent: August 27, 2019
    Assignee: Rapamycin Holdings, Inc.
    Inventors: Neal K Vail, Dana M Vaughn
  • Patent number: 9700544
    Abstract: Oral preparations of microcapsules and nanoparticles including an inhibitor of the mammalian target of rapamycin. The preparations are intended to assist with the treatment and prevention of cancer neurocognitive dysfunction, genetically predisposed disorders, and age-related disorders. The embodiments discussed address the present need for alternative preparations or manufacturing processes that ensure efficacy while improving other performance characteristics such as storage stability, biodistribution, dosage cost, etc.
    Type: Grant
    Filed: March 20, 2014
    Date of Patent: July 11, 2017
    Inventors: Neal K Vail, Dana M Vaughn
  • Patent number: 9693967
    Abstract: This invention is directed to an apparatus and method for producing microparticles comprising pharmacologically active agents and biodegradable polymers. The apparatus includes a spinning disk containing a reservoir in the center thereof and a flat inclined surface. The apparatus optionally includes serrations and/or a flat surface beneath the periphery of the disk that is parallel to the rotational axis of the disk. The invention is also directed to a method for producing microparticles containing pharmacologically active agents, using the spinning disk apparatus. Formulations containing ophthalmically active agents are provided. Formulations exhibiting zero order release rates are also described.
    Type: Grant
    Filed: September 7, 2005
    Date of Patent: July 4, 2017
    Assignee: SOUTHWEST RESEARCH INSTITUTE
    Inventors: Joseph T. Persyn, Joseph A. McDonough, Neal K. Vail, Darren E. Barlow, Albert M. Zwiener, Eliot M. Slovin
  • Publication number: 20160324782
    Abstract: Oral preparations of microcapsules and nanoparticles including an inhibitor of the mammalian target of rapamycin. The preparations are intended to assist with the treatment and prevention of cancer, neurocognitive dysfunction, genetically predisposed disorders, and age-related disorders. The embodiments discussed address the present need for alternative preparations or manufacturing processes that ensure efficacy while improving other performance characteristics such as storage stability, biodistribution, dosage cost, etc.
    Type: Application
    Filed: December 31, 2014
    Publication date: November 10, 2016
    Applicant: Rapamycin Holdings, Inc.
    Inventors: Neal K Vail, Dana M Vaughn
  • Publication number: 20150202164
    Abstract: Oral preparations of microcapsules and nanoparticles including an inhibitor of the mammalian target of rapamycin. The preparations are intended to assist with the treatment and prevention of cancer neurocognitive dysfunction, genetically predisposed disorders, and age-related disorders. The embodiments discussed address the present need for alternative preparations or manufacturing processes that ensure efficacy while improving other performance characteristics such as storage stability, biodistribution, dosage cost, etc.
    Type: Application
    Filed: March 20, 2014
    Publication date: July 23, 2015
    Inventors: Neal K. Vail, Dana M. Vaughn
  • Patent number: 7758778
    Abstract: This invention is directed to an apparatus and method for producing microparticles comprising pharmacologically active agents and biodegradable polymers. The apparatus includes a spinning disk containing a reservoir in the center thereof and a flat inclined surface. The apparatus optionally includes serrations and/or a flat surface beneath the periphery of the disk that is parallel to the rotational axis of the disk. The invention is also directed to a method for producing microparticles containing pharmacologically active agents, using the spinning disk apparatus. Formulations containing ophthalmically active agents are provided. Formulations exhibiting zero order release rates are also described.
    Type: Grant
    Filed: September 7, 2005
    Date of Patent: July 20, 2010
    Assignee: Southwest Research Institute
    Inventors: Joseph T. Persyn, Joseph A. McDonough, Neal K. Vail, Darren E. Barlow, Albert M. Zwiener, Eliot M. Slovin
  • Patent number: 7422607
    Abstract: The present invention provides processes for fixation of biological tissue and/or post-fixation treatment of such tissue that result in modified tissues with reduced susceptibility to in vitro calcification when used in prosthetic devices. The invention also relates to calcification resistant biological tissue and to methods of using such tissue.
    Type: Grant
    Filed: August 23, 2005
    Date of Patent: September 9, 2008
    Inventors: Henry W. Oviatt, Neal K. Vail
  • Patent number: 7381426
    Abstract: The invention provides methods and compositions for the delivery of bioactive factors to the systemic skeleton. The methods of the invention allow targeted delivery of bioactive factors to bone using nanocapsules. Timed release of bioactive factors may also be used to increase the efficacy of treatment. The methods of the invention have wide applicability for the treatment or prevention of bone-associated maladies.
    Type: Grant
    Filed: January 24, 2003
    Date of Patent: June 3, 2008
    Assignee: Southwest Research Institute
    Inventor: Neal K. Vail
  • Patent number: 7261529
    Abstract: This invention is directed to an apparatus and method for producing microparticles comprising pharmacologically active agents and biodegradable polymers. The apparatus includes a spinning disk containing a reservoir in the center thereof and a flat inclined surface. The apparatus optionally includes serrations and/or a flat surface beneath the periphery of the disk that is parallel to the rotational axis of the disk. The invention is also directed to a method for producing microparticles containing pharmacologically active agents, using the spinning disk apparatus. Formulations containing ophthalmically active agents are provided. Formulations exhibiting zero order release rates are also described.
    Type: Grant
    Filed: September 7, 2005
    Date of Patent: August 28, 2007
    Assignee: Southwest Research Institute
    Inventors: Joseph T. Persyn, Joseph A. McDonough, Neal K. Vail, Darren E. Barlow, Albert M. Zwiener, Eliot M. Slovin
  • Publication number: 20030203038
    Abstract: The invention provides methods and compositions for the delivery of bioactive factors to the systemic skeleton. The methods of the invention allow targeted delivery of bioactive factors to bone using nanocapsules. Timed release of bioactive factors may also be used to increase the efficacy of treatment. The methods of the invention have wide applicability for the treatment or prevention of bone-associated maladies.
    Type: Application
    Filed: January 24, 2003
    Publication date: October 30, 2003
    Applicant: Southwest Research Institute
    Inventor: Neal K. Vail
  • Patent number: 6048954
    Abstract: The development of polymer binder compositions that provide novel binders for high temperature inorganic particulates, especially metal and ceramic particulates is described. These materials are especially useful in a laser beam sintering process known as SLS.TM. that forms accurately shaped high strength green objects. The new binders may be thermally removed in post-shaping operations without significant residual ash. The resulting structures contain only metal, ceramic, or metal ceramic materials. The inventive methods developed for producing the new polymeric binder materials are based in part on using emulsion forms of selected polymers at controlled low molecular weights and high melt flow. An important aspect of the process is the semi-batch addition of selected chain transfer agents to the reacting emulsion. This optimizes coating characteristics of the polymer binder and results in high part strengths of the prototype parts produced in the SLS.TM. process.
    Type: Grant
    Filed: June 24, 1997
    Date of Patent: April 11, 2000
    Assignee: The University of Texas System Board of Regents
    Inventors: Joel W. Barlow, Neal K. Vail
  • Patent number: 5678162
    Abstract: A mold useful for injection molding, comprising: a porous network of metal and oxidized metal and a cured epoxy resin dispersed in the porous network. The mold can be prepared by a process comprising the sequential steps of (a) forming a mixture of a metal powder and a polymer binder; (b) heating the mixture at a temperature in the range from about 100.degree. C. to about 300.degree. C. to remove a majority of the polymer binder from the mixture; (c) heating the mixture resulting from step (b) at a temperature greater than about 300.degree. C. and less than the melting point of the metal in the presence of oxygen to oxidize at least a portion of the metal to form a self-adhering porous network of metal and oxidized metal; (d) contacting the self-adhering porous network with an epoxy resin to fill at least a portion of the porous network with epoxy resin; and (e) curing the body resulting from step (d) to form the mold. The shape of the mold can be performed by selective laser sintering of the mixture.
    Type: Grant
    Filed: November 14, 1994
    Date of Patent: October 14, 1997
    Assignee: Board of Regents, Univ. of Texas System
    Inventors: Joel W. Barlow, Balasubramanian Badrinarayan, Joseph J. Beaman, David L. Bourell, Richard H. Crawford, Harris L. Marcus, James R. Tobin, Neal K. Vail
  • Patent number: 5284695
    Abstract: A method of producing high temperature parts by way of relatively low temperature sintering is disclosed. A powder is produced, for example by spray drying a slurry, in which particles of a high temperature material such as a ceramic are partially coated with a low temperature material such as a polymer. The powder is subjected to selective laser sintering, or another heat-based layerwise additive process, to form a green part where the ceramic particles are bound by the polymer. The green part is permeated with a cementing agent having high temperature properties when cured; the cementing agent binds the exposed ceramic surfaces in the green part. The polymer is then removed, leaving the high temperature part. Additional cementing agent, or another high temperature material, may then be added to the part after removal of the polymer.
    Type: Grant
    Filed: March 20, 1992
    Date of Patent: February 8, 1994
    Assignee: Board of Regents, The University of Texas System
    Inventors: Joel W. Barlow, Neal K. Vail